hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10639.1
Complex Portal: CPX-14338
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C6orf136 | Uncharacterized protein C6orf136 | 2 | UniProt NCBI |
| WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | 5 | UniProt NCBI |
| XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 5 | UniProt NCBI |
| PAXX | Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4082 | 0.0249718442456 | 0.333333333333 | WRN | XRCC6-XRCC5-WRN complex |
| CORUM:1217 | 0.0499402709677 | 0.333333333333 | WRN | WRN-TRF2 complex |
| CORUM:5235 | 0.0499402709677 | 0.333333333333 | WRN | WRN-Ku70-Ku80-PARP1 complex |
| CORUM:7282 | 0.0499402709677 | 0.333333333333 | WRN | FEN1-WRN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| XRCC5 | PAXX | 0.991 | 0.13 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| WRN | PAXX | 0.981 | 0.068 | hein_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| C6orf136 | PAXX | 0.968 | 0.028 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WRN | XRCC5 | 0.96 | 0.48 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| XRCC5 | C6orf136 | 0.029 | 0.082 | bioplex3_HEK293 WMM_only |
Related Complexes