hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10614.1
Complex Portal: CPX-19366
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LMNB1 | Lamin-B1 | 5 | UniProt NCBI |
| ARL3 | ADP-ribosylation factor-like protein 3 | 5 | UniProt NCBI |
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| FBXO10 | F-box only protein 10 | 5 | UniProt NCBI |
| TBC1D10A | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | 5 | UniProt NCBI |
| LMNB2 | Lamin-B2 | 5 | UniProt NCBI |
| UBL3 | Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) | 4 | UniProt NCBI |
| LMNA | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6741 | 7.17483486175e-05 | 0.25 | INPP5E PDE6D | INPP5E-PDE6D-RPGR complex |
| REAC:R-HSA-5624958 | 0.000167311042734 | 0.25 | INPP5E PDE6D | ARL13B-mediated ciliary trafficking of INPP5E |
| HP:0001651 | 0.000185773831258 | 0.5 | LMNA INPP5E ARL3 PDE6D | Dextrocardia |
| HP:0004307 | 0.000192611932556 | 0.5 | LMNA INPP5E ARL3 PDE6D | Abnormal anatomic location of the heart |
| REAC:R-HSA-5620920 | 0.000343881525142 | 0.375 | INPP5E ARL3 PDE6D | Cargo trafficking to the periciliary membrane |
| HP:0002419 | 0.000550944707746 | 0.375 | INPP5E ARL3 PDE6D | Molar tooth sign on MRI |
| WP:WP4656 | 0.000551678502006 | 0.375 | INPP5E ARL3 PDE6D | Joubert syndrome |
| WP:WP5234 | 0.00067768571707 | 0.375 | INPP5E ARL3 PDE6D | Bardet Biedl syndrome |
| HP:0009002 | 0.000677898190386 | 0.25 | LMNB2 LMNA | Loss of truncal subcutaneous adipose tissue |
| WP:WP5104 | 0.000859567015467 | 0.25 | LMNB2 LMNA | Acquired partial lipodystrophy Barraquer Simons syndrome |
| HP:0002876 | 0.00168976340135 | 0.375 | INPP5E ARL3 PDE6D | Episodic tachypnea |
| HP:0004422 | 0.00267807580994 | 0.375 | INPP5E ARL3 PDE6D | Biparietal narrowing |
| WP:WP5103 | 0.00407177869695 | 0.25 | LMNB2 LMNA | Progeria associated lipodystrophy |
| HP:0002418 | 0.00478067755223 | 0.375 | INPP5E ARL3 PDE6D | Abnormal midbrain morphology |
| WP:WP4803 | 0.00586061652708 | 0.375 | INPP5E ARL3 PDE6D | Ciliopathies |
| HP:0003635 | 0.0063183945919 | 0.25 | LMNB2 LMNA | Loss of subcutaneous adipose tissue in limbs |
| WP:WP5102 | 0.00713174328203 | 0.25 | LMNB2 LMNA | Familial partial lipodystrophy |
| HP:0040069 | 0.00745399581592 | 0.625 | INPP5E LMNB2 LMNA ARL3 PDE6D | Abnormal lower limb bone morphology |
| HP:0011933 | 0.00812142628406 | 0.25 | INPP5E ARL3 | Elongated superior cerebellar peduncle |
| HP:0002789 | 0.00835350536242 | 0.375 | INPP5E ARL3 PDE6D | Tachypnea |
| HP:0000291 | 0.0101490036868 | 0.25 | LMNB2 LMNA | Abnormality of facial adipose tissue |
| HP:0011932 | 0.0101490036868 | 0.25 | INPP5E ARL3 | Abnormal superior cerebellar peduncle morphology |
| HP:0030809 | 0.0114905842879 | 0.5 | LMNB2 INPP5E PDE6D LMNA | Abnormal tongue morphology |
| HP:0001696 | 0.0117675405447 | 0.375 | INPP5E ARL3 PDE6D | Situs inversus totalis |
| HP:0011534 | 0.0125453921352 | 0.375 | INPP5E ARL3 PDE6D | Abnormal spatial orientation of the cardiac segments |
| HP:0000657 | 0.013774736252 | 0.375 | INPP5E ARL3 PDE6D | Oculomotor apraxia |
| HP:0011931 | 0.014877056319 | 0.25 | INPP5E ARL3 | Abnormal cerebellar peduncle morphology |
| HP:0011815 | 0.0164669703279 | 0.375 | INPP5E ARL3 PDE6D | Cephalocele |
| HP:0002084 | 0.0164669703279 | 0.375 | INPP5E ARL3 PDE6D | Encephalocele |
| HP:0002536 | 0.0165069801428 | 0.5 | LMNB2 INPP5E ARL3 PDE6D | Abnormal cortical gyration |
| WP:WP314 | 0.016652650636 | 0.25 | LMNB2 LMNA | Fas ligand pathway and stress induction of heat shock proteins |
| HP:0002335 | 0.0175771621337 | 0.25 | INPP5E PDE6D | Agenesis of cerebellar vermis |
| HP:0012501 | 0.0175771621337 | 0.25 | INPP5E ARL3 | Abnormal brainstem white matter morphology |
| HP:0001829 | 0.0234438911048 | 0.375 | INPP5E ARL3 PDE6D | Foot polydactyly |
| REAC:R-HSA-5617833 | 0.0241789966573 | 0.375 | INPP5E ARL3 PDE6D | Cilium Assembly |
| HP:0000157 | 0.025775746302 | 0.5 | LMNB2 INPP5E PDE6D LMNA | Abnormality of the tongue |
| HP:0410008 | 0.025775746302 | 0.5 | LMNA INPP5E ARL3 PDE6D | Abnormality of the peripheral nervous system |
| HP:0009136 | 0.0259270889741 | 0.375 | INPP5E ARL3 PDE6D | Duplication involving bones of the feet |
| HP:0034237 | 0.0299676437717 | 0.375 | INPP5E ARL3 PDE6D | Open neural tube defect |
| HP:0002251 | 0.0344027510839 | 0.375 | INPP5E ARL3 PDE6D | Aganglionic megacolon |
| HP:0004362 | 0.0344027510839 | 0.375 | INPP5E ARL3 PDE6D | Abnormal enteric ganglion morphology |
| HP:0012331 | 0.035181524859 | 0.375 | INPP5E ARL3 PDE6D | Abnormal autonomic nervous system morphology |
| HP:0025028 | 0.035181524859 | 0.375 | INPP5E ARL3 PDE6D | Abnormal enteric nervous system morphology |
| HP:0005922 | 0.0361615324575 | 0.625 | INPP5E LMNB2 LMNA ARL3 PDE6D | Abnormal hand morphology |
| HP:0002269 | 0.0370193302555 | 0.5 | LMNB2 INPP5E ARL3 PDE6D | Abnormality of neuronal migration |
| HP:0002650 | 0.0451047388874 | 0.625 | INPP5E LMNB2 LMNA ARL3 PDE6D | Scoliosis |
| HP:0012210 | 0.0484427703238 | 0.625 | INPP5E LMNB2 LMNA ARL3 PDE6D | Abnormal renal morphology |
| CORUM:6091 | 0.0499436884912 | 0.125 | LMNA | NF-YA-LaminA complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LMNB1 | LMNA | 1.0 | 0.45 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM | |
| UBL3 | PDE6D | 0.999 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| LMNB1 | LMNB2 | 0.999 | 0.636 |
mutually_exclusive (O43924)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| LMNB2 | LMNA | 0.998 | 0.538 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| PDE6D | INPP5E | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| PDE6D | FBXO10 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDE6D | TBC1D10A | 0.997 | 0.06 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ARL3 | PDE6D | 0.985 | 0.282 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| LMNB1 | PDE6D | 0.978 | 0.174255319149 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LMNB2 | PDE6D | 0.974 | 0.108 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| TBC1D10A | INPP5E | 0.931 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| UBL3 | INPP5E | 0.923 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| FBXO10 | TBC1D10A | 0.77 | bioplex3_WMM WMM_only | ||
| FBXO10 | INPP5E | 0.757 | bioplex3_WMM WMM_only | ||
| UBL3 | FBXO10 | 0.734 | bioplex3_WMM WMM_only | ||
| UBL3 | TBC1D10A | 0.72 | 0.076 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| ARL3 | INPP5E | 0.676 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| ARL3 | TBC1D10A | 0.656 | 0.05 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| ARL3 | FBXO10 | 0.602 | 0.118 | bioplex3_WMM WMM_only | |
| LMNA | PDE6D | 0.459 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UBL3 | ARL3 | 0.328 | 0.064 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| LMNB2 | FBXO10 | 0.251 | 0.076 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LMNB2 | INPP5E | 0.244 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| UBL3 | LMNB2 | 0.213 | 0.14 |
mutually_exclusive (O43924)
|
bioplex_WMM bioplex3_WMM WMM_only |
| LMNB2 | TBC1D10A | 0.205 | 0.086 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| LMNB1 | INPP5E | 0.159 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| LMNB1 | TBC1D10A | 0.124 | 0.190413043478 |
mutually_exclusive (O43924)
|
bioplex_WMM bioplex3_WMM WMM_only |
| UBL3 | LMNA | 0.089 | 0.12 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LMNB2 | ARL3 | 0.061 | 0.122 |
mutually_exclusive (O43924)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| LMNA | INPP5E | 0.053 | bioplex3_WMM WMM_only | ||
| UBL3 | LMNB1 | 0.043 | 0.164 |
mutually_exclusive (O43924)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LMNA | TBC1D10A | 0.043 | 0.118 | bioplex3_WMM WMM_only | |
| LMNB1 | FBXO10 | 0.023 | 0.114 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LMNA | FBXO10 | 0.022 | 0.146 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LMNA | ARL3 | 0.012 | 0.108098360656 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| LMNB1 | ARL3 | 0.001 | 0.16025 |
mutually_exclusive (O43924)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes