hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10578.1

Complex Portal: CPX-12782

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
XPC	DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125)	5	UniProt NCBI
HLTF	Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)	5	UniProt NCBI
RPA3	Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)	5	UniProt NCBI
APLF	Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)	5	UniProt NCBI
HMCES	Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)	5	UniProt NCBI
PNKP	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	5	UniProt NCBI
RPA4	Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)	5	UniProt NCBI
RPA2	Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)	5	UniProt NCBI
RNF146	E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)	5	UniProt NCBI
RPA1	Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]	5	UniProt NCBI
TDP1	Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)	5	UniProt NCBI
PARP1	Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]	5	UniProt NCBI
CHD1L	Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1)	5	UniProt NCBI
PARP2	Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)	5	UniProt NCBI
MACROD1	ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)	5	UniProt NCBI
APTX	Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)	5	UniProt NCBI
XRCC6	X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)	5	UniProt NCBI
RPAIN	RPA-interacting protein (hRIP)	5	UniProt NCBI
POLB	DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)	5	UniProt NCBI
XRCC1	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	5	UniProt NCBI
LIG3	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0006974	6.84071679957e-15	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	DNA damage response
GO:0006281	2.15098983859e-13	0.777777777778	PARP1 LIG3 HLTF PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 APLF APTX RPA3 POLB	DNA repair
GO:0006259	1.83620323437e-12	0.833333333333	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 APLF APTX RPA3 POLB	DNA metabolic process
KEGG:03410	2.08754500573e-12	0.388888888889	PARP1 LIG3 POLB PNKP PARP2 TDP1 APTX	Base excision repair
REAC:R-HSA-73933	2.29780758524e-12	0.388888888889	PARP1 POLB PNKP PARP2 LIG3 RPA1 RPA3	Resolution of Abasic Sites (AP sites)
WP:WP4946	4.81775046284e-11	0.444444444444	PARP1 POLB PNKP PARP2 LIG3 XPC RPA1 RPA3	DNA repair pathways full network
GO:0033554	8.03322064092e-11	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	cellular response to stress
REAC:R-HSA-73894	1.62910415479e-10	0.555555555556	PARP1 LIG3 POLB PNKP PARP2 RPA3 XPC CHD1L RPA1 TDP1	DNA Repair
REAC:R-HSA-73884	7.27069104462e-10	0.388888888889	PARP1 POLB PNKP PARP2 LIG3 RPA1 RPA3	Base Excision Repair
REAC:R-HSA-5696399	1.37443985891e-09	0.388888888889	PARP1 PARP2 LIG3 XPC RPA1 CHD1L RPA3	Global Genome Nucleotide Excision Repair (GG-NER)
REAC:R-HSA-5696395	2.16721544894e-09	0.333333333333	PARP1 PARP2 XPC RPA1 CHD1L RPA3	Formation of Incision Complex in GG-NER
GO:0006302	7.53520060941e-09	0.555555555556	PARP1 LIG3 POLB PNKP PARP2 RPA3 RPA4 RPA1 APLF TDP1	double-strand break repair
GO:0090734	8.79236386574e-09	0.444444444444	PARP1 PNKP CHD1L PARP2 RPA4 RPA1 APLF RPA3	site of DNA damage
REAC:R-HSA-5696398	9.07887153606e-09	0.388888888889	PARP1 PARP2 LIG3 XPC RPA1 CHD1L RPA3	Nucleotide Excision Repair
GO:0003684	1.10859533197e-08	0.388888888889	PARP1 PNKP PARP2 APTX XPC RPA1 RPA3	damaged DNA binding
REAC:R-HSA-110373	2.49294856598e-08	0.277777777778	RPA1 PARP2 RPA3 POLB PARP1	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
WP:WP4752	2.55134521581e-08	0.277777777778	PNKP LIG3 PARP2 POLB PARP1	Base excision repair
WP:WP5114	2.6351130633e-08	0.333333333333	PARP1 LIG3 XPC RPA1 CHD1L RPA3	Nucleotide excision repair in xeroderma pigmentosum
CORUM:362	6.32531883213e-08	0.166666666667	PNKP POLB LIG3	DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex
CORUM:5243	6.32531883213e-08	0.166666666667	PNKP TDP1 LIG3	XRCC1-LIG3-PNK-TDP1 complex
GO:0006284	2.5725700867e-07	0.333333333333	PARP1 POLB PNKP LIG3 RPA1 RPA3	base-excision repair
REAC:R-HSA-5696400	3.4747721783e-07	0.277777777778	RPA1 PARP2 CHD1L RPA3 PARP1	Dual Incision in GG-NER
GO:0003697	9.77969174249e-07	0.388888888889	HMCES RPA3 XPC RPA4 RPA1 APTX TDP1	single-stranded DNA binding
GO:0006950	2.47260301402e-06	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	response to stress
CORUM:1004	5.28877021693e-06	0.166666666667	RPA1 RPA3 PARP1	RC complex during S-phase of cell cycle
REAC:R-HSA-5693532	7.47053937586e-06	0.333333333333	PARP1 PARP2 LIG3 RPA1 TDP1 RPA3	DNA Double-Strand Break Repair
CORUM:1005	7.54956890187e-06	0.166666666667	RPA1 RPA3 PARP1	RC complex during G2/M-phase of cell cycle
GO:0035861	1.42846528137e-05	0.333333333333	PARP1 PNKP RPA4 CHD1L APLF RPA3	site of double-strand break
GO:0000012	1.68308738937e-05	0.222222222222	APLF APTX TDP1 PARP1	single strand break repair
REAC:R-HSA-5649702	1.68934804991e-05	0.166666666667	PNKP POLB LIG3	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
REAC:R-HSA-110362	2.70087580457e-05	0.166666666667	PARP1 PARP2 POLB	POLB-Dependent Long Patch Base Excision Repair
GO:0005654	3.28944571662e-05	0.944444444444	RNF146 LIG3 HLTF PARP1 PNKP CHD1L PARP2 POLB TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 RPAIN	nucleoplasm
KEGG:03420	3.85578995602e-05	0.222222222222	XPC RPA3 RPA1 RPA4	Nucleotide excision repair
CORUM:7352	5.77699275587e-05	0.111111111111	PARP1 LIG3	PARP1-LIG3 complex
CORUM:5229	5.77699275587e-05	0.111111111111	RPA1 RPA3	RPA complex
REAC:R-HSA-5685939	7.93957060989e-05	0.166666666667	PARP1 PARP2 LIG3	HDR through MMEJ (alt-NHEJ)
GO:0140097	8.83839371352e-05	0.388888888889	HLTF LIG3 TDP1 CHD1L APLF APTX POLB	catalytic activity, acting on DNA
GO:0031981	9.67075799541e-05	0.944444444444	RNF146 LIG3 HLTF PARP1 PNKP CHD1L PARP2 POLB TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 RPAIN	nuclear lumen
REAC:R-HSA-5693538	0.000119531723502	0.277777777778	RPA1 PARP2 RPA3 LIG3 PARP1	Homology Directed Repair
KEGG:03430	0.000160921310359	0.166666666667	RPA1 RPA3 RPA4	Mismatch repair
GO:0006260	0.000187552224585	0.388888888889	PARP1 POLB PNKP LIG3 RPA4 RPA1 RPA3	DNA replication
HPA:0460672	0.000199977804641	0.777777777778	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	skin 1; melanocytes[>=Medium]
WP:WP4016	0.000243555597427	0.222222222222	RPA1 TDP1 POLB PARP1	DNA IR damage and cellular response via ATR
HPA:0610833	0.000292369180028	0.611111111111	LIG3 POLB HMCES PNKP RPAIN APTX XPC RPA4 CHD1L RPA1 RPA3	urinary bladder; urothelial cells[High]
CORUM:1086	0.000346113734644	0.111111111111	POLB LIG3	DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1
CORUM:1085	0.000346113734644	0.111111111111	POLB LIG3	DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1
CORUM:2222	0.000576435185563	0.111111111111	RPA1 RPA3	BLM complex II
CORUM:2738	0.000576435185563	0.111111111111	RPA1 RPA3	BLM complex II
GO:0005657	0.000609477468338	0.277777777778	HMCES PARP1 RPA3 RPA1 RPA4	replication fork
GO:0050896	0.000609755714354	1.0	RNF146 LIG3 HLTF HMCES PNKP CHD1L PARP2 POLB TDP1 XPC RPA4 PARP1 RPA1 MACROD1 APLF APTX RPA3 RPAIN	response to stimulus
GO:0006261	0.000611471081564	0.333333333333	PARP1 POLB PNKP LIG3 RPA4 RPA1	DNA-templated DNA replication
HPA:0380511	0.000614215849042	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	placenta; decidual cells[>=Low]
REAC:R-HSA-5651801	0.000635067062134	0.166666666667	RPA1 RPA3 POLB	PCNA-Dependent Long Patch Base Excision Repair
KEGG:03030	0.00064230953743	0.166666666667	RPA1 RPA3 RPA4	DNA replication
HPA:0620222	0.000666426017857	0.777777777778	RNF146 LIG3 HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	vagina; squamous epithelial cells[>=Medium]
KEGG:03440	0.000886063743212	0.166666666667	RPA1 RPA3 RPA4	Homologous recombination
REAC:R-HSA-5696397	0.00109485777023	0.166666666667	RPA1 RPA3 LIG3	Gap-filling DNA repair synthesis and ligation in GG-NER
HPA:0190222	0.00121574399119	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	esophagus; squamous epithelial cells[>=Medium]
HPA:0380512	0.00138059608993	0.722222222222	RNF146 LIG3 HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	placenta; decidual cells[>=Medium]
GO:0051716	0.00149962678758	0.944444444444	RNF146 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 PARP1 RPA1 MACROD1 APLF APTX RPA3 POLB	cellular response to stimulus
GO:0006289	0.0015427511468	0.277777777778	XPC RPA4 RPA3 RPA1 PNKP	nucleotide-excision repair
GO:0160002	0.00156505859778	0.166666666667	APLF PARP2 CHD1L	ADP-D-ribose modification-dependent protein binding
GO:0072572	0.00156505859778	0.166666666667	APLF PARP2 RNF146	poly-ADP-D-ribose binding
HPA:0330222	0.00163800690536	0.777777777778	PARP1 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 CHD1L RPA1 APTX RPA3 RPAIN	oral mucosa; squamous epithelial cells[>=Medium]
KEGG:03460	0.0016408961021	0.166666666667	RPA1 RPA3 RPA4	Fanconi anemia pathway
WP:WP466	0.00206566263373	0.166666666667	RPA1 RPA3 RPA4	DNA replication
CORUM:248	0.00206911536973	0.111111111111	RPA1 RPA3	BRAFT complex
WP:WP4753	0.00221887746378	0.166666666667	XPC RPA3 RPA1	Nucleotide excision repair
REAC:R-HSA-68962	0.00258123785128	0.166666666667	RPA1 RPA3 RPA4	Activation of the pre-replicative complex
REAC:R-HSA-110381	0.0026492656232	0.111111111111	POLB LIG3	Resolution of AP sites via the single-nucleotide replacement pathway
CORUM:244	0.00315653663219	0.111111111111	RPA1 RPA3	BRAFT complex
GO:0031974	0.00346049615217	0.944444444444	RNF146 LIG3 HLTF PARP1 PNKP CHD1L PARP2 POLB TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 RPAIN	membrane-enclosed lumen
GO:0043233	0.00346049615217	0.944444444444	RNF146 LIG3 HLTF PARP1 PNKP CHD1L PARP2 POLB TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 RPAIN	organelle lumen
GO:0070013	0.00346049615217	0.944444444444	RNF146 LIG3 HLTF PARP1 PNKP CHD1L PARP2 POLB TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 RPAIN	intracellular organelle lumen
REAC:R-HSA-5696394	0.00397573632974	0.166666666667	XPC PARP2 PARP1	DNA Damage Recognition in GG-NER
HPA:0380513	0.00429114479775	0.444444444444	PARP1 LIG3 PNKP RPAIN RPA3 RPA1 CHD1L APTX	placenta; decidual cells[High]
GO:0005694	0.00494806104796	0.611111111111	PARP1 HMCES PNKP CHD1L PARP2 APTX XPC RPA4 RPA1 APLF RPA3	chromosome
HPA:0340461	0.00507255112519	0.722222222222	RNF146 LIG3 POLB HMCES PNKP RPAIN APTX XPC RPA4 PARP1 CHD1L RPA1 RPA3	ovary; ovarian stroma cells[>=Low]
HPA:0630052	0.00520370931057	0.722222222222	RNF146 LIG3 POLB PARP1 PNKP RPAIN TDP1 XPC RPA4 CHD1L RPA1 APTX RPA3	cervix; glandular cells[>=Medium]
GO:0006139	0.00520874440205	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	nucleobase-containing compound metabolic process
HPA:0630051	0.00532411093728	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	cervix; glandular cells[>=Low]
HPA:0180052	0.00578390629379	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	epididymis; glandular cells[>=Medium]
GO:0043596	0.00644711978039	0.222222222222	RPA1 RPA3 PARP1 RPA4	nuclear replication fork
HPA:0420052	0.00646818570144	0.777777777778	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	salivary gland; glandular cells[>=Medium]
HPA:0050011	0.00662082467981	0.611111111111	RNF146 LIG3 PARP1 PNKP RPAIN APTX XPC RPA4 CHD1L RPA1 RPA3	breast; adipocytes[>=Low]
HPA:0600442	0.00741169222311	0.722222222222	RNF146 LIG3 POLB PARP1 PNKP PARP2 APTX HMCES RPA4 CHD1L RPA1 RPA3 RPAIN	tonsil; non-germinal center cells[>=Medium]
GO:0046483	0.00813268974171	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	heterocycle metabolic process
GO:0006725	0.00852786898045	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	cellular aromatic compound metabolic process
GO:0003677	0.0103976943025	0.611111111111	PARP1 HLTF HMCES PNKP PARP2 TDP1 XPC RPA4 RPA1 APTX RPA3	DNA binding
HPA:0610832	0.0113308282663	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	urinary bladder; urothelial cells[>=Medium]
HPA:0270351	0.0117751140226	0.777777777778	RNF146 LIG3 HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	kidney; cells in glomeruli[>=Low]
HPA:0620000	0.0117947505188	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	vagina
HPA:0620221	0.0117947505188	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	vagina; squamous epithelial cells[>=Low]
HPA:0050052	0.0118068976667	0.777777777778	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	breast; glandular cells[>=Medium]
HPA:0301373	0.0120611042221	0.333333333333	PARP1 PNKP LIG3 XPC RPA1 APTX	lung; alveolar cells type II[High]
HPA:0130202	0.0141467074396	0.666666666667	RNF146 POLB HMCES PNKP LIG3 APTX XPC RPA4 PARP1 CHD1L RPA1 RPA3	colon; endothelial cells[>=Medium]
GO:1901360	0.0147869028307	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	organic cyclic compound metabolic process
HPA:0270352	0.0156142084123	0.611111111111	RNF146 LIG3 PARP1 PNKP RPAIN APTX HMCES RPA4 CHD1L RPA1 RPA3	kidney; cells in glomeruli[>=Medium]
HPA:0440342	0.0159356327355	0.666666666667	RNF146 LIG3 POLB PARP1 PNKP RPAIN APTX XPC RPA4 CHD1L RPA1 RPA3	skeletal muscle; myocytes[>=Medium]
HPA:0050012	0.0167283018702	0.444444444444	PARP1 LIG3 PNKP RPAIN RPA3 RPA1 CHD1L APTX	breast; adipocytes[>=Medium]
HPA:0530711	0.0168389930685	0.777777777778	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	spleen; cells in red pulp[>=Low]
GO:0090304	0.0169654520491	0.833333333333	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 APLF APTX RPA3 POLB	nucleic acid metabolic process
GO:0006310	0.0171706378969	0.333333333333	PARP1 LIG3 HMCES RPA4 RPA1 RPA3	DNA recombination
HPA:0460671	0.0175995761442	0.777777777778	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	skin 1; melanocytes[>=Low]
WP:WP2446	0.0178009195173	0.166666666667	RPA1 HLTF RPA3	Retinoblastoma gene in cancer
REAC:R-HSA-6782210	0.0183581193475	0.166666666667	RPA1 RPA3 LIG3	Gap-filling DNA repair synthesis and ligation in TC-NER
HP:0003380	0.0183696141885	0.166666666667	LIG3 TDP1 APTX	Decreased number of peripheral myelinated nerve fibers
HPA:0330221	0.020341076386	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	oral mucosa; squamous epithelial cells[>=Low]
HPA:0330000	0.020341076386	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	oral mucosa
HPA:0301361	0.0206080666779	0.388888888889	PARP1 PNKP LIG3 XPC RPA1 CHD1L APTX	lung; alveolar cells type I[>=Low]
GO:0006287	0.0222599970629	0.166666666667	PNKP POLB LIG3	base-excision repair, gap-filling
GO:0006266	0.0222599970629	0.166666666667	APLF LIG3 PNKP	DNA ligation
GO:0005662	0.0222599970629	0.166666666667	RPA1 RPA3 RPA4	DNA replication factor A complex
HPA:0100201	0.0244227505724	0.722222222222	RNF146 LIG3 POLB HMCES PNKP PARP2 APTX XPC RPA4 PARP1 CHD1L RPA3 RPAIN	cerebral cortex; endothelial cells[>=Low]
HPA:0301371	0.0253024190278	0.444444444444	PARP1 PNKP PARP2 LIG3 XPC RPA1 CHD1L APTX	lung; alveolar cells type II[>=Low]
WP:WP3645	0.0256095578001	0.111111111111	PARP1 PARP2	NAD biosynthetic pathways
REAC:R-HSA-3108214	0.0262600241359	0.166666666667	XPC PARP1 RPA1	SUMOylation of DNA damage response and repair proteins
HPA:0040000	0.0282677849985	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	bone marrow
HPA:0040081	0.0282677849985	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	bone marrow; hematopoietic cells[>=Low]
GO:0034641	0.0288302601165	0.888888888889	PARP1 LIG3 HLTF HMCES PNKP CHD1L PARP2 TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 POLB	cellular nitrogen compound metabolic process
REAC:R-HSA-3371511	0.0289722176234	0.111111111111	RPA1 RPA3	HSF1 activation
HPA:0210052	0.0300255777145	0.722222222222	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 RPA1 APTX RPA3	fallopian tube; glandular cells[>=Medium]
HPA:0010000	0.0304470496229	0.666666666667	RNF146 HMCES PNKP LIG3 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	adipose tissue
HPA:0010011	0.0304470496229	0.666666666667	RNF146 HMCES PNKP LIG3 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	adipose tissue; adipocytes[>=Low]
REAC:R-HSA-6781827	0.0334539832774	0.166666666667	RPA1 RPA3 LIG3	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
HPA:0320102	0.0335413980565	0.722222222222	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 RPA1 APTX RPA3	nasopharynx; respiratory epithelial cells[>=Medium]
HPA:0301363	0.0354832411475	0.277777777778	XPC APTX RPA1 PARP1 PNKP	lung; alveolar cells type I[High]
HPA:0130201	0.0361779324088	0.777777777778	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	colon; endothelial cells[>=Low]
HPA:0590052	0.0367053925786	0.777777777778	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	thyroid gland; glandular cells[>=Medium]
REAC:R-HSA-5358606	0.0398882708783	0.111111111111	RPA1 RPA3	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
REAC:R-HSA-5358565	0.0398882708783	0.111111111111	RPA1 RPA3	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
REAC:R-HSA-69166	0.0398882708783	0.111111111111	RPA1 RPA3	Removal of the Flap Intermediate
HPA:0600221	0.0419914541603	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	tonsil; squamous epithelial cells[>=Low]
WP:WP531	0.0421936103681	0.111111111111	RPA1 RPA3	DNA mismatch repair
HP:0003431	0.0431213334309	0.166666666667	PNKP TDP1 LIG3	Decreased motor nerve conduction velocity
HPA:0390000	0.0443964968946	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	prostate
HPA:0390051	0.0443964968946	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	prostate; glandular cells[>=Low]
HPA:0570792	0.0447660132549	0.444444444444	PARP1 POLB PNKP LIG3 TDP1 RPA4 CHD1L APTX	testis; round or early spermatids[>=Medium]
GO:0005634	0.0449589173992	0.944444444444	RNF146 LIG3 HLTF PARP1 PNKP CHD1L PARP2 POLB TDP1 XPC RPA4 RPA1 MACROD1 APLF APTX RPA3 RPAIN	nucleus
WP:WP4673	0.0452965360202	0.166666666667	XPC POLB PARP1	Male infertility
REAC:R-HSA-69183	0.0459913485254	0.111111111111	RPA1 RPA3	Processive synthesis on the lagging strand
REAC:R-HSA-5358508	0.0459913485254	0.111111111111	RPA1 RPA3	Mismatch Repair
HPA:0190221	0.0460006119896	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	esophagus; squamous epithelial cells[>=Low]
HPA:0190000	0.0460006119896	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	esophagus
HPA:0170052	0.0470997668122	0.722222222222	RNF146 POLB HMCES PNKP LIG3 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3	endometrium 2; glandular cells[>=Medium]
HPA:0170051	0.047552030999	0.833333333333	RNF146 LIG3 POLB HMCES PNKP PARP2 TDP1 XPC RPA4 PARP1 CHD1L RPA1 APTX RPA3 RPAIN	endometrium 2; glandular cells[>=Low]
HP:0040131	0.0482176471165	0.166666666667	PNKP TDP1 LIG3	Abnormal motor nerve conduction velocity
HPA:0060102	0.0483020336454	0.722222222222	RNF146 LIG3 POLB HMCES PNKP RPAIN TDP1 XPC RPA4 PARP1 RPA1 APTX RPA3	bronchus; respiratory epithelial cells[>=Medium]
CORUM:212	0.0496617483143	0.0555555555556	LIG3	DNA ligase III-XRCC1 complex
CORUM:363	0.0496617483143	0.0555555555556	LIG3	DNA ligase III-XRCC1 complex
CORUM:365	0.0496617483143	0.0555555555556	LIG3	DNA ligase III-XRCC1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RPA3	RPA2	1.0	0.958	structurally_consistent (dimer)
RPA1	RPA2	1.0	0.802
RPA3	RPA1	1.0	0.658	mutually_exclusive (Q13156)
LIG3	XRCC1	1.0	0.55
POLB	XRCC1	0.999	0.084	mutually_exclusive (P35244)
POLB	PARP2	0.999	0.04
LIG3	POLB	0.999	0.1
RPA1	RPAIN	0.999	0.196
RPA2	RPAIN	0.999	0.208
RNF146	PARP2	0.999	0.088	structurally_consistent (dimer)
RPA1	RPA4	0.998		structurally_consistent (dimer)
LIG3	PNKP	0.998	0.18
XRCC6	APLF	0.998
XRCC6	RPA2	0.997	0.456
APLF	XPC	0.997
LIG3	APTX	0.997	0.136
APLF	PARP1	0.997
APLF	PARP2	0.997
RPAIN	RPA4	0.997
APLF	LIG3	0.996
LIG3	TDP1	0.996	0.0660385964912
XPC	RPA2	0.995	0.14
XRCC6	PARP1	0.995	0.55	structurally_consistent (dimer)
APLF	RPA2	0.995
APLF	RPA1	0.995
RPA3	RPA4	0.995		structurally_consistent (dimer)
XPC	RPA1	0.994	0.218
APLF	HLTF	0.994
PNKP	POLB	0.994	0.108
XPC	PARP2	0.993	0.032
PNKP	XRCC1	0.993	0.13
XPC	RPA3	0.993	0.156
APLF	POLB	0.993
HLTF	CHD1L	0.993	0.09
XPC	PARP1	0.992	0.363073394495
LIG3	PARP2	0.991	0.076
MACROD1	PARP1	0.991	0.166	structurally_consistent (dimer)
APLF	XRCC1	0.99
XPC	RPA4	0.99
POLB	APTX	0.99	0.134
RPA3	RPAIN	0.989	0.288
LIG3	RPA2	0.989	0.106
RNF146	CHD1L	0.988	0.06
HMCES	RPA1	0.988	0.08
XPC	CHD1L	0.988	0.024
POLB	TDP1	0.986	0.13
LIG3	RPA4	0.986		structurally_consistent (dimer)
RPA2	PARP1	0.985	0.424
XPC	RNF146	0.984	0.182	structurally_consistent (dimer)
HLTF	XPC	0.984	0.032
RPA2	PARP2	0.983	0.048
APLF	RPA3	0.983
RPAIN	PARP1	0.983	0.226
LIG3	PARP1	0.982	0.53
LIG3	XPC	0.981	0.164
MACROD1	RPA2	0.978	0.026
HLTF	RPA2	0.977	0.07
XPC	POLB	0.976	0.19
POLB	PARP1	0.974	0.313555555556
LIG3	HLTF	0.973	0.1
HLTF	RPA1	0.972	0.204166666667
RNF146	PARP1	0.972	0.216
RPA4	PARP1	0.97
XRCC6	PARP2	0.97	0.206
HMCES	RPA4	0.969
PARP2	CHD1L	0.966	0.054
XRCC6	CHD1L	0.966	0.198
HMCES	RPA2	0.965	0.166
MACROD1	XPC	0.964	0.022
HLTF	PARP1	0.963	0.482857142857
RPA1	CHD1L	0.962	0.204
LIG3	RPA3	0.962	0.12
XRCC6	LIG3	0.96	0.338
PNKP	APTX	0.958	0.13
CHD1L	PARP1	0.958	0.470310125952
HLTF	RPA3	0.957	0.048
RPA3	HMCES	0.957	0.072
XRCC1	APTX	0.951	0.166
LIG3	RPA1	0.951	0.202
MACROD1	PARP2	0.95	0.034	structurally_consistent (dimer)
XRCC1	CHD1L	0.943	0.102
XRCC1	RPA2	0.943	0.232
XRCC6	RPA4	0.937
XRCC6	XPC	0.932	0.314
RPA2	RPA4	0.931		mutually_exclusive (P35244)
RPA3	RNF146	0.92	0.148
LIG3	CHD1L	0.92	0.094
XRCC1	TDP1	0.918	0.172
RNF146	RPA2	0.91	0.112
XRCC1	PARP2	0.908	0.07
APLF	TDP1	0.904
HLTF	RNF146	0.903	0.094
RPA2	CHD1L	0.9	0.082
RPA3	PARP2	0.883	0.078
HLTF	POLB	0.878	0.036
PNKP	TDP1	0.862	0.12
XRCC6	RNF146	0.862	0.136
MACROD1	RPA1	0.841	0.052
RPA3	CHD1L	0.836	0.102
RPA1	RNF146	0.834	0.112
POLB	RPA1	0.825	0.112
POLB	RPA2	0.823	0.1
APLF	CHD1L	0.818
HMCES	PARP2	0.814	0.034
XRCC6	RPA3	0.808	0.612
XRCC6	XRCC1	0.807	0.336
XRCC6	POLB	0.794	0.302
HLTF	XRCC1	0.791	0.07
XPC	TDP1	0.787	0.05
PARP2	RPA4	0.786
TDP1	PARP2	0.785	0.092
TDP1	APTX	0.765	0.14
POLB	RPA3	0.737	0.106	structurally_consistent (dimer)
MACROD1	RPA3	0.734	0.052	mutually_exclusive (P41208)
XPC	HMCES	0.716	0.01
PNKP	PARP2	0.661	0.046
HLTF	PARP2	0.654	0.086
HMCES	RPAIN	0.643	0.034
XRCC6	MACROD1	0.63	0.2
PNKP	RPA2	0.624	0.1
XRCC6	RPA1	0.614	0.654
RPA1	PARP1	0.605	0.63
XRCC6	HLTF	0.561	0.106
RPA1	PARP2	0.555	0.11
XPC	XRCC1	0.515	0.126
LIG3	HMCES	0.515	0.052
LIG3	RPAIN	0.512	0.1
XPC	RPAIN	0.469	0.062
TDP1	RPA1	0.465	0.11
TDP1	RPA3	0.457	0.034
XRCC6	HMCES	0.433	0.08
XRCC1	RPA1	0.429	0.22
PARP2	PARP1	0.423	0.307277777778	mutually_exclusive (Q9BQ69)
TDP1	RPA2	0.379	0.042
XRCC6	PNKP	0.375	0.308
HMCES	PARP1	0.355	0.144333333333
APLF	APTX	0.353
LIG3	RNF146	0.345	0.064
TDP1	PARP1	0.314	0.214
LIG3	MACROD1	0.304	0.036
APLF	PNKP	0.297
PNKP	PARP1	0.292	0.338764705882
HLTF	RPAIN	0.283	0.078
XRCC1	RPA3	0.253	0.098	structurally_consistent (dimer)
RPA3	PARP1	0.242	0.42
XRCC1	PARP1	0.23	0.434955555556
PARP2	RPAIN	0.204	0.088
APTX	PARP2	0.179	0.096
APTX	RPA2	0.17	0.114
XRCC1	RNF146	0.164	0.14
POLB	CHD1L	0.115	0.064
XRCC6	TDP1	0.114	0.365333333333
XPC	PNKP	0.111	0.108
HLTF	TDP1	0.095	0.06
TDP1	CHD1L	0.094	0.17
POLB	HMCES	0.085	0.022
APLF	HMCES	0.082
HLTF	HMCES	0.072	0.046
PNKP	RPA1	0.071	0.106
XRCC1	HMCES	0.069	0.068
PNKP	HMCES	0.068	0.054
HLTF	MACROD1	0.067	0.036
XRCC6	RPAIN	0.067	0.232
HLTF	PNKP	0.053	0.042
XPC	APTX	0.051	0.116
HMCES	CHD1L	0.047	0.036
HLTF	APTX	0.037	0.044
RPA1	APTX	0.031	0.162
APTX	PARP1	0.03	0.42
HLTF	RPA4	0.024
RPA3	APTX	0.022	0.064
XRCC6	APTX	0.016	0.186
PNKP	RPA3	0.015	0.056

Related Complexes

Genename	Complexes
XPC	huMAP3_01511.1 huMAP3_02570.1 huMAP3_06287.1 huMAP3_08413.1 huMAP3_09211.1 huMAP3_09858.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
HLTF	huMAP3_01511.1 huMAP3_02570.1 huMAP3_06287.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_09858.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
RPA3	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
APLF	huMAP3_00669.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
HMCES	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13227.1 huMAP3_13854.1 huMAP3_14723.1
PNKP	huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_13854.1 huMAP3_14846.1
RPA4	huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
RPA2	huMAP3_03503.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
RNF146	huMAP3_02570.1 huMAP3_06287.1 huMAP3_08413.1 huMAP3_09211.1 huMAP3_09858.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
RPA1	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
TDP1	huMAP3_01586.1 huMAP3_02384.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_11442.1 huMAP3_12122.1 huMAP3_13854.1 huMAP3_14846.1
PARP1	huMAP3_09432.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
CHD1L	huMAP3_07080.1 huMAP3_08413.1 huMAP3_09211.1 huMAP3_10513.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
PARP2	huMAP3_06287.1 huMAP3_06600.1 huMAP3_08413.1 huMAP3_09211.1 huMAP3_09858.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
MACROD1	huMAP3_01511.1 huMAP3_03503.1 huMAP3_07481.1 huMAP3_08422.1 huMAP3_08778.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13399.1 huMAP3_13854.1 huMAP3_14846.1
APTX	huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_12091.1 huMAP3_13977.1 huMAP3_14505.1
XRCC6	huMAP3_00503.1 huMAP3_03073.1 huMAP3_07080.1 huMAP3_07130.1 huMAP3_07707.1 huMAP3_09649.1 huMAP3_10513.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
RPAIN	huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
POLB	huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_13854.1 huMAP3_14846.1
XRCC1	huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_13854.1 huMAP3_14846.1
LIG3	huMAP3_00669.1 huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10578.1

Complex Portal: CPX-12782