hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10599.1
Complex Portal: CPX-18339
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC35B3 | Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (3'-phosphoadenosine 5'-phosphosulfate transporter) (PAPS transporter 2) (Solute carrier family 35 member B3) | 5 | UniProt NCBI |
| GTPBP6 | Putative GTP-binding protein 6 (Pseudoautosomal GTP-binding protein-like) | 3 | UniProt NCBI |
| SPRR1A | Cornifin-A (19 kDa pancornulin) (SPRK) (Small proline-rich protein IA) (SPR-IA) | 5 | UniProt NCBI |
| SPRR1B | Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB) | 5 | UniProt NCBI |
| TRMT10C | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | 5 | UniProt NCBI |
| MRM1 | rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase) | 5 | UniProt NCBI |
| DECR1 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1) | 5 | UniProt NCBI |
| NUDT3 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) | 5 | UniProt NCBI |
| ELAC2 | Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) | 5 | UniProt NCBI |
| HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8868766 | 3.29426179613e-09 | 0.444444444444 | MRM1 TRMT10C HSD17B10 ELAC2 | rRNA processing in the mitochondrion |
| REAC:R-HSA-6785470 | 3.82422324355e-07 | 0.333333333333 | TRMT10C HSD17B10 ELAC2 | tRNA processing in the mitochondrion |
| CORUM:7429 | 2.73623797451e-05 | 0.222222222222 | TRMT10C HSD17B10 | HSD17B10-TRMT10C complex |
| GO:1990180 | 3.22863876272e-05 | 0.333333333333 | TRMT10C HSD17B10 ELAC2 | mitochondrial tRNA 3'-end processing |
| CORUM:7428 | 8.20609246787e-05 | 0.222222222222 | TRMT10C HSD17B10 | mtRNase P |
| GO:0000965 | 0.000161332517231 | 0.333333333333 | TRMT10C HSD17B10 ELAC2 | mitochondrial RNA 3'-end processing |
| GO:0042780 | 0.000161332517231 | 0.333333333333 | TRMT10C HSD17B10 ELAC2 | tRNA 3'-end processing |
| REAC:R-HSA-72312 | 0.000963041221728 | 0.444444444444 | MRM1 TRMT10C HSD17B10 ELAC2 | rRNA processing |
| WP:WP5241 | 0.00110480463477 | 0.222222222222 | DECR1 HSD17B10 | Mitochondrial beta oxidation |
| REAC:R-HSA-6787450 | 0.00223242997382 | 0.222222222222 | TRMT10C HSD17B10 | tRNA modification in the mitochondrion |
| GO:0090646 | 0.00230208510773 | 0.333333333333 | TRMT10C HSD17B10 ELAC2 | mitochondrial tRNA processing |
| REAC:R-HSA-72306 | 0.00582679710393 | 0.333333333333 | TRMT10C HSD17B10 ELAC2 | tRNA processing |
| GO:0000963 | 0.00915637133828 | 0.333333333333 | TRMT10C HSD17B10 ELAC2 | mitochondrial RNA processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TRMT10C | ELAC2 | 0.999 | 0.16 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| TRMT10C | HSD17B10 | 0.998 | 0.182 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| DECR1 | MRM1 | 0.995 | 0.302 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPRR1A | NUDT3 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GTPBP6 | ELAC2 | 0.991 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| HSD17B10 | MRM1 | 0.985 | 0.074 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPRR1A | MRM1 | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SPRR1B | MRM1 | 0.98 | 0.148 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GTPBP6 | TRMT10C | 0.973 | 0.248 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| TRMT10C | MRM1 | 0.971 | 0.488 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DECR1 | ELAC2 | 0.971 | 0.138 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| NUDT3 | SPRR1B | 0.97 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GTPBP6 | MRM1 | 0.963 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TRMT10C | DECR1 | 0.962 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SLC35B3 | TRMT10C | 0.958 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELAC2 | HSD17B10 | 0.957 | 0.078 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| GTPBP6 | DECR1 | 0.945 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| GTPBP6 | HSD17B10 | 0.941 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| DECR1 | HSD17B10 | 0.884 | 0.352 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only | |
| SPRR1A | SPRR1B | 0.826 | bioplex3_WMM WMM_only boldt_WMM | ||
| ELAC2 | MRM1 | 0.55 | 0.164 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPRR1A | DECR1 | 0.019 | bioplex3_WMM WMM_only | ||
| DECR1 | SPRR1B | 0.012 | 0.12 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| NUDT3 | DECR1 | 0.009 | 0.028 | bioplex3_HCT116 WMM_only | |
| SPRR1A | ELAC2 | 0.009 | bioplex3_WMM WMM_only | ||
| SPRR1A | TRMT10C | 0.009 | bioplex3_WMM WMM_only | ||
| SPRR1A | HSD17B10 | 0.008 | bioplex3_WMM WMM_only boldt_WMM | ||
| ELAC2 | SPRR1B | 0.008 | 0.064 | bioplex3_WMM WMM_only | |
| TRMT10C | SPRR1B | 0.007 | 0.046 | bioplex3_WMM WMM_only | |
| SLC35B3 | HSD17B10 | 0.001 | 0.098 | bioplex3_HEK293 bioplex () bioplex3_HCT116 gupta_WMM | |
| HSD17B10 | SPRR1B | 0.001 | 0.06 | bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
Related Complexes