hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10571.1
Complex Portal: CPX-21052
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NHLH2 | Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2) | 5 | UniProt NCBI |
| ID1 | DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1) | 5 | UniProt NCBI |
| MYF6 | Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4) | 5 | UniProt NCBI |
| ID3 | DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) | 5 | UniProt NCBI |
| FERD3L | Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist) | 5 | UniProt NCBI |
| TCF12 | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | 5 | UniProt NCBI |
| ID2 | DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2) | 5 | UniProt NCBI |
| TWIST1 | Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist) | 5 | UniProt NCBI |
| TWIST2 | Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) | 5 | UniProt NCBI |
| TCF4 | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | 5 | UniProt NCBI |
| NEUROD1 | Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3) | 5 | UniProt NCBI |
| TCF3 | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | 5 | UniProt NCBI |
| ASCL4 | Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9031628 | 1.60057643707e-06 | 0.363636363636 | TCF12 ID2 ID1 ID3 | NGF-stimulated transcription |
| GO:0006357 | 2.8968673153e-06 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of transcription by RNA polymerase II |
| GO:0006366 | 5.21186456064e-06 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | transcription by RNA polymerase II |
| WP:WP53 | 7.25737523784e-06 | 0.272727272727 | ID2 ID1 ID3 | ID signaling pathway |
| REAC:R-HSA-198725 | 1.39579030198e-05 | 0.363636363636 | TCF12 ID2 ID1 ID3 | Nuclear Events (kinase and transcription factor activation) |
| GO:0006355 | 7.53691247935e-05 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of DNA-templated transcription |
| GO:2001141 | 8.05603852332e-05 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of RNA biosynthetic process |
| GO:0006351 | 0.000127015524712 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | DNA-templated transcription |
| GO:0032774 | 0.000142880142753 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | RNA biosynthetic process |
| REAC:R-HSA-187037 | 0.000150415192905 | 0.363636363636 | TCF12 ID2 ID1 ID3 | Signaling by NTRK1 (TRKA) |
| WP:WP4239 | 0.000208518233568 | 0.363636363636 | TWIST1 ID1 TWIST2 ID2 | Epithelial to mesenchymal transition in colorectal cancer |
| GO:0051252 | 0.000258182136371 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of RNA metabolic process |
| REAC:R-HSA-166520 | 0.000287792570691 | 0.363636363636 | TCF12 ID2 ID1 ID3 | Signaling by NTRKs |
| WP:WP3596 | 0.00053693805875 | 0.181818181818 | ID1 ID2 | miR 517 relationship with ARCN1 and USP1 |
| GO:0034654 | 0.000568973562955 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | nucleobase-containing compound biosynthetic process |
| GO:0018130 | 0.000695422418697 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | heterocycle biosynthetic process |
| GO:0019438 | 0.00070360086061 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | aromatic compound biosynthetic process |
| GO:0019219 | 0.000706346376562 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of nucleobase-containing compound metabolic process |
| GO:1901362 | 0.000967632092806 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | organic cyclic compound biosynthetic process |
| GO:0000981 | 0.00111312392629 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 0.00138940104974 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| HP:0011317 | 0.00143002591111 | 0.181818181818 | TCF12 TWIST1 | Right unicoronal synostosis |
| KEGG:04350 | 0.0016554438896 | 0.272727272727 | ID2 ID1 ID3 | TGF-beta signaling pathway |
| GO:0003700 | 0.001813299608 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | DNA-binding transcription factor activity |
| GO:0000785 | 0.00256434752378 | 0.727272727273 | NEUROD1 MYF6 TWIST1 ID2 NHLH2 TCF12 ASCL4 FERD3L | chromatin |
| GO:0000976 | 0.00271274792502 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | transcription cis-regulatory region binding |
| GO:0001067 | 0.00273454528415 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | transcription regulatory region nucleic acid binding |
| GO:0016070 | 0.00308349463476 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | RNA metabolic process |
| GO:1990837 | 0.00391686651099 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | sequence-specific double-stranded DNA binding |
| GO:0032993 | 0.0040687875558 | 0.727272727273 | NEUROD1 MYF6 TWIST1 ID2 NHLH2 TCF12 ASCL4 FERD3L | protein-DNA complex |
| KEGG:04550 | 0.00432699044861 | 0.272727272727 | ID2 ID1 ID3 | Signaling pathways regulating pluripotency of stem cells |
| GO:0010468 | 0.00469739513727 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of gene expression |
| GO:0044271 | 0.0050969753096 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | cellular nitrogen compound biosynthetic process |
| GO:0010556 | 0.00661322725549 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of macromolecule biosynthetic process |
| GO:0043565 | 0.00684866398324 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | sequence-specific DNA binding |
| GO:0003690 | 0.00699563353286 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | double-stranded DNA binding |
| GO:0031326 | 0.00842368314941 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of cellular biosynthetic process |
| GO:0032502 | 0.00868924089237 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | developmental process |
| GO:0009889 | 0.00899012714611 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of biosynthetic process |
| HP:0011315 | 0.00999375104824 | 0.181818181818 | TCF12 TWIST1 | Unicoronal synostosis |
| GO:0090304 | 0.0119029444692 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | nucleic acid metabolic process |
| GO:0140416 | 0.012862104388 | 0.272727272727 | ID2 ID1 ID3 | transcription regulator inhibitor activity |
| GO:0051171 | 0.0210338225181 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of nitrogen compound metabolic process |
| GO:0080090 | 0.0275866537037 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | regulation of primary metabolic process |
| GO:0140110 | 0.0317432438074 | 0.727272727273 | NEUROD1 MYF6 TWIST1 NHLH2 TWIST2 TCF12 ASCL4 FERD3L | transcription regulator activity |
| REAC:R-HSA-525793 | 0.0364941063676 | 0.181818181818 | TCF12 MYF6 | Myogenesis |
| GO:0006139 | 0.0379532315546 | 1.0 | TWIST2 NEUROD1 MYF6 TWIST1 NHLH2 FERD3L TCF12 ID1 ASCL4 ID2 ID3 | nucleobase-containing compound metabolic process |
| GO:0005694 | 0.0433328582986 | 0.727272727273 | NEUROD1 MYF6 TWIST1 ID2 NHLH2 TCF12 ASCL4 FERD3L | chromosome |
| GO:0051090 | 0.0487625050341 | 0.454545454545 | NEUROD1 ID3 ID2 NHLH2 ID1 | regulation of DNA-binding transcription factor activity |
| HP:0009701 | 0.0498048563326 | 0.181818181818 | TCF12 TWIST1 | Metacarpal synostosis |
| CORUM:2937 | 0.049976851631 | 0.0909090909091 | TCF12 | PTF1-bHLH complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ID1 | ASCL4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NHLH2 | ID1 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FERD3L | TCF3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ASCL4 | ID2 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FERD3L | TCF12 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MYF6 | TCF12 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TCF12 | TCF3 | 0.995 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| TCF4 | ID1 | 0.994 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NHLH2 | TCF12 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TCF4 | TWIST2 | 0.994 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TCF4 | TWIST1 | 0.992 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TCF4 | ID2 | 0.989 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NHLH2 | TCF3 | 0.989 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ID1 | TCF12 | 0.988 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| TCF4 | ID3 | 0.987 | 0.078 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ASCL4 | TCF3 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ID2 | TCF3 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TCF12 | ASCL4 | 0.984 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCF12 | TWIST2 | 0.981 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCF4 | TCF12 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TCF4 | FERD3L | 0.98 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TCF4 | MYF6 | 0.974 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NEUROD1 | TCF3 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MYF6 | TCF3 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TWIST2 | TCF3 | 0.964 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCF4 | NEUROD1 | 0.957 | 0.102 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TCF12 | ID2 | 0.953 |
mutually_exclusive (Q6XD76)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| TCF12 | NEUROD1 | 0.945 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TCF4 | TCF3 | 0.942 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TWIST1 | TCF12 | 0.911 |
mutually_exclusive (Q8WVJ9)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| ID1 | TCF3 | 0.907 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| TCF4 | NHLH2 | 0.899 |
mutually_exclusive (P41134)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ID1 | ID2 | 0.831 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TWIST1 | TCF3 | 0.776 |
mutually_exclusive (Q8WVJ9)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| ID3 | ID2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TWIST1 | ID3 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ID3 | TWIST2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TWIST2 | ID2 | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ID3 | ID1 | 0.516 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| TWIST1 | ID2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TWIST1 | TWIST2 | 0.502 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| ID1 | TWIST2 | 0.363 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TWIST1 | ID1 | 0.359 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ID3 | TCF12 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ID3 | TCF3 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only |
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