hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10627.1
Complex Portal: CPX-13250
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OTUD3 | OTU domain-containing protein 3 (EC 3.4.19.12) | 5 | UniProt NCBI |
| GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | 5 | UniProt NCBI |
| RAB5C | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | 5 | UniProt NCBI |
| HRAS | GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4301 | 0.000390164573598 | 0.5 | RAB5C HRAS | Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells |
| KEGG:04137 | 0.0118173906169 | 0.5 | RAB5C HRAS | Mitophagy - animal |
| REAC:R-HSA-9009391 | 0.019281632575 | 0.5 | GNAT3 HRAS | Extra-nuclear estrogen signaling |
| WP:WP4223 | 0.0270438297073 | 0.5 | RAB5C HRAS | Ras signaling |
| KEGG:04014 | 0.0415303647194 | 0.5 | RAB5C HRAS | Ras signaling pathway |
| CORUM:5922 | 0.049938562206 | 0.25 | HRAS | RAF1-RAS complex, EGF induced |
| CORUM:6219 | 0.049938562206 | 0.25 | HRAS | DGKZ-RASGRP1-HRAS complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| OTUD3 | GNAT3 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OTUD3 | HRAS | 0.984 | 0.296 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GNAT3 | RAB5C | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | ||
| GNAT3 | HRAS | 0.297 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RAB5C | HRAS | 0.095 | 0.45 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
Related Complexes