hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10598.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UFD1 | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | 5 | UniProt NCBI |
| DEGS1 | Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-) | 5 | UniProt NCBI |
| NPLOC4 | Nuclear protein localization protein 4 homolog (Protein NPL4) | 5 | UniProt NCBI |
| VCP | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | 5 | UniProt NCBI |
| VCPKMT | Protein N-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-110320 | 3.01907146066e-06 | 0.6 | VCP UFD1 NPLOC4 | Translesion Synthesis by POLH |
| REAC:R-HSA-110313 | 2.62324018845e-05 | 0.6 | VCP UFD1 NPLOC4 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| CORUM:5685 | 4.09448956317e-05 | 0.4 | VCP UFD1 | Membrane protein complex (VCP, UFD1L, SEC61B) |
| REAC:R-HSA-73893 | 5.03751582702e-05 | 0.6 | VCP UFD1 NPLOC4 | DNA Damage Bypass |
| GO:0034098 | 5.37995977657e-05 | 0.6 | VCP UFD1 NPLOC4 | VCP-NPL4-UFD1 AAA ATPase complex |
| CORUM:6280 | 8.18785830799e-05 | 0.4 | UFD1 NPLOC4 | NUB1L-UFD1-NPL4-NEDD8 complex |
| REAC:R-HSA-9755511 | 0.000562430441913 | 0.6 | VCP UFD1 NPLOC4 | KEAP1-NFE2L2 pathway |
| KEGG:04141 | 0.000570106569601 | 0.6 | VCP UFD1 NPLOC4 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-8876725 | 0.0018206657072 | 0.4 | VCP VCPKMT | Protein methylation |
| GO:1903513 | 0.00280458876292 | 0.6 | VCP UFD1 NPLOC4 | endoplasmic reticulum to cytosol transport |
| GO:0030970 | 0.00280458876292 | 0.6 | VCP UFD1 NPLOC4 | retrograde protein transport, ER to cytosol |
| REAC:R-HSA-9711123 | 0.00307789040511 | 0.6 | VCP UFD1 NPLOC4 | Cellular response to chemical stress |
| GO:0036501 | 0.00468200720083 | 0.4 | UFD1 NPLOC4 | UFD1-NPL4 complex |
| REAC:R-HSA-8951664 | 0.00571342832938 | 0.6 | VCP UFD1 NPLOC4 | Neddylation |
| GO:0032527 | 0.0126766174236 | 0.6 | VCP UFD1 NPLOC4 | protein exit from endoplasmic reticulum |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | VCP UFD1 NPLOC4 | DNA Repair |
| GO:0036503 | 0.016548216138 | 0.6 | VCP UFD1 NPLOC4 | ERAD pathway |
| REAC:R-HSA-597592 | 0.0380600523345 | 0.8 | VCP VCPKMT UFD1 NPLOC4 | Post-translational protein modification |
| GO:0039536 | 0.0468008499735 | 0.4 | UFD1 NPLOC4 | negative regulation of RIG-I signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UFD1 | NPLOC4 | 1.0 | 0.738 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| VCPKMT | VCP | 0.998 | 0.242 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UFD1 | VCP | 0.992 | 0.582 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NPLOC4 | VCP | 0.976 | 0.712 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| DEGS1 | NPLOC4 | 0.965 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DEGS1 | UFD1 | 0.936 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DEGS1 | VCP | 0.269 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| UFD1 | VCPKMT | 0.055 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
| NPLOC4 | VCPKMT | 0.045 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes