hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10555.1
Complex Portal: CPX-11441
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL17A1 | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | 5 | UniProt NCBI |
| COL4A4 | Collagen alpha-4(IV) chain | 5 | UniProt NCBI |
| COL6A3 | Collagen alpha-3(VI) chain | 5 | UniProt NCBI |
| LAIR2 | Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306) | 4 | UniProt NCBI |
| COL3A1 | Collagen alpha-1(III) chain | 5 | UniProt NCBI |
| C1QTNF1 | Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 1.26352756558e-05 | 0.6 | COL17A1 COL4A4 COL3A1 | Collagen chain trimerization |
| KEGG:04974 | 4.85636233593e-05 | 0.6 | COL17A1 COL4A4 COL3A1 | Protein digestion and absorption |
| REAC:R-HSA-2022090 | 5.03751582702e-05 | 0.6 | COL17A1 COL4A4 COL3A1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 5.72260849506e-05 | 0.6 | COL17A1 COL4A4 COL3A1 | Collagen degradation |
| REAC:R-HSA-1650814 | 6.86227830674e-05 | 0.6 | COL17A1 COL4A4 COL3A1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 0.00018480745401 | 0.6 | COL17A1 COL4A4 COL3A1 | Collagen formation |
| REAC:R-HSA-198933 | 0.000455699137987 | 0.6 | COL17A1 COL3A1 LAIR2 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| REAC:R-HSA-1474228 | 0.000578912790256 | 0.6 | COL17A1 COL4A4 COL3A1 | Degradation of the extracellular matrix |
| GO:0030020 | 0.00350285844735 | 0.6 | COL17A1 COL4A4 COL3A1 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-419037 | 0.00531742996423 | 0.4 | COL3A1 COL4A4 | NCAM1 interactions |
| REAC:R-HSA-1474244 | 0.00594422623006 | 0.6 | COL17A1 COL4A4 COL3A1 | Extracellular matrix organization |
| REAC:R-HSA-375165 | 0.0130168285242 | 0.4 | COL3A1 COL4A4 | NCAM signaling for neurite out-growth |
| KEGG:05146 | 0.0164241113683 | 0.4 | COL3A1 COL4A4 | Amoebiasis |
| KEGG:04933 | 0.0168082536599 | 0.4 | COL3A1 COL4A4 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-186797 | 0.0170393864121 | 0.4 | COL3A1 COL4A4 | Signaling by PDGF |
| REAC:R-HSA-3000171 | 0.0170393864121 | 0.4 | COL3A1 COL4A4 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 0.0249357389386 | 0.4 | COL3A1 COL4A4 | ECM proteoglycans |
| KEGG:04926 | 0.0258857078716 | 0.4 | COL3A1 COL4A4 | Relaxin signaling pathway |
| REAC:R-HSA-216083 | 0.0294410858888 | 0.4 | COL3A1 COL4A4 | Integrin cell surface interactions |
| HP:0001030 | 0.0297055420477 | 0.4 | COL17A1 COL3A1 | Fragile skin |
| HP:0001075 | 0.0337209222644 | 0.4 | COL17A1 COL3A1 | Atrophic scars |
| HP:0200020 | 0.0425110382594 | 0.4 | COL17A1 COL4A4 | Corneal erosion |
| HP:0002293 | 0.0497672375822 | 0.4 | COL17A1 COL3A1 | Alopecia of scalp |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COL4A4 | LAIR2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL6A3 | LAIR2 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL17A1 | LAIR2 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL3A1 | C1QTNF1 | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LAIR2 | COL3A1 | 0.974 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| COL17A1 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL4A4 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL3A1 | 0.25 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL3A1 | 0.214 | bioplex3_WMM WMM_only | ||
| COL6A3 | COL3A1 | 0.214 | 0.366 | bioplex3_WMM WMM_only |
Related Complexes