hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10642.1
Complex Portal: CPX-23898
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | 5 | UniProt NCBI |
| UNG | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | 5 | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| SNRK | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 5.38065562428e-11 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | CaMK IV-mediated phosphorylation of CREB |
| GO:0005954 | 1.31563155046e-10 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | calcium- and calmodulin-dependent protein kinase complex |
| REAC:R-HSA-442982 | 4.27346139736e-10 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 1.01590075431e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 1.01590075431e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 1.30608654531e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Long-term potentiation |
| WP:WP4875 | 2.0883923344e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Disruption of postsynaptic signaling by CNV |
| REAC:R-HSA-442742 | 3.12154543066e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-3371571 | 3.77850578875e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | HSF1-dependent transactivation |
| REAC:R-HSA-5576892 | 4.53395842532e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Phase 0 - rapid depolarisation |
| REAC:R-HSA-399719 | 5.39727369539e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 5.39727369539e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| WP:WP4756 | 7.65245072268e-09 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Renin angiotensin aldosterone system RAAS |
| REAC:R-HSA-9022692 | 1.01314260706e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Regulation of MECP2 expression and activity |
| WP:WP4008 | 1.08962168682e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | NO cGMP PKG mediated neuroprotection |
| REAC:R-HSA-111997 | 1.16894660556e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | CaM pathway |
| REAC:R-HSA-111933 | 1.16894660556e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Calmodulin induced events |
| REAC:R-HSA-5673000 | 1.16894660556e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | RAF activation |
| REAC:R-HSA-111996 | 1.53368765668e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Ca-dependent events |
| REAC:R-HSA-9656223 | 2.23277738459e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by RAF1 mutants |
| REAC:R-HSA-1489509 | 2.51173679048e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | DAG and IP3 signaling |
| REAC:R-HSA-6802955 | 3.1471608967e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-9609736 | 3.1471608967e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-936837 | 3.1471608967e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Ion transport by P-type ATPases |
| REAC:R-HSA-6802949 | 3.1471608967e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by RAS mutants |
| REAC:R-HSA-6802946 | 3.1471608967e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 3.1471608967e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling downstream of RAS mutants |
| KEGG:04971 | 3.73025454511e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Gastric acid secretion |
| KEGG:04720 | 4.0284537322e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Long-term potentiation |
| REAC:R-HSA-5578775 | 4.31701598099e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Ion homeostasis |
| REAC:R-HSA-112043 | 4.77117693363e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | PLC beta mediated events |
| KEGG:05031 | 5.03086917655e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Amphetamine addiction |
| REAC:R-HSA-112040 | 7.60097837806e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | G-protein mediated events |
| KEGG:04911 | 8.61903082055e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Insulin secretion |
| WP:WP4341 | 9.8133674381e-08 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04912 | 1.03657872165e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | GnRH signaling pathway |
| KEGG:05214 | 1.03657872165e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Glioma |
| KEGG:04750 | 1.10030772082e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Inflammatory mediator regulation of TRP channels |
| REAC:R-HSA-8986944 | 1.24745525372e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Transcriptional Regulation by MECP2 |
| KEGG:04713 | 1.38501251469e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Circadian entrainment |
| KEGG:04925 | 1.46407561561e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Aldosterone synthesis and secretion |
| REAC:R-HSA-6802952 | 1.5644237257e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by BRAF and RAF1 fusions |
| KEGG:04012 | 1.63229922449e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | ErbB signaling pathway |
