hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10622.1
Complex Portal: CPX-14153
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FREM2 | FRAS1-related extracellular matrix protein 2 (ECM3 homolog) | 5 | UniProt NCBI |
| DKKL1 | Dickkopf-like protein 1 (Cancer/testis antigen 34) (CT34) (Protein soggy-1) (SGY-1) | 4 | UniProt NCBI |
| PCSK1N | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | 5 | UniProt NCBI |
| DENND11 | DENN domain-containing protein 11 (DENND11) (Protein LCHN) | 3 | UniProt NCBI |
| GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) | 5 | UniProt NCBI |
| AMD1 | S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] | 5 | UniProt NCBI |
| FAT4 | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | 5 | UniProt NCBI |
| ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] | 5 | UniProt NCBI |
| PCDHGA11 | Protocadherin gamma-A11 (PCDH-gamma-A11) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0370493 | 0.0173515396836 | 0.222222222222 | PCSK1N ADCYAP1 | pituitary gland; cells in anterior [High] |
| HPA:0370492 | 0.0299583882126 | 0.222222222222 | PCSK1N ADCYAP1 | pituitary gland; cells in anterior [>=Medium] |
| HPA:0370000 | 0.0315676720885 | 0.222222222222 | PCSK1N ADCYAP1 | pituitary gland |
| HPA:0370491 | 0.0315676720885 | 0.222222222222 | PCSK1N ADCYAP1 | pituitary gland; cells in anterior [>=Low] |
| WP:WP5053 | 0.0327744959876 | 0.222222222222 | FREM2 FAT4 | Development of ureteric collection system |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DKKL1 | DENND11 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GADD45A | DKKL1 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| AMD1 | DKKL1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FAT4 | DKKL1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PCSK1N | DKKL1 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PCSK1N | ADCYAP1 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PCDHGA11 | DKKL1 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FREM2 | DKKL1 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PCDHGA11 | FAT4 | 0.951 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FAT4 | AMD1 | 0.902 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| FREM2 | PCDHGA11 | 0.723 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GADD45A | FAT4 | 0.562 | bioplex3_WMM WMM_only | ||
| FREM2 | FAT4 | 0.525 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| FAT4 | DENND11 | 0.395 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| GADD45A | DENND11 | 0.387 | bioplex3_WMM WMM_only | ||
| GADD45A | AMD1 | 0.312 | bioplex3_WMM WMM_only | ||
| ADCYAP1 | AMD1 | 0.294 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FREM2 | DENND11 | 0.175 | 0.026 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCSK1N | PCDHGA11 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FREM2 | PCSK1N | 0.105 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AMD1 | DENND11 | 0.093 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| FREM2 | GADD45A | 0.075 | bioplex3_WMM WMM_only | ||
| PCSK1N | AMD1 | 0.071 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FREM2 | AMD1 | 0.063 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCSK1N | GADD45A | 0.042 | bioplex3_WMM WMM_only | ||
| GADD45A | PCDHGA11 | 0.042 | bioplex3_WMM WMM_only | ||
| PCSK1N | FAT4 | 0.041 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PCDHGA11 | AMD1 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PCDHGA11 | DENND11 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ADCYAP1 | FAT4 | 0.031 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| PCSK1N | DENND11 | 0.026 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FREM2 | ADCYAP1 | 0.021 | bioplex3_HEK293 bioplex () |
Related Complexes