hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10569.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALDH1B1 | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) | 5 | UniProt NCBI |
| CLPP | ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp) | 5 | UniProt NCBI |
| ALDH1A2 | Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) | 5 | UniProt NCBI |
| ALDH2 | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004029 | 0.000139871762976 | 0.75 | ALDH2 ALDH1B1 ALDH1A2 | aldehyde dehydrogenase (NAD+) activity |
| GO:0004030 | 0.000174830724535 | 0.75 | ALDH2 ALDH1B1 ALDH1A2 | aldehyde dehydrogenase [NAD(P)+] activity |
| KEGG:00340 | 0.000263050611119 | 0.5 | ALDH1B1 ALDH2 | Histidine metabolism |
| KEGG:00770 | 0.000340650966461 | 0.5 | ALDH1B1 ALDH2 | Pantothenate and CoA biosynthesis |
| REAC:R-HSA-71384 | 0.000563428413222 | 0.5 | ALDH1B1 ALDH2 | Ethanol oxidation |
| KEGG:00053 | 0.000578341586214 | 0.5 | ALDH1B1 ALDH2 | Ascorbate and aldarate metabolism |
| KEGG:00410 | 0.000878377582941 | 0.5 | ALDH1B1 ALDH2 | beta-Alanine metabolism |
| WP:WP3996 | 0.00096305612306 | 0.5 | ALDH1A2 ALDH2 | Ethanol effects on histone modifications |
| KEGG:00380 | 0.0013205961284 | 0.5 | ALDH1B1 ALDH2 | Tryptophan metabolism |
| GO:0016620 | 0.00172575455775 | 0.75 | ALDH2 ALDH1B1 ALDH1A2 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| KEGG:00071 | 0.00194963326435 | 0.5 | ALDH1B1 ALDH2 | Fatty acid degradation |
| KEGG:00330 | 0.00225645669975 | 0.5 | ALDH1B1 ALDH2 | Arginine and proline metabolism |
| KEGG:00620 | 0.00225645669975 | 0.5 | ALDH1B1 ALDH2 | Pyruvate metabolism |
| KEGG:00280 | 0.0025855951209 | 0.5 | ALDH1B1 ALDH2 | Valine, leucine and isoleucine degradation |
| KEGG:00561 | 0.0034402616107 | 0.5 | ALDH1B1 ALDH2 | Glycerolipid metabolism |
| GO:0016903 | 0.0037914498893 | 0.75 | ALDH2 ALDH1B1 ALDH1A2 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| KEGG:00310 | 0.00412492963649 | 0.5 | ALDH1B1 ALDH2 | Lysine degradation |
| KEGG:00010 | 0.00471711368352 | 0.5 | ALDH1B1 ALDH2 | Glycolysis / Gluconeogenesis |
| KEGG:04936 | 0.0189154103852 | 0.5 | ALDH1B1 ALDH2 | Alcoholic liver disease |
| KEGG:01240 | 0.0220824431074 | 0.5 | ALDH1B1 ALDH2 | Biosynthesis of cofactors |
| CORUM:3988 | 0.0249718442456 | 0.25 | CLPP | ClpP complex, heptameric |
| REAC:R-HSA-211945 | 0.0297941212351 | 0.5 | ALDH1B1 ALDH2 | Phase I - Functionalization of compounds |
| CORUM:3992 | 0.049938562206 | 0.25 | CLPP | ClpXP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ALDH2 | ALDH1B1 | 0.993 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM |
| ALDH1A2 | ALDH2 | 0.97 | 0.206 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CLPP | ALDH2 | 0.967 | 0.212 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ALDH1A2 | ALDH1B1 | 0.031 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| CLPP | ALDH1B1 | 0.022 | 0.274 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CLPP | ALDH1A2 | 0.001 | 0.12 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes