hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10628.1
Complex Portal: CPX-13888
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPALPP1 | GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) | 3 | UniProt NCBI |
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | 5 | UniProt NCBI |
| SRSF12 | Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19) | 5 | UniProt NCBI |
| MKRN2 | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | 5 | UniProt NCBI |
| IREB2 | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | 5 | UniProt NCBI |
| CHRM4 | Muscarinic acetylcholine receptor M4 | 5 | UniProt NCBI |
| CLK2 | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | 5 | UniProt NCBI |
| GSPT1 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) | 5 | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt NCBI |
| PABPC1L | Polyadenylate-binding protein 1-like | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03015 | 0.000965229215008 | 0.333333333333 | GSPT2 ETF1 PABPC1L | mRNA surveillance pathway |
| WP:WP107 | 0.0356319901131 | 0.222222222222 | GSPT2 ETF1 | Translation factors |
| CORUM:809 | 0.0499842271994 | 0.111111111111 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GSPT2 | GSPT1 | 0.999 | 0.898 |
mutually_exclusive (P62495)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GSPT2 | IREB2 | 0.99 | 0.038 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SRSF12 | CLK2 | 0.987 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| GSPT2 | ETF1 | 0.987 | 0.686 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ETF1 | GSPT1 | 0.983 | 0.648 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| MKRN2 | GSPT2 | 0.983 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| GSPT2 | CLK2 | 0.971 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GPALPP1 | CLK2 | 0.967 | 0.05 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSPT2 | SRSF12 | 0.962 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSPT1 | CHRM4 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MKRN2 | CLK2 | 0.95 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only | |
| CLK2 | GSPT1 | 0.883 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKRN2 | SRSF12 | 0.855 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| IREB2 | CLK2 | 0.854 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKRN2 | IREB2 | 0.854 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKRN2 | GSPT1 | 0.524 | 0.178 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SRSF12 | GSPT1 | 0.382 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only | |
| IREB2 | GSPT1 | 0.356 | 0.064 | bioplex3_WMM WMM_only | |
| GPALPP1 | SRSF12 | 0.171 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | |
| IREB2 | SRSF12 | 0.027 | 0.064 | bioplex3_WMM WMM_only | |
| MKRN2 | ETF1 | 0.025 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MKRN2 | GPALPP1 | 0.014 | 0.086 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| IREB2 | ETF1 | 0.006 | 0.086 | bioplex3_WMM WMM_only | |
| ETF1 | CLK2 | 0.005 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPALPP1 | GSPT1 | 0.004 | 0.034 | youn_WMM gupta_WMM WMM_only | |
| ETF1 | SRSF12 | 0.004 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| ETF1 | GPALPP1 | 0.003 | 0.09 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes