hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10600.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATF4 | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) | 5 | UniProt NCBI |
| CEBPG | CCAAT/enhancer-binding protein gamma (C/EBP gamma) | 5 | UniProt NCBI |
| CEBPA | CCAAT/enhancer-binding protein alpha (C/EBP alpha) | 5 | UniProt NCBI |
| DDIT3 | DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) | 5 | UniProt NCBI |
| CEBPB | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4211 | 7.89378930275e-12 | 1.0 | CEBPA CEBPB CEBPG DDIT3 | Transcriptional cascade regulating adipogenesis |
| GO:0036488 | 3.84480164306e-07 | 0.75 | CEBPA CEBPB DDIT3 | CHOP-C/EBP complex |
| WP:WP2895 | 4.64441977488e-07 | 0.75 | CEBPA CEBPG CEBPB | Differentiation of white and brown adipocyte |
| REAC:R-HSA-9648895 | 5.10480886775e-07 | 0.75 | DDIT3 CEBPG CEBPB | Response of EIF2AK1 (HRI) to heme deficiency |
| WP:WP4149 | 8.03005285051e-07 | 0.75 | CEBPA CEBPB DDIT3 | White fat cell differentiation |
| GO:0140467 | 1.54994552959e-06 | 1.0 | CEBPA CEBPB CEBPG DDIT3 | integrated stress response signaling |
| REAC:R-HSA-380994 | 3.64404491129e-06 | 0.75 | DDIT3 CEBPG CEBPB | ATF4 activates genes in response to endoplasmic reticulum stress |
| REAC:R-HSA-381042 | 6.29837429836e-06 | 0.75 | DDIT3 CEBPG CEBPB | PERK regulates gene expression |
| WP:WP236 | 6.90056161201e-05 | 0.75 | CEBPA CEBPB DDIT3 | Adipogenesis |
| REAC:R-HSA-381119 | 0.000133147800117 | 0.75 | DDIT3 CEBPG CEBPB | Unfolded Protein Response (UPR) |
| KEGG:05202 | 0.000207322743729 | 0.75 | CEBPA CEBPB DDIT3 | Transcriptional misregulation in cancer |
| REAC:R-HSA-9633012 | 0.000225769742075 | 0.75 | DDIT3 CEBPG CEBPB | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| WP:WP3599 | 0.000436026474737 | 0.5 | CEBPA CEBPB | Transcription factor regulation in adipogenesis |
| REAC:R-HSA-9711097 | 0.00081494341463 | 0.75 | DDIT3 CEBPG CEBPB | Cellular response to starvation |
| WP:WP2817 | 0.000828175715845 | 0.5 | CEBPA CEBPB | Mammary gland development pathway Pregnancy and lactation Stage 3 of 4 |
| WP:WP4844 | 0.00110807642161 | 0.5 | CEBPA CEBPB | Influence of laminopathies on Wnt signaling |
| GO:0090575 | 0.00188011523943 | 1.0 | CEBPA CEBPB CEBPG DDIT3 | RNA polymerase II transcription regulator complex |
| WP:WP395 | 0.0027493593259 | 0.5 | CEBPA CEBPB | IL 4 signaling pathway |
| WP:WP4879 | 0.0027493593259 | 0.5 | CEBPA CEBPB | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| GO:1990647 | 0.0028092043205 | 0.5 | CEBPA CEBPB | C/EBP complex |
| GO:0001889 | 0.00298219742351 | 0.75 | CEBPA CEBPG CEBPB | liver development |
| GO:0061008 | 0.00323764786551 | 0.75 | CEBPA CEBPG CEBPB | hepaticobiliary system development |
| GO:0005667 | 0.0179080675177 | 1.0 | CEBPA CEBPB CEBPG DDIT3 | transcription regulator complex |
| WP:WP4396 | 0.023499356813 | 0.5 | CEBPA DDIT3 | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.0237566589162 | 0.5 | CEBPA DDIT3 | Non-alcoholic fatty liver disease |
| CORUM:746 | 0.0249718442456 | 0.25 | CEBPA | C/EBPalpha-HNF6 complex |
| REAC:R-HSA-9616222 | 0.0253175164514 | 0.5 | CEBPA CEBPB | Transcriptional regulation of granulopoiesis |
| KEGG:05152 | 0.02620193588 | 0.5 | CEBPB CEBPG | Tuberculosis |
| REAC:R-HSA-381340 | 0.0282617295192 | 0.5 | CEBPA CEBPB | Transcriptional regulation of white adipocyte differentiation |
| CORUM:5383 | 0.049938562206 | 0.25 | DDIT3 | TRIB3-DDIT3 complex |
| CORUM:6068 | 0.049938562206 | 0.25 | CEBPB | ESR1-CEBPB complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DDIT3 | CEBPG | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CEBPA | DDIT3 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CEBPB | DDIT3 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF4 | CEBPG | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF4 | CEBPB | 0.955 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CEBPA | CEBPB | 0.415 | bioplex3_WMM WMM_only | |
| CEBPA | CEBPG | 0.278 | bioplex3_WMM WMM_only | |
| CEBPB | CEBPG | 0.113 | bioplex3_WMM WMM_only |
Related Complexes