hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10535.1
Complex Portal: CPX-15412
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLR6 | Toll-like receptor 6 (CD antigen CD286) | 5 | UniProt NCBI |
| FIGN | Fidgetin | 4 | UniProt NCBI |
| ALDH16A1 | Aldehyde dehydrogenase family 16 member A1 | 4 | UniProt NCBI |
| LANCL1 | Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) | 5 | UniProt NCBI |
| DERA | Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) | 5 | UniProt NCBI |
| MYO7A | Unconventional myosin-VIIa | 5 | UniProt NCBI |
| TLR1 | Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) | 5 | UniProt NCBI |
| PCMT1 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3877 | 0.00250295506608 | 0.25 | TLR6 TLR1 | MYD88 distinct input output pathway |
| REAC:R-HSA-5603041 | 0.00505983974502 | 0.25 | TLR6 TLR1 | IRAK4 deficiency (TLR2/4) |
| REAC:R-HSA-5602498 | 0.00505983974502 | 0.25 | TLR6 TLR1 | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5686938 | 0.00583667819665 | 0.25 | TLR6 TLR1 | Regulation of TLR by endogenous ligand |
| WP:WP3858 | 0.00833957037235 | 0.25 | TLR6 TLR1 | Toll like receptor signaling related to MyD88 |
| REAC:R-HSA-5602358 | 0.0194471683576 | 0.25 | TLR6 TLR1 | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.0194471683576 | 0.25 | TLR6 TLR1 | Diseases of Immune System |
| GO:0070340 | 0.0393180950424 | 0.25 | TLR6 TLR1 | detection of bacterial lipopeptide |
| KEGG:04620 | 0.0474398326563 | 0.25 | TLR6 TLR1 | Toll-like receptor signaling pathway |
| CORUM:6530 | 0.0499436884912 | 0.125 | MYO7A | MYO7A-PDZD7 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DERA | ALDH16A1 | 1.0 | 0.786 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction | |
| MYO7A | LANCL1 | 0.999 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TLR6 | TLR1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DERA | LANCL1 | 0.988 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DERA | TLR1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ALDH16A1 | TLR1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ALDH16A1 | PCMT1 | 0.977 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LANCL1 | FIGN | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DERA | PCMT1 | 0.964 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction | |
| ALDH16A1 | LANCL1 | 0.964 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ALDH16A1 | MYO7A | 0.781 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| DERA | MYO7A | 0.769 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| MYO7A | FIGN | 0.582 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ALDH16A1 | FIGN | 0.255 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DERA | FIGN | 0.21 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DERA | TLR6 | 0.193 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ALDH16A1 | TLR6 | 0.189 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PCMT1 | TLR1 | 0.011 | bioplex3_HEK293 bioplex () | ||
| PCMT1 | LANCL1 | 0.007 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| TLR1 | LANCL1 | 0.006 | bioplex3_HEK293 WMM_only | ||
| PCMT1 | FIGN | 0.005 | youn_WMM WMM_only | ||
| PCMT1 | TLR6 | 0.002 | bioplex3_HEK293 bioplex () |
Related Complexes