hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10537.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ESPL1 | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | 5 | UniProt NCBI |
| PTTG1 | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | 5 | UniProt NCBI |
| PJA2 | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | 5 | UniProt NCBI |
| DDX11 | ATP-dependent DNA helicase DDX11 (EC 3.6.4.12) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5642 | 5.12628525639e-06 | 0.5 | PTTG1 ESPL1 | Securin-separase complex |
| KEGG:04110 | 0.000191622909408 | 0.75 | PTTG1 ESPL1 DDX11 | Cell cycle |
| WP:WP4240 | 0.000232143427839 | 0.5 | PTTG1 ESPL1 | Regulation of sister chromatid separation at the metaphase anaphase transition |
| WP:WP5117 | 0.0011843872874 | 0.5 | PTTG1 ESPL1 | Cohesin complex Cornelia de Lange syndrome |
| KEGG:04114 | 0.0133093129958 | 0.5 | PTTG1 ESPL1 | Oocyte meiosis |
| WP:WP179 | 0.0168573248614 | 0.5 | PTTG1 ESPL1 | Cell cycle |
| KEGG:05166 | 0.0480473295333 | 0.5 | PTTG1 ESPL1 | Human T-cell leukemia virus 1 infection |
| CORUM:5643 | 0.049938562206 | 0.25 | ESPL1 | ESPL1-CDC2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ESPL1 | PTTG1 | 0.997 | 0.11 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| PJA2 | DDX11 | 0.964 | 0.118 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| DDX11 | ESPL1 | 0.954 | 0.176 | bioplex_WMM bioplex3_WMM WMM_only |
| PJA2 | ESPL1 | 0.072 | 0.122 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes