hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10612.1

Complex Portal: CPX-25394

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
DCAF8L2	DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)	2	UniProt NCBI
DCAF16	DDB1- and CUL4-associated factor 16	4	UniProt NCBI
DCAF6	DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)	5	UniProt NCBI
RBX1	E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]	5	UniProt NCBI
DCAF8L1	DDB1- and CUL4-associated factor 8-like protein 1 (WD repeat-containing protein 42B)	2	UniProt NCBI
TENT5A	Terminal nucleotidyltransferase 5A (EC 2.7.7.19) (HBV X-transactivated gene 11 protein) (HBV XAg-transactivated protein 11)	5	UniProt NCBI
CRBN	Protein cereblon	5	UniProt NCBI
CUL4A	Cullin-4A (CUL-4A)	5	UniProt NCBI
CUL4B	Cullin-4B (CUL-4B)	5	UniProt NCBI
DCAF8	DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)	5	UniProt NCBI
DDB1	DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)	5	UniProt NCBI
BRWD3	Bromodomain and WD repeat-containing protein 3	5	UniProt NCBI
WDTC1	WD and tetratricopeptide repeats protein 1	5	UniProt NCBI
DDA1	DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0080008	2.87672294164e-26	0.857142857143	CUL4B WDTC1 DCAF8 DCAF8L1 RBX1 DCAF6 DCAF8L2 DDA1 DDB1 DCAF16 CRBN CUL4A	Cul4-RING E3 ubiquitin ligase complex
GO:0031461	1.71701943315e-17	0.857142857143	CUL4B WDTC1 DCAF8 DCAF8L1 RBX1 DCAF6 DCAF8L2 DDA1 DDB1 DCAF16 CRBN CUL4A	cullin-RING ubiquitin ligase complex
GO:0000151	7.79181425909e-15	0.857142857143	CUL4B WDTC1 DCAF8 DCAF8L1 RBX1 DCAF6 DCAF8L2 DDA1 DDB1 DCAF16 CRBN CUL4A	ubiquitin ligase complex
REAC:R-HSA-8951664	2.17804684337e-11	0.642857142857	WDTC1 RBX1 DCAF8 CUL4A DDB1 DCAF16 DDA1 CUL4B DCAF6	Neddylation
CORUM:6875	2.74936781213e-11	0.285714285714	RBX1 DDB1 CUL4A CRBN	CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase
CORUM:1162	1.3739312217e-10	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)
GO:1990234	1.93784889399e-09	0.857142857143	CUL4B WDTC1 DCAF8 DCAF8L1 RBX1 DCAF6 DCAF8L2 DDA1 DDB1 DCAF16 CRBN CUL4A	transferase complex
GO:0140535	3.85913838493e-09	0.857142857143	CUL4B WDTC1 DCAF8 DCAF8L1 RBX1 DCAF6 DCAF8L2 DDA1 DDB1 DCAF16 CRBN CUL4A	intracellular protein-containing complex
GO:0031464	3.59232088258e-08	0.357142857143	CUL4B RBX1 DDB1 CUL4A CRBN	Cul4A-RING E3 ubiquitin ligase complex
CORUM:2722	3.65216022462e-08	0.214285714286	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:391	3.65216022462e-08	0.214285714286	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:2172	1.4600392795e-07	0.214285714286	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)
CORUM:1214	3.64803730192e-07	0.214285714286	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
CORUM:1211	7.29195506708e-07	0.214285714286	RBX1 CUL4B DDB1	Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)
REAC:R-HSA-110314	3.99780189739e-06	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Recognition of DNA damage by PCNA-containing replication complex
GO:1902494	6.10364440658e-06	0.857142857143	CUL4B WDTC1 DCAF8 DCAF8L1 RBX1 DCAF6 DCAF8L2 DDA1 DDB1 DCAF16 CRBN CUL4A	catalytic complex
WP:WP4753	7.41667114027e-06	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Nucleotide excision repair
CORUM:728	7.99401369402e-06	0.214285714286	RBX1 CUL4A DDB1	CSA-POLIIa complex
CORUM:727	7.99401369402e-06	0.214285714286	RBX1 CUL4A DDB1	CSA complex
CORUM:726	7.99401369402e-06	0.214285714286	RBX1 CUL4A DDB1	DDB2 complex
REAC:R-HSA-5696394	1.07209019651e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	DNA Damage Recognition in GG-NER
KEGG:03420	1.20677180985e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Nucleotide excision repair
REAC:R-HSA-5696400	1.4684294661e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Dual Incision in GG-NER
REAC:R-HSA-5696395	1.62211121973e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Formation of Incision Complex in GG-NER
REAC:R-HSA-73893	2.57782160852e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	DNA Damage Bypass
REAC:R-HSA-6781823	3.90193902535e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Formation of TC-NER Pre-Incision Complex
WP:WP5114	6.43443583169e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Nucleotide excision repair in xeroderma pigmentosum
REAC:R-HSA-597592	7.95809590599e-05	0.642857142857	WDTC1 RBX1 DCAF8 CUL4A DDB1 DCAF16 DDA1 CUL4B DCAF6	Post-translational protein modification
REAC:R-HSA-6782210	8.53361515211e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	9.09752886562e-05	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Dual incision in TC-NER
CORUM:223	0.000133349500201	0.142857142857	RBX1 CUL4A	CAND1-CUL4A-RBX1 complex
CORUM:6553	0.000133349500201	0.142857142857	DDB1 CUL4B	CUL4B-DDB1-TLE3 complex
CORUM:6550	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4B-DDB1-TLE1 complex
CORUM:6495	0.000133349500201	0.142857142857	DDB1 CUL4B	CUL4B-DDB1-GRWD1 complex
CORUM:6494	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4A-DDB1-WDR61 complex
CORUM:6493	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4A-DDB1-WDR57 complex
CORUM:6492	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4A-DDB1-WDR5B complex
CORUM:6491	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4A-DDB1-RBBP5 complex
CORUM:6490	0.000133349500201	0.142857142857	DDB1 CUL4B	CUL4B-DDB1-WDR26 complex
CORUM:6489	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4A-DDB1-WDR5 complex
CORUM:6488	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4A-DDB1-EED complex
CORUM:6487	0.000133349500201	0.142857142857	DDB1 CUL4B	CUL4B-DDB1-TLE2 complex
CORUM:6486	0.000133349500201	0.142857142857	DDB1 CUL4A	CUL4A-DDB1-DTL complex
CORUM:224	0.000133349500201	0.142857142857	RBX1 CUL4B	CAND1-CUL4B-RBX1 complex
REAC:R-HSA-6781827	0.00019238872153	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
REAC:R-HSA-5696399	0.000260386491566	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Global Genome Nucleotide Excision Repair (GG-NER)
CORUM:6291	0.000266552996475	0.142857142857	DDB1 CUL4A	Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A)
GO:0031465	0.000349481973524	0.214285714286	RBX1 CUL4B DDB1	Cul4B-RING E3 ubiquitin ligase complex
KEGG:04120	0.000360797424151	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Ubiquitin mediated proteolysis
WP:WP4946	0.000372364210331	0.285714285714	RBX1 DDB1 CUL4A CUL4B	DNA repair pathways full network
CORUM:6482	0.000444011791638	0.142857142857	DDB1 CUL4B	CUL4B-DDB1-DTL-CSN complex
REAC:R-HSA-5696398	0.000749013011324	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Nucleotide Excision Repair
REAC:R-HSA-392499	0.00129289442112	0.642857142857	WDTC1 RBX1 DCAF8 CUL4A DDB1 DCAF16 DDA1 CUL4B DCAF6	Metabolism of proteins
KEGG:05170	0.00147970242596	0.285714285714	RBX1 DDB1 CUL4A CUL4B	Human immunodeficiency virus 1 infection
WP:WP4541	0.0110560849873	0.214285714286	RBX1 CUL4A DDB1	Hippo Merlin signaling dysregulation
CORUM:929	0.0245167293555	0.142857142857	DDB1 CUL4A	CEN complex
GO:0034644	0.0307912643026	0.285714285714	RBX1 DDB1 CUL4A CUL4B	cellular response to UV
REAC:R-HSA-73894	0.0448854345208	0.285714285714	RBX1 DDB1 CUL4A CUL4B	DNA Repair

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CUL4A	CUL4B	0.999	0.374
DDB1	DDA1	0.999	0.2	structurally_consistent (dimer)
WDTC1	CUL4A	0.999	0.084	structurally_consistent (Q16531)
WDTC1	DDB1	0.999	0.287	structurally_consistent (dimer)
CUL4A	DDA1	0.999	0.12
CUL4A	RBX1	0.998	0.878
DCAF8	CUL4A	0.998	0.146	structurally_consistent (Q16531)
CUL4B	DDB1	0.998	0.272	structurally_consistent (dimer)
CRBN	CUL4B	0.997	0.136	structurally_consistent (Q16531)
WDTC1	CUL4B	0.997	0.092	structurally_consistent (Q16531)
CUL4B	DCAF16	0.997	0.128
DCAF8	CUL4B	0.996	0.034	structurally_consistent (Q16531)
CUL4A	BRWD3	0.996
CUL4B	RBX1	0.996	0.138
DCAF8	DCAF8L1	0.996		structurally_consistent (dimer)
CUL4A	DDB1	0.995	0.628	structurally_consistent (dimer)
CUL4B	DDA1	0.994	0.092	structurally_consistent (Q16531)
DDB1	BRWD3	0.991
BRWD3	DDA1	0.989
DCAF8	DDB1	0.987	0.198	structurally_consistent (dimer)
CRBN	CUL4A	0.985	0.228
CRBN	DDB1	0.983	0.307	mixed_interface
DCAF16	DCAF6	0.98	0.054
TENT5A	WDTC1	0.977
CUL4B	DCAF6	0.972	0.096	structurally_consistent (Q16531)
DDB1	RBX1	0.969	0.638
WDTC1	DDA1	0.968	0.13
CUL4A	DCAF6	0.964	0.154	structurally_consistent (Q16531)
DDB1	DCAF16	0.962	0.260682464455
DDA1	DCAF6	0.956	0.078
CUL4B	BRWD3	0.955
TENT5A	DCAF6	0.954
BRWD3	RBX1	0.941
CUL4A	DCAF16	0.927	0.198
DCAF16	DDA1	0.849	0.122
DDB1	DCAF6	0.829	0.256	mutually_exclusive (Q8TEB1) structurally_consistent (dimer)
RBX1	DDA1	0.785	0.306
CRBN	RBX1	0.75	0.3
CRBN	DCAF6	0.688	0.072	mutually_exclusive (Q16531)
DCAF8L1	DDB1	0.63		mutually_exclusive (Q5TAQ9)
WDTC1	CRBN	0.604	0.112	mutually_exclusive (Q16531)
DCAF8L1	DDA1	0.579
DCAF8L1	CUL4B	0.553
CRBN	DCAF16	0.545	0.13
DCAF8	CRBN	0.543	0.07	mutually_exclusive (Q16531)
RBX1	DCAF16	0.461	0.274
DCAF8L1	CUL4A	0.448
RBX1	DCAF6	0.346	0.308579710145
TENT5A	DDA1	0.264
DCAF8	DDA1	0.195	0.112
TENT5A	CUL4A	0.191
TENT5A	DDB1	0.134
TENT5A	CUL4B	0.103
WDTC1	DCAF6	0.102	0.08	mutually_exclusive (Q16531)
DCAF8	DCAF16	0.074	0.1
CRBN	DDA1	0.058	0.034
WDTC1	RBX1	0.051	0.282
DCAF8	BRWD3	0.047
WDTC1	DCAF16	0.04	0.148
WDTC1	DCAF8	0.022	0.154	mutually_exclusive (Q16531)
DCAF8	DCAF6	0.018	0.14	mutually_exclusive (Q16531)
DCAF8	RBX1	0.018	0.134
TENT5A	DCAF8	0.006

Related Complexes

Genename	Complexes
DCAF8L2	huMAP3_00263.1 huMAP3_00860.1 huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11100.1 huMAP3_11271.1 huMAP3_12806.1 huMAP3_13329.1 huMAP3_14528.1
DCAF16	huMAP3_02953.1 huMAP3_03628.1 huMAP3_07590.1 huMAP3_08251.1 huMAP3_08550.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1 huMAP3_14809.1
DCAF6	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_12773.1 huMAP3_14528.1
RBX1	huMAP3_02231.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
DCAF8L1	huMAP3_02149.1 huMAP3_04960.1 huMAP3_10612.1
TENT5A	huMAP3_00306.1 huMAP3_07842.1 huMAP3_07857.1 huMAP3_10612.1 huMAP3_10915.1 huMAP3_14786.1
CRBN	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
CUL4A	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
CUL4B	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
DCAF8	huMAP3_02149.1 huMAP3_04960.1 huMAP3_10612.1
DDB1	huMAP3_02229.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11271.1 huMAP3_14528.1
BRWD3	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
WDTC1	huMAP3_01109.1 huMAP3_07857.1 huMAP3_10612.1 huMAP3_10773.1 huMAP3_14087.1
DDA1	huMAP3_02953.1 huMAP3_05150.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10612.1

Complex Portal: CPX-25394