hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10606.1
Complex Portal: CPX-25001
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STXBP2 | Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) | 5 | UniProt NCBI |
| STX19 | Syntaxin-19 | 5 | UniProt NCBI |
| STX11 | Syntaxin-11 | 5 | UniProt NCBI |
| PIR | Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase) | 5 | UniProt NCBI |
| WRNIP1 | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | 5 | UniProt NCBI |
| STXBP5L | Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) | 5 | UniProt NCBI |
| STXBP1 | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | 5 | UniProt NCBI |
| PDZRN3 | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000149 | 1.63146572742e-05 | 0.625 | STXBP2 STXBP5L STXBP1 STX19 STX11 | SNARE binding |
| GO:0048278 | 0.000576145671782 | 0.5 | STXBP2 STXBP1 STX19 STX11 | vesicle docking |
| GO:0140029 | 0.000576145671782 | 0.5 | STXBP2 STXBP1 STX19 STX11 | exocytic process |
| GO:0031629 | 0.00118146610329 | 0.375 | STX11 STX19 STXBP1 | synaptic vesicle fusion to presynaptic active zone membrane |
| GO:0099500 | 0.00118146610329 | 0.375 | STX11 STX19 STXBP1 | vesicle fusion to plasma membrane |
| HP:0011118 | 0.00135542525381 | 0.25 | STXBP2 STX11 | Abnormality of tumor necrosis factor secretion |
| GO:0140056 | 0.00147909060032 | 0.5 | STXBP2 STXBP1 STX19 STX11 | organelle localization by membrane tethering |
| GO:0006887 | 0.00223097220856 | 0.625 | STXBP2 STXBP5L STXBP1 STX19 STX11 | exocytosis |
| HP:0011113 | 0.00225842370351 | 0.25 | STXBP2 STX11 | Abnormality of cytokine secretion |
| GO:0022406 | 0.00245296942189 | 0.5 | STXBP2 STXBP1 STX19 STX11 | membrane docking |
| GO:0048499 | 0.00364711882004 | 0.375 | STX11 STX19 STXBP1 | synaptic vesicle membrane organization |
| GO:0007269 | 0.00366371076373 | 0.5 | STXBP2 STXBP1 STX19 STX11 | neurotransmitter secretion |
| GO:0099643 | 0.00366371076373 | 0.5 | STXBP2 STXBP1 STX19 STX11 | signal release from synapse |
| HP:0030783 | 0.00474009355523 | 0.25 | STXBP2 STX11 | Increased circulating interleukin 6 concentration |
| KEGG:04130 | 0.00598787744984 | 0.25 | STX11 STX19 | SNARE interactions in vesicular transport |
| GO:0006836 | 0.00964797417951 | 0.5 | STXBP2 STXBP1 STX19 STX11 | neurotransmitter transport |
| HP:0002958 | 0.0124009419501 | 0.25 | STXBP2 STX11 | Immune dysregulation |
| HP:0012177 | 0.0175771621337 | 0.25 | STXBP2 STX11 | Abnormal natural killer cell physiology |
| HP:0012178 | 0.0175771621337 | 0.25 | STXBP2 STX11 | Reduced natural killer cell activity |
| GO:0045055 | 0.0191211831796 | 0.5 | STXBP2 STXBP1 STX19 STX11 | regulated exocytosis |
| HP:0002611 | 0.0270195830756 | 0.25 | STXBP2 STX11 | Cholestatic liver disease |
| HP:0004386 | 0.0299676437717 | 0.375 | STXBP2 STXBP1 STX11 | Gastrointestinal inflammation |
| HP:0012156 | 0.0306138099712 | 0.25 | STXBP2 STX11 | Hemophagocytosis |
| HP:0040186 | 0.0344311064357 | 0.25 | STXBP2 STX11 | Maculopapular exanthema |
| HP:0030356 | 0.0344311064357 | 0.25 | STXBP2 STX11 | Increased circulating interferon-gamma concentration |
| HP:4000054 | 0.0384712883781 | 0.25 | STXBP2 STX11 | Exanthem |
| HP:0012229 | 0.0472195728067 | 0.25 | STXBP2 STX11 | CSF pleocytosis |
| HP:0030782 | 0.0472195728067 | 0.25 | STXBP2 STX11 | Abnormal circulating interleukin concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| STXBP2 | STX11 | 0.999 | 0.14 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| STX19 | STXBP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STXBP1 | STX11 | 0.999 | 0.074 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| STX19 | STXBP1 | 0.998 |
mutually_exclusive (P63027)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STXBP5L | STX19 | 0.995 |
mutually_exclusive (O00161)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PIR | STX11 | 0.987 | 0.028 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| STXBP2 | STXBP1 | 0.983 | 0.02 |
mutually_exclusive (O75558)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
| WRNIP1 | STX11 | 0.978 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PDZRN3 | STX11 | 0.971 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PIR | STXBP1 | 0.501 | 0.028 | bioplex3_WMM WMM_only | |
| PIR | STXBP2 | 0.217 | 0.06 | bioplex3_WMM WMM_only | |
| STXBP5L | STXBP2 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PDZRN3 | STXBP1 | 0.174 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| STXBP5L | STXBP1 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PDZRN3 | STXBP2 | 0.166 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| STXBP1 | WRNIP1 | 0.069 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIR | PDZRN3 | 0.028 | 0.054 | bioplex3_WMM WMM_only | |
| PIR | WRNIP1 | 0.018 | 0.012 | bioplex3_WMM WMM_only | |
| STXBP2 | WRNIP1 | 0.013 | 0.008 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | |
| PDZRN3 | WRNIP1 | 0.011 | 0.044 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes