hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10591.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EDRF1 | Erythroid differentiation-related factor 1 | 5 | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | 5 | UniProt NCBI |
| MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) | 5 | UniProt NCBI |
| TSSK6 | Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase) | 5 | UniProt NCBI |
| CDK11A | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | 5 | UniProt NCBI |
| CDC37L1 | Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) | 5 | UniProt NCBI |
| HSP90AA1 | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | 5 | UniProt NCBI |
| FKBP5 | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | 5 | UniProt NCBI |
| CDC37 | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | 5 | UniProt NCBI |
| STK35 | Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1) | 5 | UniProt NCBI |
| CDK15 | Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2) | 5 | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | 5 | UniProt NCBI |
| IKBKG | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | 5 | UniProt NCBI |
| UNC45B | Protein unc-45 homolog B (Unc-45B) (SMUNC45) | 5 | UniProt NCBI |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | 5 | UniProt NCBI |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | 5 | UniProt NCBI |
| A6NIL8 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5266 | 3.15194221324e-17 | 0.4375 | CHUK HSP90AA1 IKBKB MAP3K14 CDC37 HSP90AB1 IKBKG | TNF-alpha/NF-kappa B signaling complex 6 |
| CORUM:5286 | 8.98218201938e-12 | 0.3125 | CDC37 HSP90AB1 CHUK IKBKG HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 10 |
| CORUM:5234 | 2.17534197696e-10 | 0.25 | CDC37 HSP90AB1 IKBKB HSP90AA1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:5285 | 2.17534197696e-10 | 0.25 | CDC37 HSP90AB1 CHUK FKBP5 | TNF-alpha/NF-kappa B signaling complex 9 |
| CORUM:5269 | 6.52173794885e-10 | 0.25 | FKBP5 HSP90AB1 CDC37 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 8 |
| WP:WP262 | 2.28229731231e-09 | 0.3125 | HSP90AA1 CHUK IKBKB MAP3K14 IKBKG | Ebstein Barr virus LMP1 signaling |
| CORUM:5268 | 3.03947935885e-09 | 0.25 | FKBP5 HSP90AB1 CDC37 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5194 | 9.1064580738e-09 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| WP:WP231 | 2.56068618224e-08 | 0.375 | CHUK CDC37 IKBKB MAP3K14 HSP90AA1 IKBKG | TNF alpha signaling pathway |
| CORUM:2100 | 4.89338390935e-08 | 0.1875 | IKBKB MAP3K14 CHUK | CHUK-IKBKB-MAP3K14 complex |
| CORUM:2112 | 4.89338390935e-08 | 0.1875 | CDC37 HSP90AB1 HSP90AA1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:2121 | 4.89338390935e-08 | 0.1875 | IKBKB IKBKG CHUK | I-kappa-B kinase complex |
| CORUM:5844 | 4.89338390935e-08 | 0.1875 | IKBKB IKBKG CHUK | I-kappa-B kinase complex |
| WP:WP3849 | 5.25183104708e-08 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | MAPK and NFkB signaling pathways inhibited by Yersinia YopJ |
| CORUM:2118 | 1.95604750042e-07 | 0.1875 | IKBKB IKBKG CHUK | CHUK-ERC1-IKBKB-IKBKG |
| REAC:R-HSA-5603027 | 3.14779081888e-07 | 0.1875 | IKBKB IKBKG CHUK | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) |
| REAC:R-HSA-5602636 | 3.14779081888e-07 | 0.1875 | IKBKB IKBKG CHUK | IKBKB deficiency causes SCID |
| CORUM:2105 | 4.88685573808e-07 | 0.1875 | IKBKB MAP3K14 CHUK | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| CORUM:2727 | 4.88685573808e-07 | 0.1875 | IKBKB IKBKG CHUK | SRC-3 complex |
| KEGG:04151 | 5.95955415928e-07 | 0.4375 | CHUK HSP90AA1 IKBKB CDC37 STK11 HSP90AB1 IKBKG | PI3K-Akt signaling pathway |
| WP:WP4172 | 7.70526994113e-07 | 0.4375 | CHUK HSP90AA1 IKBKB CDC37 STK11 HSP90AB1 IKBKG | PI3K Akt signaling pathway |
| KEGG:04657 | 8.81038178526e-07 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | IL-17 signaling pathway |
| WP:WP1433 | 1.57162465205e-06 | 0.25 | HSP90AA1 IKBKB IKBKG CHUK | Nucleotide binding oligomerization domain NOD pathway |
| KEGG:04659 | 1.94380532513e-06 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | Th17 cell differentiation |
| KEGG:05215 | 1.94380532513e-06 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | Prostate cancer |
| CORUM:5212 | 2.73116455234e-06 | 0.1875 | CDC37 HSP90AB1 HSP90AA1 | Kinase maturation complex 2 |
| REAC:R-HSA-168928 | 3.79891371655e-06 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| WP:WP4479 | 4.18469802888e-06 | 0.1875 | IKBKB IKBKG CHUK | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP4562 | 6.69104901464e-06 | 0.1875 | IKBKB IKBKG CHUK | Canonical NF kB pathway |
| WP:WP4480 | 6.69104901464e-06 | 0.1875 | IKBKB IKBKG CHUK | Altered glycosylation of MUC1 in tumor microenvironment |
| KEGG:05418 | 7.285444495e-06 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | Fluid shear stress and atherosclerosis |
| WP:WP288 | 1.00298761784e-05 | 0.1875 | IKBKB IKBKG CHUK | Nod like receptor NLR signaling pathway |
| REAC:R-HSA-5603029 | 1.09878913156e-05 | 0.1875 | IKBKB IKBKG CHUK | IkBA variant leads to EDA-ID |
| WP:WP2795 | 1.16434875531e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Cardiac hypertrophic response |
| WP:WP3932 | 1.73823614138e-05 | 0.375 | HSP90AA1 IKBKB CDC37 STK11 HSP90AB1 IKBKG | Focal adhesion PI3K Akt mTOR signaling pathway |
| CORUM:6344 | 1.76816091806e-05 | 0.1875 | IKBKB IKBKG CHUK | TNF-R1-associated signaling complex |
| WP:WP1434 | 1.96752574304e-05 | 0.1875 | IKBKB MAP3K14 CHUK | Osteopontin signaling |
| WP:WP195 | 2.01613716702e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | IL 1 signaling pathway |
| WP:WP3863 | 2.19390505538e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| KEGG:04621 | 2.20238721402e-05 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | NOD-like receptor signaling pathway |
| CORUM:5199 | 2.71661812985e-05 | 0.1875 | CDC37 HSP90AB1 HSP90AA1 | Kinase maturation complex 1 |
| REAC:R-HSA-9705671 | 2.88479780654e-05 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| WP:WP5072 | 3.02413294097e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Modulators of TCR signaling and T cell activation |
| KEGG:04920 | 3.25502738843e-05 | 0.25 | IKBKB CHUK STK11 IKBKG | Adipocytokine signaling pathway |
| KEGG:05120 | 3.25502738843e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Epithelial cell signaling in Helicobacter pylori infection |
| GO:0004674 | 3.49680224568e-05 | 0.5 | CDK11A CDK15 TSSK6 STK11 IKBKB CHUK MAP3K14 STK35 | protein serine/threonine kinase activity |
| REAC:R-HSA-168643 | 4.44553408425e-05 | 0.25 | HSP90AB1 IKBKB IKBKG CHUK | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| CORUM:2101 | 5.10764421909e-05 | 0.125 | IKBKB CHUK | IKKA-IKKB complex |
| CORUM:5849 | 5.10764421909e-05 | 0.125 | HSP90AB1 CDC37 | HSP90-CDC37-LRRK2 complex |
| CORUM:6152 | 5.10764421909e-05 | 0.125 | IKBKG CHUK | IKBKG-CHUK complex |
| CORUM:2104 | 5.10764421909e-05 | 0.125 | IKBKB MAP3K14 | IKKB-NIK complex |
| CORUM:5829 | 5.10764421909e-05 | 0.125 | IKBKG CHUK | IKBKG-CHUK complex |
| CORUM:5828 | 5.10764421909e-05 | 0.125 | IKBKB IKBKG | IKBKG-IKBKB complex |
| REAC:R-HSA-933543 | 5.16619332528e-05 | 0.1875 | IKBKB IKBKG CHUK | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| WP:WP69 | 5.36111964827e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | T cell receptor signaling pathway |
| KEGG:05417 | 6.22143531759e-05 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | Lipid and atherosclerosis |
| CORUM:5233 | 7.44083563759e-05 | 0.1875 | IKBKB IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex 5 |
| KEGG:04064 | 8.54636878428e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | NF-kappa B signaling pathway |
| WP:WP1544 | 8.83453181016e-05 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | MicroRNAs in cardiomyocyte hypertrophy |
| REAC:R-HSA-937039 | 8.94278778148e-05 | 0.1875 | IKBKB IKBKG CHUK | IRAK1 recruits IKK complex |
| REAC:R-HSA-975144 | 8.94278778148e-05 | 0.1875 | IKBKB IKBKG CHUK | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| WP:WP4961 | 9.68494643787e-05 | 0.1875 | IKBKB IKBKG CHUK | STING pathway in Kawasaki like disease and COVID 19 |
| KEGG:04625 | 0.000109053319748 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | C-type lectin receptor signaling pathway |
| REAC:R-HSA-5684264 | 0.000113741345606 | 0.1875 | IKBKB IKBKG CHUK | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| WP:WP712 | 0.000135123864288 | 0.1875 | IKBKB IKBKG CHUK | Estrogen signaling pathway |
| WP:WP4482 | 0.000135123864288 | 0.1875 | IKBKB IKBKG CHUK | Vitamin D in inflammatory diseases |
| CORUM:6512 | 0.000153131458895 | 0.125 | HSP90AA1 CDC37 | ILK-HSP90-CDC37 complex |
| KEGG:01523 | 0.000163485663022 | 0.1875 | IKBKB IKBKG CHUK | Antifolate resistance |
| KEGG:04668 | 0.000170337145875 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | TNF signaling pathway |
| REAC:R-HSA-1810476 | 0.000174753213031 | 0.1875 | IKBKB IKBKG CHUK | RIP-mediated NFkB activation via ZBP1 |
| REAC:R-HSA-9758274 | 0.000174753213031 | 0.1875 | IKBKB IKBKG CHUK | Regulation of NF-kappa B signaling |
| KEGG:05132 | 0.000182595864579 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | Salmonella infection |
| KEGG:04660 | 0.000235318472041 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | T cell receptor signaling pathway |
| REAC:R-HSA-1606322 | 0.000254300640386 | 0.1875 | IKBKB IKBKG CHUK | ZBP1(DAI) mediated induction of type I IFNs |
| WP:WP3851 | 0.000271709825145 | 0.1875 | IKBKB IKBKG CHUK | TLR4 signaling and tolerance |
| GO:1902911 | 0.000291729047535 | 0.375 | CHUK IKBKB TSSK6 STK11 IKBKG CDK11A | protein kinase complex |
| REAC:R-HSA-168927 | 0.000301780479361 | 0.1875 | IKBKB IKBKG CHUK | TICAM1, RIP1-mediated IKK complex recruitment |
| WP:WP5113 | 0.000306945242601 | 0.1875 | IKBKB IKBKG CHUK | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| GO:0004672 | 0.000329874995201 | 0.5 | CDK11A CDK15 TSSK6 STK11 IKBKB CHUK MAP3K14 STK35 | protein kinase activity |
| WP:WP3858 | 0.000345082930715 | 0.1875 | IKBKB IKBKG CHUK | Toll like receptor signaling related to MyD88 |
| REAC:R-HSA-937041 | 0.000354798918512 | 0.1875 | IKBKB IKBKG CHUK | IKK complex recruitment mediated by RIP1 |
| KEGG:04380 | 0.000365056922 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Osteoclast differentiation |
| REAC:R-HSA-9705683 | 0.000380186005893 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | SARS-CoV-2-host interactions |
| WP:WP2112 | 0.000386234928838 | 0.1875 | IKBKB MAP3K14 IKBKG | IL 17 signaling pathway |
| WP:WP4481 | 0.000386234928838 | 0.1875 | IKBKB IKBKG CHUK | Resistin as a regulator of inflammation |
| REAC:R-HSA-933542 | 0.000413655823822 | 0.1875 | IKBKB IKBKG CHUK | TRAF6 mediated NF-kB activation |
| WP:WP4880 | 0.00043051296929 | 0.1875 | IKBKB IKBKG CHUK | Host pathogen interaction of human coronaviruses interferon induction |
| KEGG:04210 | 0.000432340143369 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Apoptosis |
| WP:WP4496 | 0.000478028477874 | 0.1875 | IKBKB MAP3K14 CHUK | Signal transduction through IL1R |
| KEGG:04936 | 0.000492442785156 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Alcoholic liver disease |
| CORUM:2055 | 0.000509786398016 | 0.125 | IKBKB CHUK | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| WP:WP4329 | 0.000528892574384 | 0.1875 | IKBKB IKBKG CHUK | miRNA role in immune response in sepsis |
| REAC:R-HSA-9013418 | 0.000550080420295 | 0.1875 | CDC37 HSP90AB1 HSP90AA1 | RHOBTB2 GTPase cycle |
| WP:WP4136 | 0.000641109483352 | 0.1875 | IKBKB IKBKG CHUK | Fibrin complement receptor 3 signaling pathway |
| REAC:R-HSA-5607764 | 0.000676213663681 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | CLEC7A (Dectin-1) signaling |
| GO:0006457 | 0.000714783931934 | 0.375 | UNC45B CDC37L1 HSP90AA1 FKBP5 CDC37 HSP90AB1 | protein folding |
| WP:WP2036 | 0.000837309711855 | 0.1875 | IKBKB MAP3K14 CHUK | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-5602358 | 0.000906094946732 | 0.1875 | IKBKB IKBKG CHUK | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.000906094946732 | 0.1875 | IKBKB IKBKG CHUK | Diseases of Immune System |
| GO:0008385 | 0.0010743908712 | 0.1875 | IKBKB IKBKG CHUK | IkappaB kinase complex |
| WP:WP2637 | 0.00144048370603 | 0.1875 | IKBKB MAP3K14 CHUK | Interleukin 1 IL 1 structural pathway |
| GO:0016773 | 0.00152012798781 | 0.5 | CDK11A CDK15 TSSK6 STK11 IKBKB CHUK MAP3K14 STK35 | phosphotransferase activity, alcohol group as acceptor |
| REAC:R-HSA-5357956 | 0.00153136851945 | 0.1875 | IKBKB IKBKG CHUK | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-168638 | 0.00153136851945 | 0.1875 | IKBKB IKBKG CHUK | NOD1/2 Signaling Pathway |
| GO:0031072 | 0.00163862788909 | 0.3125 | CDC37 HSP90AB1 UNC45B CDC37L1 FKBP5 | heat shock protein binding |
| WP:WP2018 | 0.00176831553253 | 0.1875 | IKBKB IKBKG CHUK | RANKL RANK signaling pathway |
| REAC:R-HSA-9665245 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to tesevatinib |
| REAC:R-HSA-9665244 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to sapitinib |
| REAC:R-HSA-9665233 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to trastuzumab |
| REAC:R-HSA-9665246 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to neratinib |
| REAC:R-HSA-9665230 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Drug resistance in ERBB2 KD mutants |
| REAC:R-HSA-9665737 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Drug resistance in ERBB2 TMD/JMD mutants |
| REAC:R-HSA-9652282 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Drug-mediated inhibition of ERBB2 signaling |
| REAC:R-HSA-9665250 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to AEE788 |
| REAC:R-HSA-9665247 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to osimertinib |
| REAC:R-HSA-9665249 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to afatinib |
| REAC:R-HSA-9665251 | 0.00196885406049 | 0.125 | HSP90AA1 CDC37 | Resistance of ERBB2 KD mutants to lapatinib |
| KEGG:05221 | 0.00199958579372 | 0.1875 | IKBKB IKBKG CHUK | Acute myeloid leukemia |
| REAC:R-HSA-9706574 | 0.00201668364083 | 0.1875 | CDC37 HSP90AB1 HSP90AA1 | RHOBTB GTPase Cycle |
| REAC:R-HSA-5621481 | 0.00213136105766 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | C-type lectin receptors (CLRs) |
| KEGG:05169 | 0.00213968018554 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Epstein-Barr virus infection |
| REAC:R-HSA-445989 | 0.00219855006212 | 0.1875 | IKBKB IKBKG CHUK | TAK1-dependent IKK and NF-kappa-B activation |
| CORUM:5193 | 0.00228672316852 | 0.125 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5230 | 0.00228672316852 | 0.125 | IKBKG CHUK | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| REAC:R-HSA-9694516 | 0.00236554148333 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | SARS-CoV-2 Infection |
| GO:0016301 | 0.00262663220762 | 0.5 | CDK11A CDK15 TSSK6 STK11 IKBKB CHUK MAP3K14 STK35 | kinase activity |
| KEGG:04622 | 0.00267595468079 | 0.1875 | IKBKB IKBKG CHUK | RIG-I-like receptor signaling pathway |
| WP:WP3865 | 0.0028740185631 | 0.1875 | IKBKB IKBKG CHUK | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04662 | 0.00306409576108 | 0.1875 | IKBKB IKBKG CHUK | B cell receptor signaling pathway |
| KEGG:05166 | 0.00310517848782 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Human T-cell leukemia virus 1 infection |
| KEGG:04623 | 0.00334233968543 | 0.1875 | IKBKB IKBKG CHUK | Cytosolic DNA-sensing pathway |
| KEGG:05208 | 0.00335696412718 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | Chemical carcinogenesis - reactive oxygen species |
| KEGG:05212 | 0.0036366648212 | 0.1875 | IKBKB IKBKG CHUK | Pancreatic cancer |
| WP:WP5293 | 0.00375423346127 | 0.1875 | IKBKB IKBKG CHUK | Acute myeloid leukemia |
| KEGG:05220 | 0.00394749241248 | 0.1875 | IKBKB IKBKG CHUK | Chronic myeloid leukemia |
| KEGG:04658 | 0.00394749241248 | 0.1875 | IKBKB IKBKG CHUK | Th1 and Th2 cell differentiation |
| REAC:R-HSA-5357905 | 0.00405636849308 | 0.1875 | IKBKB IKBKG CHUK | Regulation of TNFR1 signaling |
| GO:0051604 | 0.00424391646733 | 0.4375 | UNC45B CDC37L1 HSP90AA1 FKBP5 CDC37 IKBKB HSP90AB1 | protein maturation |
| GO:1990459 | 0.00450341440411 | 0.1875 | IKBKB IKBKG CHUK | transferrin receptor binding |
| WP:WP3303 | 0.00457370653334 | 0.1875 | IKBKB IKBKG CHUK | RAC1 PAK1 p38 MMP2 pathway |
| CORUM:5232 | 0.00461246285552 | 0.125 | IKBKG CHUK | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| REAC:R-HSA-5336415 | 0.00491585006603 | 0.125 | HSP90AB1 HSP90AA1 | Uptake and function of diphtheria toxin |
| KEGG:05235 | 0.00498316601164 | 0.1875 | IKBKB IKBKG CHUK | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP4655 | 0.00502411981271 | 0.1875 | IKBKB IKBKG CHUK | Cytosolic DNA sensing pathway |
| KEGG:05200 | 0.00507404086882 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | Pathways in cancer |
| WP:WP2034 | 0.00575285685209 | 0.1875 | IKBKB IKBKG CHUK | Leptin signaling pathway |
| WP:WP382 | 0.00618199762786 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | MAPK signaling pathway |
| KEGG:05222 | 0.00618229448471 | 0.1875 | IKBKB IKBKG CHUK | Small cell lung cancer |
| KEGG:04620 | 0.00639881474911 | 0.1875 | IKBKB IKBKG CHUK | Toll-like receptor signaling pathway |
| KEGG:05142 | 0.00662023130172 | 0.1875 | IKBKB IKBKG CHUK | Chagas disease |
| REAC:R-HSA-3371497 | 0.00673271767195 | 0.1875 | FKBP5 HSP90AB1 HSP90AA1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| KEGG:04010 | 0.00687683933186 | 0.25 | IKBKB CHUK MAP3K14 IKBKG | MAPK signaling pathway |
| WP:WP254 | 0.00711572653326 | 0.1875 | IKBKB IKBKG CHUK | Apoptosis |
| REAC:R-HSA-75893 | 0.00713191639651 | 0.1875 | IKBKB IKBKG CHUK | TNF signaling |
| KEGG:05145 | 0.00731435978652 | 0.1875 | IKBKB IKBKG CHUK | Toxoplasmosis |
| WP:WP5098 | 0.00741143898378 | 0.1875 | IKBKB IKBKG CHUK | T cell activation SARS CoV 2 |
| KEGG:04915 | 0.0075558618527 | 0.1875 | FKBP5 HSP90AB1 HSP90AA1 | Estrogen signaling pathway |
| WP:WP23 | 0.00802678930148 | 0.1875 | IKBKB IKBKG CHUK | B cell receptor signaling pathway |
| GO:0097110 | 0.00830354723909 | 0.25 | HSP90AA1 IKBKB CHUK CDC37 | scaffold protein binding |
| REAC:R-HSA-450294 | 0.00842231031865 | 0.1875 | IKBKB IKBKG CHUK | MAP kinase activation |
| GO:1902554 | 0.00890145696994 | 0.3125 | IKBKG CHUK IKBKB CDK11A STK11 | serine/threonine protein kinase complex |
| WP:WP4263 | 0.00970927727994 | 0.1875 | IKBKB IKBKG CHUK | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-1834949 | 0.00985760715853 | 0.1875 | IKBKB IKBKG CHUK | Cytosolic sensors of pathogen-associated DNA |
| WP:WP75 | 0.0104419487965 | 0.1875 | IKBKB IKBKG CHUK | Toll like receptor signaling pathway |
| REAC:R-HSA-9679506 | 0.0110922012236 | 0.3125 | HSP90AB1 CHUK IKBKB IKBKG HSP90AA1 | SARS-CoV Infections |
| REAC:R-HSA-448424 | 0.0114450917712 | 0.1875 | IKBKB IKBKG CHUK | Interleukin-17 signaling |
| GO:0016772 | 0.0115131883451 | 0.5 | CDK11A CDK15 TSSK6 STK11 IKBKB CHUK MAP3K14 STK35 | transferase activity, transferring phosphorus-containing groups |
| REAC:R-HSA-9634285 | 0.0117754515762 | 0.125 | HSP90AA1 CDC37 | Constitutive Signaling by Overexpressed ERBB2 |
| WP:WP4658 | 0.0128545189686 | 0.1875 | IKBKB IKBKG CHUK | Small cell lung cancer |
| REAC:R-HSA-1169091 | 0.0131919871106 | 0.1875 | IKBKB IKBKG CHUK | Activation of NF-kappaB in B cells |
| KEGG:04068 | 0.0138911555021 | 0.1875 | IKBKB STK11 CHUK | FoxO signaling pathway |
| KEGG:05135 | 0.0146291699276 | 0.1875 | IKBKB IKBKG CHUK | Yersinia infection |
| WP:WP2882 | 0.0146313823273 | 0.25 | FKBP5 HSP90AB1 CDC37 HSP90AA1 | Nuclear receptors meta pathway |
| GO:0061695 | 0.0146750028311 | 0.375 | CHUK IKBKB TSSK6 STK11 IKBKG CDK11A | transferase complex, transferring phosphorus-containing groups |
| KEGG:05162 | 0.0182647337957 | 0.1875 | IKBKB IKBKG CHUK | Measles |
| REAC:R-HSA-1168372 | 0.019460445051 | 0.1875 | IKBKB IKBKG CHUK | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-2871837 | 0.0202577613109 | 0.1875 | IKBKB IKBKG CHUK | FCERI mediated NF-kB activation |
| KEGG:05160 | 0.0214634491342 | 0.1875 | IKBKB IKBKG CHUK | Hepatitis C |
| REAC:R-HSA-5637810 | 0.021546998337 | 0.125 | HSP90AA1 CDC37 | Constitutive Signaling by EGFRvIII |
| REAC:R-HSA-3371511 | 0.021546998337 | 0.125 | HSP90AB1 HSP90AA1 | HSF1 activation |
| REAC:R-HSA-5637812 | 0.021546998337 | 0.125 | HSP90AA1 CDC37 | Signaling by EGFRvIII in Cancer |
| REAC:R-HSA-9665348 | 0.0254483747841 | 0.125 | HSP90AA1 CDC37 | Signaling by ERBB2 ECD mutants |
| REAC:R-HSA-3371568 | 0.0254483747841 | 0.125 | HSP90AB1 HSP90AA1 | Attenuation phase |
| KEGG:04062 | 0.0255380464101 | 0.1875 | IKBKB IKBKG CHUK | Chemokine signaling pathway |
| REAC:R-HSA-168176 | 0.0264444044876 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.0264444044876 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.0264444044876 | 0.1875 | IKBKB IKBKG CHUK | MyD88 cascade initiated on plasma membrane |
| KEGG:05164 | 0.028321014162 | 0.1875 | IKBKB IKBKG CHUK | Influenza A |
| REAC:R-HSA-975138 | 0.0284142336573 | 0.1875 | IKBKB IKBKG CHUK | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.029434109996 | 0.1875 | IKBKB IKBKG CHUK | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.029434109996 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-1236974 | 0.029434109996 | 0.1875 | IKBKB IKBKG CHUK | ER-Phagosome pathway |
| KEGG:05161 | 0.0306826422625 | 0.1875 | IKBKB IKBKG CHUK | Hepatitis B |
| KEGG:04150 | 0.0306826422625 | 0.1875 | IKBKB STK11 CHUK | mTOR signaling pathway |
| WP:WP3929 | 0.0319074548735 | 0.1875 | IKBKB IKBKG CHUK | Chemokine signaling pathway |
| WP:WP2380 | 0.03348485935 | 0.1875 | IKBKB IKBKG CHUK | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP4630 | 0.03348485935 | 0.1875 | IKBKB IKBKG CHUK | Measles virus infection |
| REAC:R-HSA-202424 | 0.0337525088707 | 0.1875 | IKBKB IKBKG CHUK | Downstream TCR signaling |
| REAC:R-HSA-168138 | 0.0337525088707 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-399954 | 0.0342136955194 | 0.125 | HSP90AB1 HSP90AA1 | Sema3A PAK dependent Axon repulsion |
| REAC:R-HSA-9665686 | 0.0342136955194 | 0.125 | HSP90AA1 CDC37 | Signaling by ERBB2 TMD/JMD mutants |
| REAC:R-HSA-168164 | 0.0360585105265 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.0384650037198 | 0.1875 | IKBKB IKBKG CHUK | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.0384650037198 | 0.1875 | IKBKB IKBKG CHUK | MyD88-independent TLR4 cascade |
| REAC:R-HSA-1236382 | 0.0390764015632 | 0.125 | HSP90AA1 CDC37 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| REAC:R-HSA-5637815 | 0.0390764015632 | 0.125 | HSP90AA1 CDC37 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| REAC:R-HSA-168188 | 0.0409739415062 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.0409739415062 | 0.1875 | IKBKB IKBKG CHUK | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| KEGG:05130 | 0.0421251287894 | 0.1875 | IKBKB IKBKG CHUK | Pathogenic Escherichia coli infection |
| REAC:R-HSA-983705 | 0.0422674342942 | 0.1875 | IKBKB IKBKG CHUK | Signaling by the B Cell Receptor (BCR) |
| REAC:R-HSA-181438 | 0.0435872653979 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.0435872653979 | 0.1875 | IKBKB IKBKG CHUK | Toll Like Receptor TLR1:TLR2 Cascade |
| KEGG:05167 | 0.044390366553 | 0.1875 | IKBKB IKBKG CHUK | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-1236975 | 0.0449336757093 | 0.1875 | IKBKB IKBKG CHUK | Antigen processing-Cross presentation |
| WP:WP4666 | 0.0459545158339 | 0.1875 | IKBKB IKBKG CHUK | Hepatitis B infection |
| REAC:R-HSA-9020702 | 0.0463069054035 | 0.1875 | IKBKB IKBKG CHUK | Interleukin-1 signaling |
| REAC:R-HSA-9664565 | 0.0497588156052 | 0.125 | HSP90AA1 CDC37 | Signaling by ERBB2 KD Mutants |
| CORUM:5716 | 0.0497620750785 | 0.0625 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
| CORUM:2123 | 0.0497620750785 | 0.0625 | IKBKG | IKBKG homodimer complex |
| CORUM:5730 | 0.0497620750785 | 0.0625 | IKBKG | IKBKG homotrimer complex |
| CORUM:5827 | 0.0497620750785 | 0.0625 | IKBKG | IKBKG homotetramer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| IKBKG | IKBKB | 1.0 | 0.29 |
| HSP90AB1 | HSP90AA1 | 1.0 | 0.954 |
| CHUK | IKBKG | 0.999 | 0.176 |
| CDC37L1 | STK35 | 0.999 | 0.056 |
| CHUK | IKBKB | 0.998 | 0.07 |
| CDC37 | HSP90AA1 | 0.998 | 0.667333333333 |
| CDC37 | CHUK | 0.998 | 0.25 |
| CDC37 | IKBKB | 0.997 | 0.21 |
| CDC37 | STK35 | 0.997 | 0.108 |
| CDK11A | FKBP5 | 0.996 | |
| CDC37 | HSP90AB1 | 0.996 | 0.502 |
| EDRF1 | HSP90AB1 | 0.995 | 0.32305 |
| CDK11A | CDC37 | 0.994 | |
| HSP90AA1 | STK35 | 0.994 | 0.334152808277 |
| HSP90AB1 | STK35 | 0.993 | 0.25618165364 |
| FKBP5 | CDK15 | 0.993 | |
| CDK11A | HSP90AA1 | 0.993 | |
| CDK11A | HSP90AB1 | 0.992 | |
| CDC37 | IKBKG | 0.991 | 0.22 |
| CDC37 | STK11 | 0.991 | 0.139 |
| IKBKG | HSP90AA1 | 0.988 | 0.314 |
| CDC37L1 | HSP90AB1 | 0.986 | 0.351110091582 |
| TSSK6 | CDC37 | 0.986 | |
| STK11 | HSP90AB1 | 0.985 | 0.259625454545 |
| FKBP5 | HSP90AA1 | 0.984 | 0.346 |
| EDRF1 | HSP90AA1 | 0.983 | 0.474 |
| TSSK6 | FKBP5 | 0.983 | |
| TSSK6 | HSP90AA1 | 0.98 | |
| FKBP5 | HSP90AB1 | 0.978 | 0.367396470588 |
| TSSK6 | HSP90AB1 | 0.978 | |
| IKBKG | HSP90AB1 | 0.976 | 0.316097846684 |
| FKBP5 | CDC37 | 0.975 | 0.16 |
| FKBP5 | STK11 | 0.974 | 0.236 |
| STK11 | HSP90AA1 | 0.971 | 0.422591988764 |
| FKBP5 | IKBKB | 0.969 | 0.16 |
| MAP3K14 | IKBKG | 0.969 | |
| CDC37L1 | HSP90AA1 | 0.966 | 0.479316479401 |
| HSP90AB1 | UNC45B | 0.963 | 0.144 |
| MAP3K14 | IKBKB | 0.961 | |
| FKBP5 | CHUK | 0.958 | 0.126 |
| CDC37 | CDK15 | 0.957 | |
| A6NIL8 | CDC37 | 0.952 | |
| HSP90AA1 | UNC45B | 0.952 | 0.207431818182 |
| FKBP5 | IKBKG | 0.914 | 0.118 |
| CHUK | MAP3K14 | 0.901 | |
| A6NIL8 | CDK15 | 0.871 | |
| A6NIL8 | CHUK | 0.843 | |
| IKBKB | HSP90AA1 | 0.838 | 0.617333333333 |
| CHUK | HSP90AB1 | 0.784 | 0.4015 |
| A6NIL8 | IKBKB | 0.762 | |
| A6NIL8 | STK35 | 0.745 | |
| A6NIL8 | HSP90AB1 | 0.712 | |
| A6NIL8 | HSP90AA1 | 0.712 | |
| IKBKB | HSP90AB1 | 0.712 | 0.47 |
| A6NIL8 | IKBKG | 0.709 | |
| A6NIL8 | STK11 | 0.703 | |
| CDC37L1 | EDRF1 | 0.667 | 0.082 |
| FKBP5 | A6NIL8 | 0.664 | |
| CHUK | HSP90AA1 | 0.648 | 0.28219047619 |
| CHUK | CDC37L1 | 0.634 | 0.096 |
| CDC37 | CDC37L1 | 0.611 | 0.226 |
| CDK15 | HSP90AA1 | 0.583 | |
| IKBKG | EDRF1 | 0.573 | 0.092 |
| CDC37 | MAP3K14 | 0.551 | |
| CDK11A | CHUK | 0.512 | |
| CDK15 | HSP90AB1 | 0.504 | |
| CDK11A | IKBKG | 0.464 | |
| STK11 | STK35 | 0.405 | 0.08 |
| IKBKB | STK35 | 0.401 | 0.146 |
| STK11 | IKBKB | 0.356 | 0.206 |
| MAP3K14 | HSP90AB1 | 0.331 | |
| CDK11A | STK35 | 0.295 | |
| IKBKG | CDC37L1 | 0.249 | 0.138 |
| FKBP5 | STK35 | 0.249 | 0.088 |
| CDK11A | IKBKB | 0.227 | |
| IKBKG | STK35 | 0.22 | 0.08 |
| CDK11A | STK11 | 0.22 | |
| CHUK | EDRF1 | 0.213 | 0.078 |
| CHUK | STK35 | 0.188 | 0.12 |
| A6NIL8 | CDC37L1 | 0.188 | |
| STK11 | IKBKG | 0.157 | 0.164 |
| STK11 | CHUK | 0.147 | 0.18 |
| CDK11A | A6NIL8 | 0.13 | |
| MAP3K14 | HSP90AA1 | 0.118 | |
| FKBP5 | CDC37L1 | 0.093 | 0.082 |
| FKBP5 | EDRF1 | 0.025 | 0.078 |
| EDRF1 | STK35 | 0.023 | 0.09 |
| IKBKB | EDRF1 | 0.019 | 0.07 |
| A6NIL8 | EDRF1 | 0.013 | |
| FKBP5 | UNC45B | 0.01 | 0.044 |
| CDK11A | EDRF1 | 0.006 | |
| CDC37 | EDRF1 | 0.006 | 0.118 |
Related Complexes