hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10604.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SKA2 | Spindle and kinetochore-associated protein 2 (Protein FAM33A) | 5 | UniProt NCBI |
| SKA3 | Spindle and kinetochore-associated protein 3 | 5 | UniProt NCBI |
| IER5L | Immediate early response gene 5-like protein | 2 | UniProt NCBI |
| IER5 | Immediate early response gene 5 protein | 5 | UniProt NCBI |
| ATOSB | Atos homolog protein B | 5 | UniProt NCBI |
| PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) | 5 | UniProt NCBI |
| PI3 | Elafin (Elastase-specific inhibitor) (ESI) (Peptidase inhibitor 3) (PI-3) (Protease inhibitor WAP3) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14) | 5 | UniProt NCBI |
| SKA1 | Spindle and kinetochore-associated protein 1 | 5 | UniProt NCBI |
| PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55-gamma) (PP2A subunit B isoform PR55-gamma) (PP2A subunit B isoform R2-gamma) (PP2A subunit B isoform gamma) | 4 | UniProt NCBI |
| SERTAD2 | SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000159 | 0.00655807506899 | 0.333333333333 | IER5 PPP2R2B PPP2R2C | protein phosphatase type 2A complex |
| GO:0000940 | 0.00915637133828 | 0.333333333333 | SKA1 SKA2 SKA3 | outer kinetochore |
| GO:0051315 | 0.0162365457737 | 0.333333333333 | SKA1 SKA2 SKA3 | attachment of mitotic spindle microtubules to kinetochore |
| WP:WP500 | 0.0202568688475 | 0.222222222222 | PPP2R2C PPP2R2B | Glycogen synthesis and degradation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SKA1 | SKA2 | 1.0 | 0.302 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| SKA3 | SKA2 | 1.0 | 0.446 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| SKA1 | SKA3 | 1.0 | 0.636 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| PPP2R2B | ATOSB | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP2R2C | SKA2 | 0.998 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| IER5 | PPP2R2B | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SERTAD2 | PPP2R2B | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP2R2C | PPP2R2B | 0.996 | 0.706 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SKA2 | PPP2R2B | 0.995 | 0.094 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| SKA3 | PPP2R2B | 0.993 | 0.074 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| IER5 | PPP2R2C | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PPP2R2C | SERTAD2 | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SKA3 | PPP2R2C | 0.984 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| IER5L | PPP2R2B | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PI3 | PPP2R2B | 0.968 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SKA1 | PPP2R2B | 0.956 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| SKA2 | ATOSB | 0.904 | bioplex3_WMM WMM_only | |
| SERTAD2 | ATOSB | 0.902 | bioplex3_WMM WMM_only | |
| IER5L | ATOSB | 0.902 | bioplex3_WMM WMM_only | |
| IER5 | ATOSB | 0.902 | bioplex3_WMM WMM_only | |
| SKA3 | ATOSB | 0.892 | bioplex3_WMM WMM_only | |
| SKA1 | ATOSB | 0.858 | bioplex3_WMM WMM_only | |
| SKA3 | IER5 | 0.831 | bioplex_WMM bioplex3_WMM WMM_only | |
| SKA1 | PPP2R2C | 0.813 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| IER5 | SKA2 | 0.771 | bioplex_WMM bioplex3_WMM WMM_only | |
| IER5 | SERTAD2 | 0.737 | bioplex3_WMM WMM_only | |
| SKA1 | IER5 | 0.698 | bioplex_WMM bioplex3_WMM WMM_only | |
| IER5 | IER5L | 0.455 | bioplex3_WMM WMM_only | |
| SERTAD2 | IER5L | 0.455 | bioplex3_WMM WMM_only | |
| SKA3 | SERTAD2 | 0.431 | bioplex3_WMM WMM_only | |
| SKA3 | IER5L | 0.407 | bioplex3_WMM WMM_only | |
| SKA2 | IER5L | 0.401 | bioplex3_WMM WMM_only | |
| SERTAD2 | SKA2 | 0.389 | bioplex3_WMM WMM_only | |
| SKA1 | SERTAD2 | 0.367 | bioplex3_WMM WMM_only | |
| SKA1 | IER5L | 0.356 | bioplex3_WMM WMM_only | |
| PPP2R2C | IER5L | 0.288 | bioplex3_WMM WMM_only | |
| IER5 | PI3 | 0.274 | bioplex3_WMM WMM_only | |
| SERTAD2 | PI3 | 0.274 | bioplex3_WMM WMM_only | |
| PI3 | ATOSB | 0.214 | bioplex3_WMM WMM_only | |
| PI3 | IER5L | 0.214 | bioplex3_WMM WMM_only | |
| PPP2R2C | ATOSB | 0.146 | bioplex3_WMM WMM_only | |
| PPP2R2C | PI3 | 0.078 | bioplex3_WMM WMM_only | |
| PI3 | SKA2 | 0.078 | bioplex3_WMM WMM_only | |
| SKA3 | PI3 | 0.078 | bioplex3_WMM WMM_only | |
| SKA1 | PI3 | 0.076 | bioplex3_WMM WMM_only |
Related Complexes