| KEGG:04740 | 2.22455437517e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Olfactory transduction |
| KEGG:04916 | 2.33706152208e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Melanogenesis |
| WP:WP673 | 2.73824191099e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | ErbB signaling pathway |
| KEGG:04725 | 3.10420403758e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Cholinergic synapse |
| REAC:R-HSA-438064 | 3.46648078993e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Post NMDA receptor activation events |
| KEGG:04922 | 3.55181171997e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Glucagon signaling pathway |
| REAC:R-HSA-6802957 | 4.13514353097e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Oncogenic MAPK signaling |
| KEGG:04066 | 4.78327275688e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | HIF-1 signaling pathway |
| KEGG:04722 | 4.98230154964e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Neurotrophin signaling pathway |
| REAC:R-HSA-877300 | 5.45866299098e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Interferon gamma signaling |
| KEGG:04114 | 5.84108444617e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Oocyte meiosis |
| REAC:R-HSA-111885 | 6.0683312796e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Opioid Signalling |
| WP:WP428 | 6.71243202026e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Wnt signaling |
| REAC:R-HSA-442755 | 6.72765558294e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Activation of NMDA receptors and postsynaptic events |
| KEGG:04728 | 7.06515518644e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Dopaminergic synapse |
| REAC:R-HSA-3371556 | 8.61057377169e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Cellular response to heat stress |
| REAC:R-HSA-5576891 | 8.61057377169e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Cardiac conduction |
| GO:0004683 | 9.61435992643e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | calmodulin-dependent protein kinase activity |
| KEGG:04921 | 9.74070084625e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Oxytocin signaling pathway |
| WP:WP5083 | 9.84065594112e-07 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Neuroinflammation and glutamatergic signaling |
| KEGG:04261 | 1.00789524798e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Adrenergic signaling in cardiomyocytes |
| WP:WP536 | 1.02045626229e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Calcium regulation in cardiac cells |
| KEGG:04148 | 1.19040546073e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Efferocytosis |
| KEGG:04934 | 1.22968992878e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Cushing syndrome |
| KEGG:04217 | 1.78077754874e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Necroptosis |
| WP:WP289 | 1.92306432459e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Myometrial relaxation and contraction pathways |
| KEGG:05152 | 2.3020533386e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Tuberculosis |
| KEGG:04310 | 2.56718224219e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Wnt signaling pathway |
| KEGG:04360 | 2.85454514632e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Axon guidance |
| KEGG:04024 | 3.16534717686e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | cAMP signaling pathway |
| REAC:R-HSA-983712 | 3.98090137841e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Ion channel transport |
| KEGG:04020 | 4.45587121914e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Calcium signaling pathway |
| KEGG:05417 | 5.35055966359e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Lipid and atherosclerosis |
| KEGG:05415 | 5.59381220119e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Diabetic cardiomyopathy |
| KEGG:05205 | 5.59381220119e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Proteoglycans in cancer |
| REAC:R-HSA-397014 | 8.58505749822e-06 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Muscle contraction |
| REAC:R-HSA-112314 | 1.05854142603e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-913531 | 1.59752917105e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Interferon Signaling |
| KEGG:05012 | 1.64357956457e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Parkinson disease |
| REAC:R-HSA-418594 | 2.04162706146e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | G alpha (i) signalling events |
| REAC:R-HSA-112315 | 2.9019356916e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Transmission across Chemical Synapses |
| REAC:R-HSA-5673001 | 3.52039229266e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 3.79352838038e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | MAPK1/MAPK3 signaling |
| REAC:R-HSA-5683057 | 6.58855409274e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | MAPK family signaling cascades |
| REAC:R-HSA-9006925 | 8.45722839136e-05 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Intracellular signaling by second messengers |
| REAC:R-HSA-112316 | 0.000135335223169 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Neuronal System |
| KEGG:05022 | 0.000150631131899 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Pathways of neurodegeneration - multiple diseases |
| KEGG:05200 | 0.000202734552549 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Pathways in cancer |
| GO:0005516 | 0.000229129100643 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | calmodulin binding |
| GO:0004674 | 0.000289222796515 | 1.0 | SNRK CAMK2B CAMK2G CAMK2D CAMK2A | protein serine/threonine kinase activity |
| REAC:R-HSA-388396 | 0.000311311377346 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | GPCR downstream signalling |
| REAC:R-HSA-442729 | 0.000319009353903 | 0.4 | CAMK2B CAMK2G | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde |
| REAC:R-HSA-5663202 | 0.000325092056541 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-372790 | 0.000523441642203 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by GPCR |
| WP:WP5231 | 0.00100346979189 | 0.4 | CAMK2B CAMK2A | Hippocampal synaptogenesis and neurogenesis |
| GO:0004672 | 0.00120957367552 | 1.0 | SNRK CAMK2B CAMK2G CAMK2D CAMK2A | protein kinase activity |
| REAC:R-HSA-382551 | 0.00137916640811 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Transport of small molecules |
| GO:0051924 | 0.00188884895508 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | regulation of calcium ion transport |
| REAC:R-HSA-1280215 | 0.00234382138907 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Cytokine Signaling in Immune system |
| GO:0030666 | 0.00237111493875 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | endocytic vesicle membrane |
| GO:0016773 | 0.00322776192645 | 1.0 | SNRK CAMK2B CAMK2G CAMK2D CAMK2A | phosphotransferase activity, alcohol group as acceptor |
| GO:0016301 | 0.00459458827669 | 1.0 | SNRK CAMK2B CAMK2G CAMK2D CAMK2A | kinase activity |
| REAC:R-HSA-2262752 | 0.00463311209834 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.00481362685522 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Cellular responses to stimuli |
| GO:0043502 | 0.00522817157061 | 0.6 | CAMK2B CAMK2G CAMK2D | regulation of muscle adaptation |
| GO:0043500 | 0.011813517648 | 0.6 | CAMK2B CAMK2G CAMK2D | muscle adaptation |
| GO:0016772 | 0.0119931908441 | 1.0 | SNRK CAMK2B CAMK2G CAMK2D CAMK2A | transferase activity, transferring phosphorus-containing groups |
| GO:0010959 | 0.0130363720333 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | regulation of metal ion transport |
| GO:0010663 | 0.0140440992017 | 0.4 | CAMK2A CAMK2D | positive regulation of striated muscle cell apoptotic process |
| GO:0010666 | 0.0140440992017 | 0.4 | CAMK2A CAMK2D | positive regulation of cardiac muscle cell apoptotic process |
| GO:0014733 | 0.0140440992017 | 0.4 | CAMK2B CAMK2G | regulation of skeletal muscle adaptation |
| GO:0006816 | 0.0175068921761 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | calcium ion transport |
| REAC:R-HSA-212436 | 0.0184390800992 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Generic Transcription Pathway |
| GO:0030139 | 0.0226789727047 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | endocytic vesicle |
| GO:0043269 | 0.0233977310013 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | regulation of monoatomic ion transport |
| REAC:R-HSA-73857 | 0.0284318585439 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | RNA Polymerase II Transcription |
| WP:WP4549 | 0.0347437372246 | 0.4 | CAMK2B CAMK2A | Fragile X syndrome |
| REAC:R-HSA-74160 | 0.046583533294 | 0.8 | CAMK2B CAMK2G CAMK2D CAMK2A | Gene expression (Transcription) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAMK2D | CAMK2G | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| CAMK2B | CAMK2D | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | ||
| CAMK2B | CAMK2G | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | ||
| CAMK2D | CAMK2A | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| CAMK2A | CAMK2G | 0.998 | 0.51 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| SNRK | CAMK2A | 0.997 | 0.138 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAMK2B | CAMK2A | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| UNG | CAMK2D | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| UNG | CAMK2B | 0.284 | bioplex_WMM bioplex3_WMM WMM_only | ||
| UNG | CAMK2G | 0.275 | 0.034 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SNRK | CAMK2G | 0.196 | 0.144 | bioplex3_WMM WMM_only | |
| UNG | CAMK2A | 0.164 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only | |
| SNRK | CAMK2B | 0.076 | bioplex3_WMM WMM_only | ||
| SNRK | CAMK2D | 0.065 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes