hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10580.1
Complex Portal: CPX-21322
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WNK3 | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | 5 | UniProt NCBI |
| KLHL12 | Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR) | 5 | UniProt NCBI |
| FBXL17 | F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) | 5 | UniProt NCBI |
| KLHL2 | Kelch-like protein 2 (Actin-binding protein Mayven) | 5 | UniProt NCBI |
| PIK3C2B | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | 5 | UniProt NCBI |
| KLHL3 | Kelch-like protein 3 | 5 | UniProt NCBI |
| KLHL17 | Kelch-like protein 17 (Actinfilin) | 5 | UniProt NCBI |
| TRIM8 | E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) | 5 | UniProt NCBI |
| FBXO33 | F-box only protein 33 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016567 | 0.00730404922177 | 0.666666666667 | KLHL2 FBXO33 TRIM8 KLHL3 FBXL17 KLHL12 | protein ubiquitination |
| GO:0032446 | 0.0156608922208 | 0.666666666667 | KLHL2 FBXO33 TRIM8 KLHL3 FBXL17 KLHL12 | protein modification by small protein conjugation |
| GO:0070647 | 0.0280697756258 | 0.666666666667 | KLHL2 FBXO33 TRIM8 KLHL3 FBXL17 KLHL12 | protein modification by small protein conjugation or removal |
| GO:0043687 | 0.0413349003112 | 0.666666666667 | KLHL2 FBXO33 TRIM8 KLHL3 FBXL17 KLHL12 | post-translational protein modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KLHL2 | KLHL3 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KLHL17 | KLHL3 | 0.996 |
mutually_exclusive (O95198)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| KLHL2 | KLHL17 | 0.996 |
mutually_exclusive (Q9UH77)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KLHL12 | KLHL2 | 0.993 |
mutually_exclusive (Q9UH77)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FBXL17 | KLHL2 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KLHL2 | TRIM8 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FBXL17 | KLHL3 | 0.987 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FBXL17 | KLHL17 | 0.982 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KLHL12 | KLHL3 | 0.981 |
mutually_exclusive (O95198)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| KLHL2 | FBXO33 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| WNK3 | KLHL2 | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KLHL2 | PIK3C2B | 0.964 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KLHL12 | FBXL17 | 0.908 | 0.122 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBXL17 | FBXO33 | 0.565 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TRIM8 | KLHL3 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WNK3 | TRIM8 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TRIM8 | FBXO33 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KLHL17 | TRIM8 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIK3C2B | TRIM8 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KLHL12 | TRIM8 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WNK3 | KLHL3 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FBXO33 | KLHL3 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FBXL17 | PIK3C2B | 0.165 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only | |
| WNK3 | FBXO33 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KLHL17 | FBXO33 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIK3C2B | KLHL17 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIK3C2B | KLHL3 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WNK3 | PIK3C2B | 0.164 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| WNK3 | KLHL17 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIK3C2B | FBXO33 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FBXL17 | TRIM8 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WNK3 | FBXL17 | 0.162 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL12 | KLHL17 | 0.142 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WNK3 | KLHL12 | 0.082 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL12 | FBXO33 | 0.043 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KLHL12 | PIK3C2B | 0.027 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes