hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10597.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CEP97 | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | 5 | UniProt NCBI |
| CEP290 | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | 5 | UniProt NCBI |
| CCP110 | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | 5 | UniProt NCBI |
| IQCB1 | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | 5 | UniProt NCBI |
| PHLDB3 | Pleckstrin homology-like domain family B member 3 | 3 | UniProt NCBI |
| KIF24 | Kinesin-like protein KIF24 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5620912 | 1.02710475482e-08 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | Anchoring of the basal body to the plasma membrane |
| REAC:R-HSA-5617833 | 3.74471976961e-07 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | Cilium Assembly |
| REAC:R-HSA-1852241 | 2.47115045635e-06 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | Organelle biogenesis and maintenance |
| CORUM:6594 | 1.70876175213e-05 | 0.333333333333 | CEP290 CCP110 | CCP110-CEP290 complex |
| CORUM:6597 | 1.70876175213e-05 | 0.333333333333 | IQCB1 CEP290 | CEP290-IQCB1 complex |
| WP:WP4656 | 0.0001559950529 | 0.5 | CCP110 CEP97 CEP290 | Joubert syndrome |
| GO:0060271 | 0.000659970192201 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | cilium assembly |
| GO:0044782 | 0.000939927808533 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | cilium organization |
| GO:1902018 | 0.00156505859778 | 0.5 | KIF24 CEP97 CCP110 | negative regulation of cilium assembly |
| GO:0005814 | 0.00193885768314 | 0.666666666667 | KIF24 CCP110 CEP97 CEP290 | centriole |
| WP:WP4352 | 0.00400681842466 | 0.5 | IQCB1 CEP97 CEP290 | Ciliary landscape |
| GO:0120031 | 0.00450571144333 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | plasma membrane bounded cell projection assembly |
| GO:0030031 | 0.00509483152423 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | cell projection assembly |
| GO:0120033 | 0.00777254411354 | 0.5 | KIF24 CEP97 CCP110 | negative regulation of plasma membrane bounded cell projection assembly |
| REAC:R-HSA-9013424 | 0.0152705482636 | 0.333333333333 | CEP97 CCP110 | RHOV GTPase cycle |
| GO:1902116 | 0.0161301339283 | 0.5 | KIF24 CEP97 CCP110 | negative regulation of organelle assembly |
| GO:0005813 | 0.0200389703503 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | centrosome |
| WP:WP5234 | 0.0283311425678 | 0.333333333333 | IQCB1 CEP290 | Bardet Biedl syndrome |
| GO:0005815 | 0.0465849513213 | 0.833333333333 | IQCB1 KIF24 CCP110 CEP97 CEP290 | microtubule organizing center |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CCP110 | CEP97 | 0.996 | 0.234602739726 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM gupta () boldt_WMM |
| CCP110 | IQCB1 | 0.995 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CCP110 | CEP290 | 0.993 | 0.189529204785 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt hein () gupta_WMM boldt_WMM |
| KIF24 | CEP97 | 0.992 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () boldt_WMM | |
| IQCB1 | CEP97 | 0.99 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| IQCB1 | CEP290 | 0.987 | 0.228 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt hein () gupta_WMM boldt_WMM |
| CCP110 | PHLDB3 | 0.961 | 0.18 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CEP290 | CEP97 | 0.96 | 0.172 | hein_WMM bioplex_WMM bioplex3_WMM gupta () hein () gupta_WMM boldt_WMM |
| CCP110 | KIF24 | 0.921 | hein_WMM bioplex3_HEK293 bioplex3_WMM boldt_WMM WMM_only | |
| PHLDB3 | IQCB1 | 0.36 | 0.13 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| PHLDB3 | CEP97 | 0.121 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only |
| PHLDB3 | CEP290 | 0.049 | 0.489113636364 | bioplex3_WMM WMM_only |
Related Complexes