hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10560.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD50 | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | 5 | UniProt NCBI |
| FAM219A | Protein FAM219A | 3 | UniProt NCBI |
| ASTN2 | Astrotactin-2 | 5 | UniProt NCBI |
| FBXO10 | F-box only protein 10 | 5 | UniProt NCBI |
| NBN | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:173 | 4.09448956317e-05 | 0.4 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:1081 | 4.09448956317e-05 | 0.4 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:972 | 4.09448956317e-05 | 0.4 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:618 | 4.09448956317e-05 | 0.4 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:331 | 4.09448956317e-05 | 0.4 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:73 | 4.09448956317e-05 | 0.4 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:71 | 4.09448956317e-05 | 0.4 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:2767 | 4.09448956317e-05 | 0.4 | NBN RAD50 | RAD50-MRE11-NBN-p200-p350 complex |
| CORUM:964 | 8.18785830799e-05 | 0.4 | NBN RAD50 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:627 | 8.18785830799e-05 | 0.4 | NBN RAD50 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) |
| CORUM:619 | 8.18785830799e-05 | 0.4 | NBN RAD50 | MRE11A-RAD50-NBN-TRF2 complex |
| CORUM:202 | 8.18785830799e-05 | 0.4 | NBN RAD50 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:2218 | 8.18785830799e-05 | 0.4 | NBN RAD50 | MDC1-MRE11-RAD50-NBS1 complex |
| WP:WP2942 | 0.000123435780153 | 0.4 | NBN RAD50 | DDX1 as a regulatory component of the Drosha microprocessor |
| CORUM:1189 | 0.000136445626745 | 0.4 | NBN RAD50 | DNA double-strand break end-joining complex |
| CORUM:5197 | 0.000204640425412 | 0.4 | NBN RAD50 | PTIP-DNA damage response complex |
| CORUM:2217 | 0.000204640425412 | 0.4 | NBN RAD50 | MDC1-MRN-ATM-FANCD2 complex |
| REAC:R-HSA-5693548 | 0.000227895019208 | 0.4 | NBN RAD50 | Sensing of DNA Double Strand Breaks |
| WP:WP5118 | 0.00032310719867 | 0.4 | NBN RAD50 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome |
| CORUM:2815 | 0.00038189088864 | 0.4 | NBN RAD50 | BRCA1-BARD1-BACH1-DNA damage complex II |
| WP:WP186 | 0.0003876755558 | 0.4 | NBN RAD50 | Homologous recombination |
| REAC:R-HSA-5685939 | 0.000835043279679 | 0.4 | NBN RAD50 | HDR through MMEJ (alt-NHEJ) |
| CORUM:433 | 0.000899678549321 | 0.4 | NBN RAD50 | BASC complex (BRCA1-associated genome surveillance complex) |
| KEGG:03440 | 0.00352719256651 | 0.4 | NBN RAD50 | Homologous recombination |
| WP:WP2516 | 0.0041146517648 | 0.4 | NBN RAD50 | ATM signaling pathway |
| REAC:R-HSA-9709603 | 0.00418294558639 | 0.4 | NBN RAD50 | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9704331 | 0.00454605723789 | 0.4 | NBN RAD50 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9704646 | 0.00454605723789 | 0.4 | NBN RAD50 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9701192 | 0.00454605723789 | 0.4 | NBN RAD50 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9701193 | 0.00454605723789 | 0.4 | NBN RAD50 | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| WP:WP3878 | 0.00479747871248 | 0.4 | NBN RAD50 | ATM signaling in development and disease |
| REAC:R-HSA-5693554 | 0.00531742996423 | 0.4 | NBN RAD50 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| HP:0030406 | 0.00582689447108 | 0.4 | NBN RAD50 | Primary peritoneal carcinoma |
| WP:WP3959 | 0.00774618498599 | 0.4 | NBN RAD50 | DNA IR double strand breaks and cellular response via ATM |
| REAC:R-HSA-5693568 | 0.00799229651072 | 0.4 | NBN RAD50 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 0.00849065158197 | 0.4 | NBN RAD50 | Resolution of D-Loop Structures |
| REAC:R-HSA-9709570 | 0.00849065158197 | 0.4 | NBN RAD50 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 0.00900400267976 | 0.4 | NBN RAD50 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 0.0112072433688 | 0.4 | NBN RAD50 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9675136 | 0.0117954816348 | 0.4 | NBN RAD50 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 0.0117954816348 | 0.4 | NBN RAD50 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| WP:WP1530 | 0.0121292354685 | 0.4 | NBN RAD50 | miRNA regulation of DNA damage response |
| WP:WP707 | 0.0121292354685 | 0.4 | NBN RAD50 | DNA damage response |
| REAC:R-HSA-5693579 | 0.0130168285242 | 0.4 | NBN RAD50 | Homologous DNA Pairing and Strand Exchange |
| WP:WP4016 | 0.017034501082 | 0.4 | NBN RAD50 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-9675135 | 0.0177620315324 | 0.4 | NBN RAD50 | Diseases of DNA repair |
| HP:0011027 | 0.0207761643339 | 0.4 | NBN RAD50 | Abnormal fallopian tube morphology |
| REAC:R-HSA-5693571 | 0.0275944536635 | 0.4 | NBN RAD50 | Nonhomologous End-Joining (NHEJ) |
| GO:0031860 | 0.0280843539964 | 0.4 | NBN RAD50 | telomeric 3' overhang formation |
| REAC:R-HSA-5685942 | 0.0323221445549 | 0.4 | NBN RAD50 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-2559586 | 0.0333121022189 | 0.4 | NBN RAD50 | DNA Damage/Telomere Stress Induced Senescence |
| HP:0100787 | 0.0337209222644 | 0.4 | NBN RAD50 | Prostate neoplasm |
| HP:0012125 | 0.0337209222644 | 0.4 | NBN RAD50 | Prostate cancer |
| WP:WP4946 | 0.0366585107731 | 0.4 | NBN RAD50 | DNA repair pathways full network |
| REAC:R-HSA-5693565 | 0.0374197925333 | 0.4 | NBN RAD50 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0384836492499 | 0.4 | NBN RAD50 | DNA Double Strand Break Response |
| REAC:R-HSA-912446 | 0.0384836492499 | 0.4 | NBN RAD50 | Meiotic recombination |
| KEGG:04218 | 0.0433995507999 | 0.4 | NBN RAD50 | Cellular senescence |
| GO:0030870 | 0.0468008499735 | 0.4 | NBN RAD50 | Mre11 complex |
| HP:0008775 | 0.0472853555832 | 0.4 | NBN RAD50 | Abnormal prostate morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD50 | FAM219A | 0.997 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FAM219A | NBN | 0.974 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FBXO10 | FAM219A | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAD50 | ASTN2 | 0.955 | 0.094 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAD50 | NBN | 0.951 | 0.522 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| FBXO10 | NBN | 0.186 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only |
| FBXO10 | RAD50 | 0.099 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes