hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10577.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBR5 | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | 5 | UniProt NCBI |
| DFFB | DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) | 5 | UniProt NCBI |
| DFFA | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | 5 | UniProt NCBI |
| HUWE1 | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-140342 | 0.000798898068561 | 0.5 | DFFB DFFA | Apoptosis induced DNA fragmentation |
| WP:WP314 | 0.00178944501344 | 0.5 | DFFB DFFA | Fas ligand pathway and stress induction of heat shock proteins |
| GO:1902511 | 0.0028092043205 | 0.5 | DFFB DFFA | negative regulation of apoptotic DNA fragmentation |
| GO:1903625 | 0.0028092043205 | 0.5 | DFFB DFFA | negative regulation of DNA catabolic process |
| WP:WP4298 | 0.0063063631888 | 0.5 | DFFB DFFA | Acute viral myocarditis |
| WP:WP254 | 0.00666804419641 | 0.5 | DFFB DFFA | Apoptosis |
| WP:WP1772 | 0.00761604886135 | 0.5 | DFFB DFFA | Apoptosis modulation and signaling |
| REAC:R-HSA-75153 | 0.0120053783973 | 0.5 | DFFB DFFA | Apoptotic execution phase |
| KEGG:04210 | 0.0177164397058 | 0.5 | DFFB DFFA | Apoptosis |
| KEGG:04120 | 0.0224124539322 | 0.5 | UBR5 HUWE1 | Ubiquitin mediated proteolysis |
| GO:1902510 | 0.0280843539964 | 0.5 | DFFB DFFA | regulation of apoptotic DNA fragmentation |
| GO:1903624 | 0.0280843539964 | 0.5 | DFFB DFFA | regulation of DNA catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DFFA | DFFB | 1.0 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UBR5 | DFFB | 0.959 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UBR5 | HUWE1 | 0.951 | bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM | |
| HUWE1 | DFFB | 0.433 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DFFA | UBR5 | 0.053 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| DFFA | HUWE1 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
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