hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10605.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCDC40 | Coiled-coil domain-containing protein 40 | 5 | UniProt NCBI |
| PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) | 5 | UniProt NCBI |
| PSMC3 | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | 5 | UniProt NCBI |
| UNC13B | Protein unc-13 homolog B (Munc13-2) (munc13) | 5 | UniProt NCBI |
| TRAF5 | TNF receptor-associated factor 5 (RING finger protein 84) | 5 | UniProt NCBI |
| STKLD1 | Serine/threonine kinase-like domain-containing protein STKLD1 (Serine/threonine kinase-like domain-containing protein 1) (Sugen kinase 071) | 4 | UniProt NCBI |
| ANKRD26 | Ankyrin repeat domain-containing protein 26 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:32 | 0.0038840581796 | 0.285714285714 | PSMD9 PSMC3 | PA700 complex |
| KEGG:03050 | 0.0100614067411 | 0.285714285714 | PSMD9 PSMC3 | Proteasome |
| CORUM:193 | 0.0107616123041 | 0.285714285714 | PSMD9 PSMC3 | PA700-20S-PA28 complex |
| WP:WP183 | 0.0321598473831 | 0.285714285714 | PSMD9 PSMC3 | Proteasome degradation |
| WP:WP2359 | 0.039968890476 | 0.285714285714 | PSMD9 PSMC3 | Parkin ubiquitin proteasomal system pathway |
| REAC:R-HSA-1236978 | 0.0407752524289 | 0.285714285714 | PSMD9 PSMC3 | Cross-presentation of soluble exogenous antigens (endosomes) |
| REAC:R-HSA-211733 | 0.0443383907933 | 0.285714285714 | PSMD9 PSMC3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
| REAC:R-HSA-350562 | 0.0461752771557 | 0.285714285714 | PSMD9 PSMC3 | Regulation of ornithine decarboxylase (ODC) |
| REAC:R-HSA-75815 | 0.0480490075434 | 0.285714285714 | PSMD9 PSMC3 | Ubiquitin-dependent degradation of Cyclin D |
| REAC:R-HSA-180534 | 0.0480490075434 | 0.285714285714 | PSMD9 PSMC3 | Vpu mediated degradation of CD4 |
| REAC:R-HSA-69610 | 0.0480490075434 | 0.285714285714 | PSMD9 PSMC3 | p53-Independent DNA Damage Response |
| REAC:R-HSA-69613 | 0.0480490075434 | 0.285714285714 | PSMD9 PSMC3 | p53-Independent G1/S DNA damage checkpoint |
| REAC:R-HSA-349425 | 0.0480490075434 | 0.285714285714 | PSMD9 PSMC3 | Autodegradation of the E3 ubiquitin ligase COP1 |
| REAC:R-HSA-69601 | 0.0480490075434 | 0.285714285714 | PSMD9 PSMC3 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| REAC:R-HSA-9604323 | 0.0499595563988 | 0.285714285714 | PSMD9 PSMC3 | Negative regulation of NOTCH4 signaling |
| REAC:R-HSA-169911 | 0.0499595563988 | 0.285714285714 | PSMD9 PSMC3 | Regulation of Apoptosis |
| REAC:R-HSA-180585 | 0.0499595563988 | 0.285714285714 | PSMD9 PSMC3 | Vif-mediated degradation of APOBEC3G |
| REAC:R-HSA-450408 | 0.0499595563988 | 0.285714285714 | PSMD9 PSMC3 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| REAC:R-HSA-9762114 | 0.0499595563988 | 0.285714285714 | PSMD9 PSMC3 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PSMD9 | PSMC3 | 1.0 | 0.562 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| STKLD1 | PSMC3 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TRAF5 | CCDC40 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PSMD9 | CCDC40 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CCDC40 | PSMC3 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| UNC13B | CCDC40 | 0.962 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ANKRD26 | CCDC40 | 0.961 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PSMD9 | STKLD1 | 0.314 | bioplex_WMM bioplex3_WMM WMM_only | |
| TRAF5 | UNC13B | 0.189 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
| ANKRD26 | UNC13B | 0.185 | 0.278 | bioplex_WMM bioplex3_WMM WMM_only |
| UNC13B | PSMC3 | 0.109 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
| TRAF5 | ANKRD26 | 0.102 | 0.122 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PSMD9 | TRAF5 | 0.102 | 0.196 | bioplex_WMM bioplex3_WMM WMM_only |
| PSMD9 | ANKRD26 | 0.053 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only |
| PSMD9 | UNC13B | 0.044 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only |
| ANKRD26 | PSMC3 | 0.024 | 0.162 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| TRAF5 | PSMC3 | 0.01 | 0.32 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes