hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10530.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
GYPB	Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b)	5	UniProt NCBI
BZW1	eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf)	5	UniProt NCBI
EIF2B2	Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)	5	UniProt NCBI
EIF2B1	Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha)	5	UniProt NCBI
EIF2B3	Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma)	5	UniProt NCBI
ASIC2	Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)	5	UniProt NCBI
SEC62	Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1)	4	UniProt NCBI
EIF2B4	Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)	5	UniProt NCBI
EXOG	Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)	5	UniProt NCBI
BZW2	eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2)	5	UniProt NCBI
PTAFR	Platelet-activating factor receptor (PAF-R) (PAFr)	5	UniProt NCBI
IPO9	Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)	5	UniProt NCBI
MAVS	Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)	5	UniProt NCBI
CIP2A	Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)	5	UniProt NCBI
SPN	Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]	5	UniProt NCBI
EIF2B5	Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7292	1.88171091104e-14	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
REAC:R-HSA-72731	5.66261981635e-12	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	Recycling of eIF2:GDP
GO:0005851	1.80267905278e-11	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	eukaryotic translation initiation factor 2B complex
CORUM:7291	2.74936781213e-11	0.285714285714	EIF2B2 EIF2B5 EIF2B4 EIF2B3	EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
WP:WP107	7.83364820161e-08	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	Translation factors
GO:0014003	1.10864386311e-07	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	oligodendrocyte development
GO:0006413	1.32822024229e-07	0.5	EIF2B3 BZW2 EIF2B1 EIF2B4 BZW1 EIF2B5 EIF2B2	translational initiation
GO:0048709	5.76255972408e-06	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	oligodendrocyte differentiation
REAC:R-HSA-72613	1.67180050838e-05	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	Eukaryotic Translation Initiation
REAC:R-HSA-72737	1.67180050838e-05	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	Cap-dependent Translation Initiation
GO:0003743	1.91887693921e-05	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	translation initiation factor activity
KEGG:05168	3.39077765277e-05	0.428571428571	EIF2B3 MAVS EIF2B1 EIF2B4 EIF2B5 EIF2B2	Herpes simplex virus 1 infection
GO:0021782	3.7321184062e-05	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	glial cell development
GO:0009408	9.57087558217e-05	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	response to heat
HP:0000869	0.000200046212997	0.285714285714	EIF2B3 EIF2B2 EIF2B4 EIF2B1	Secondary amenorrhea
GO:0008135	0.000211006804934	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	translation factor activity, RNA binding
GO:0009749	0.00026146379979	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	response to glucose
GO:0009746	0.000300130459659	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	response to hexose
GO:0034284	0.000300130459659	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	response to monosaccharide
GO:0009266	0.000416966191551	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	response to temperature stimulus
GO:0009743	0.000472767824479	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	response to carbohydrate
GO:0090079	0.000567467813716	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	translation regulator activity, nucleic acid binding
WP:WP5316	0.000631115667297	0.285714285714	EIF2B2 EIF2B5 EIF2B4 EIF2B3	Primary ovarian insufficiency
GO:0010001	0.000802045531847	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	glial cell differentiation
GO:0050852	0.000895406357537	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	T cell receptor signaling pathway
REAC:R-HSA-72766	0.00139514442693	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	Translation
GO:0045182	0.00209026342982	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	translation regulator activity
GO:0050851	0.00297580490491	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	antigen receptor-mediated signaling pathway
GO:0042063	0.00337586436257	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	gliogenesis
HP:0000141	0.0099369818377	0.285714285714	EIF2B3 EIF2B2 EIF2B4 EIF2B1	Amenorrhea
GO:0006412	0.0117725190576	0.5	EIF2B3 BZW2 EIF2B1 EIF2B4 BZW1 EIF2B5 EIF2B2	translation
GO:0002757	0.0128811908377	0.428571428571	EIF2B3 MAVS EIF2B1 EIF2B4 EIF2B5 EIF2B2	immune response-activating signaling pathway
GO:0043043	0.0143808860823	0.5	EIF2B3 BZW2 EIF2B1 EIF2B4 BZW1 EIF2B5 EIF2B2	peptide biosynthetic process
GO:0005085	0.0159143289061	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	guanyl-nucleotide exchange factor activity
GO:0002764	0.0178343195064	0.428571428571	EIF2B3 MAVS EIF2B1 EIF2B4 EIF2B5 EIF2B2	immune response-regulating signaling pathway
GO:0006446	0.0246687543338	0.285714285714	BZW1 EIF2B5 BZW2 EIF2B2	regulation of translational initiation
GO:0002253	0.0304830910984	0.428571428571	EIF2B3 MAVS EIF2B1 EIF2B4 EIF2B5 EIF2B2	activation of immune response
GO:0001541	0.0335980618564	0.214285714286	EIF2B2 EIF2B4 EIF2B5	ovarian follicle development
HP:0002352	0.0401413515502	0.285714285714	EIF2B3 EIF2B2 EIF2B4 EIF2B1	Leukoencephalopathy
GO:0002429	0.0423693430729	0.357142857143	EIF2B3 EIF2B2 EIF2B5 EIF2B4 EIF2B1	immune response-activating cell surface receptor signaling pathway
GO:0043604	0.0477501847784	0.5	EIF2B3 BZW2 EIF2B1 EIF2B4 BZW1 EIF2B5 EIF2B2	amide biosynthetic process

Edges

Protein 1	Protein 2	Score	ProteomeHD
EIF2B2	EIF2B5	1.0	0.882
EIF2B3	EIF2B5	1.0	0.932
EIF2B2	EIF2B3	1.0	0.878
EIF2B4	EIF2B2	1.0	0.38
EIF2B2	EIF2B1	1.0	0.538
EIF2B5	EIF2B1	1.0	0.57
EIF2B4	EIF2B5	1.0	0.472
BZW1	BZW2	0.999	0.286
EIF2B3	EIF2B1	0.999	0.324
EIF2B4	EIF2B1	0.998	0.094
EXOG	EIF2B2	0.998	0.028
EIF2B4	EIF2B3	0.997	0.436
EIF2B3	IPO9	0.995	0.312
EIF2B2	IPO9	0.989	0.16
SEC62	EIF2B3	0.989	0.066
EIF2B4	IPO9	0.987	0.142
IPO9	EIF2B1	0.987	0.236
IPO9	EIF2B5	0.985	0.278
BZW1	EIF2B4	0.983	0.11
EIF2B3	CIP2A	0.981	0.054
ASIC2	SEC62	0.979
BZW2	EIF2B3	0.979	0.12
SEC62	EIF2B5	0.978	0.096
PTAFR	SEC62	0.977
EIF2B2	PTAFR	0.977
BZW2	IPO9	0.974	0.234
SEC62	EIF2B1	0.973	0.0609655172414
GYPB	EIF2B4	0.972
GYPB	EIF2B3	0.972
BZW1	EIF2B5	0.972	0.152
GYPB	BZW1	0.971
EIF2B4	CIP2A	0.971	0.024
BZW2	EIF2B2	0.971	0.074
GYPB	EIF2B1	0.971
EXOG	EIF2B1	0.97	0.048
SPN	EIF2B1	0.969	0.054
EXOG	EIF2B5	0.969	0.044
EIF2B4	PTAFR	0.968
BZW2	EIF2B5	0.967	0.128
SPN	EIF2B3	0.965	0.024
BZW2	MAVS	0.962	0.028
EIF2B2	SPN	0.962	0.042
EIF2B4	SEC62	0.962	0.032
BZW1	EIF2B3	0.96	0.282
PTAFR	EIF2B5	0.959
CIP2A	IPO9	0.958	0.048
EIF2B2	SEC62	0.957	0.102
GYPB	SEC62	0.955
EIF2B4	BZW2	0.954	0.094
EIF2B4	SPN	0.949	0.074
BZW2	EXOG	0.946	0.022
SPN	EIF2B5	0.94	0.052
GYPB	EIF2B2	0.937
BZW1	EIF2B2	0.913	0.208
BZW2	EIF2B1	0.912	0.144
EIF2B2	CIP2A	0.892	0.042
BZW2	CIP2A	0.886	0.048
GYPB	BZW2	0.873
GYPB	EIF2B5	0.862
CIP2A	EIF2B5	0.753	0.068
SEC62	IPO9	0.749	0.036
BZW2	SEC62	0.702	0.03
CIP2A	EIF2B1	0.665	0.112
BZW1	EIF2B1	0.656	0.244
EXOG	EIF2B3	0.599	0.046
BZW1	CIP2A	0.541	0.054
SEC62	CIP2A	0.514	0.026
EXOG	SEC62	0.48	0.05
EIF2B4	EXOG	0.461	0.044
MAVS	SEC62	0.13	0.026
EXOG	MAVS	0.121	0.048
BZW1	IPO9	0.09	0.122
MAVS	EIF2B3	0.071	0.03
EXOG	CIP2A	0.062	0.032
BZW1	SEC62	0.051	0.056
BZW1	EXOG	0.031	0.046
EIF2B2	MAVS	0.031	0.058
MAVS	CIP2A	0.029	0.02
MAVS	EIF2B5	0.028	0.064
PTAFR	EIF2B1	0.021
PTAFR	EIF2B3	0.021
SPN	IPO9	0.02	0.022
EIF2B4	MAVS	0.019	0.026
BZW2	SPN	0.019	0.076
BZW1	MAVS	0.018	0.064
EXOG	IPO9	0.014	0.062
MAVS	IPO9	0.012	0.058
MAVS	EIF2B1	0.008	0.062
ASIC2	BZW1	0.007

Related Complexes

Genename	Complexes
GYPB	huMAP3_00951.1 huMAP3_03018.1 huMAP3_03231.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
BZW1	huMAP3_00951.1 huMAP3_01913.1 huMAP3_03018.1 huMAP3_03231.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_14489.1
EIF2B2	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08680.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EIF2B1	huMAP3_08485.1 huMAP3_08680.1 huMAP3_08968.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1
EIF2B3	huMAP3_03231.1 huMAP3_04876.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_12208.1
ASIC2	huMAP3_00129.1 huMAP3_02656.1 huMAP3_02911.1 huMAP3_03061.1 huMAP3_08031.1 huMAP3_08282.1 huMAP3_09416.1 huMAP3_10530.1 huMAP3_11089.1 huMAP3_11588.1 huMAP3_11974.1 huMAP3_12482.1 huMAP3_14990.1
SEC62	huMAP3_02911.1 huMAP3_07141.1 huMAP3_10530.1 huMAP3_11974.1
EIF2B4	huMAP3_00951.1 huMAP3_03018.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EXOG	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11700.1
BZW2	huMAP3_00951.1 huMAP3_02736.1 huMAP3_04876.1 huMAP3_06722.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
PTAFR	huMAP3_02469.1 huMAP3_02659.1 huMAP3_07141.1 huMAP3_08184.1 huMAP3_08680.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10287.1 huMAP3_10530.1
IPO9	huMAP3_03231.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08936.1 huMAP3_08968.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1
MAVS	huMAP3_02736.1 huMAP3_03898.1 huMAP3_05707.1 huMAP3_10530.1 huMAP3_11823.1 huMAP3_13227.1 huMAP3_14723.1
CIP2A	huMAP3_03231.1 huMAP3_05832.1 huMAP3_06130.1 huMAP3_08298.1 huMAP3_08301.1 huMAP3_08370.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1
SPN	huMAP3_02351.1 huMAP3_02659.1 huMAP3_03078.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08370.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EIF2B5	huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09399.1 huMAP3_09406.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_11977.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10530.1