hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10650.1

Complex Portal: CPX-19425

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
SETD1B	Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)	5	UniProt NCBI
KMT2D	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	5	UniProt NCBI
HCFC2	Host cell factor 2 (HCF-2) (C2 factor)	5	UniProt NCBI
HCFC1	Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]	5	UniProt NCBI
DPY30	Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)	5	UniProt NCBI
SETD1A	Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)	5	UniProt NCBI
NCOA6	Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)	5	UniProt NCBI
KDM6A	Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)	5	UniProt NCBI
KMT2B	Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)	5	UniProt NCBI
BOD1L1	Biorientation of chromosomes in cell division protein 1-like 1	5	UniProt NCBI
KMT2A	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	5	UniProt NCBI
CXXC1	CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)	5	UniProt NCBI
ZNF318	Zinc finger protein 318 (Endocrine regulatory protein)	5	UniProt NCBI
RBBP5	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)	5	UniProt NCBI
KMT2C	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	5	UniProt NCBI
WDR5	WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)	5	UniProt NCBI
BOD1	Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B)	5	UniProt NCBI
ASH2L	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)	5	UniProt NCBI
ATN1	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9772755	2.56785038047e-41	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	Formation of WDR5-containing histone-modifying complexes
GO:0035097	6.64558349407e-35	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	histone methyltransferase complex
GO:0034708	5.5167999565e-32	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	methyltransferase complex
REAC:R-HSA-212165	3.21267650871e-29	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	Epigenetic regulation of gene expression
CORUM:6470	1.90299124691e-27	0.526315789474	HCFC1 DPY30 ASH2L SETD1B HCFC2 WDR5 RBBP5 BOD1L1 CXXC1 BOD1	Set1B complex
GO:0048188	8.46912966102e-27	0.578947368421	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 CXXC1 RBBP5 BOD1L1 SETD1A BOD1	Set1C/COMPASS complex
CORUM:6469	2.51599697325e-21	0.421052631579	HCFC1 DPY30 WDR5 ASH2L HCFC2 CXXC1 RBBP5 SETD1A	Set1A complex
CORUM:5195	2.51599697325e-21	0.421052631579	ASH2L DPY30 KMT2C KDM6A RBBP5 KMT2B WDR5 NCOA6	PTIP-HMT complex
CORUM:6467	2.45000337316e-18	0.368421052632	ASH2L DPY30 KMT2D KDM6A RBBP5 WDR5 NCOA6	MLL4 complex
CORUM:6461	2.45000337316e-18	0.368421052632	ASH2L DPY30 KMT2C KDM6A RBBP5 WDR5 NCOA6	MLL3 complex
CORUM:6460	8.16080725094e-18	0.368421052632	HCFC1 DPY30 ASH2L KMT2D HCFC2 RBBP5 WDR5	MLL2 complex
GO:0044666	1.2077081575e-17	0.421052631579	ASH2L DPY30 KMT2D KDM6A RBBP5 KMT2C WDR5 NCOA6	MLL3/4 complex
CORUM:3075	5.3783912951e-17	0.368421052632	ASH2L NCOA6 KMT2D KDM6A RBBP5 KMT2C WDR5	UTX-MLL2/3 complex
REAC:R-HSA-3214841	6.37263785083e-17	0.526315789474	ASH2L KMT2A SETD1B KMT2C WDR5 RBBP5 KMT2B KMT2D SETD1A DPY30	PKMTs methylate histone lysines
REAC:R-HSA-8936459	3.58446581857e-16	0.526315789474	ASH2L KMT2A SETD1B KMT2C WDR5 RBBP5 KMT2B KMT2D SETD1A DPY30	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
GO:1990234	1.41656089486e-15	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	transferase complex
CORUM:6462	2.14121927103e-15	0.315789473684	HCFC1 DPY30 ASH2L RBBP5 WDR5 KMT2A	MLL1 complex
REAC:R-HSA-3247509	6.54190243748e-15	0.631578947368	HCFC1 DPY30 ASH2L SETD1B KDM6A KMT2C WDR5 RBBP5 KMT2B KMT2D SETD1A KMT2A	Chromatin modifying enzymes
REAC:R-HSA-4839726	6.54190243748e-15	0.631578947368	HCFC1 DPY30 ASH2L SETD1B KDM6A KMT2C WDR5 RBBP5 KMT2B KMT2D SETD1A KMT2A	Chromatin organization
REAC:R-HSA-74160	5.13906410921e-14	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	Gene expression (Transcription)
CORUM:6851	7.99259977645e-14	0.263157894737	RBBP5 ASH2L DPY30 WDR5 KMT2A	MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30)
WP:WP5351	3.43759884583e-13	0.368421052632	ASH2L DPY30 KMT2C KDM6A RBBP5 WDR5 NCOA6	Kleefstra syndrome
CORUM:2730	4.79173042039e-13	0.263157894737	SETD1B ASH2L CXXC1 WDR5 RBBP5	Set1B complex
CORUM:2731	4.79173042039e-13	0.263157894737	RBBP5 ASH2L SETD1A WDR5 CXXC1	Set1A complex
GO:0140513	5.76954939377e-13	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	nuclear protein-containing complex
GO:0044665	7.59123394167e-13	0.421052631579	HCFC1 KMT2A ASH2L HCFC2 RBBP5 KMT2B WDR5 DPY30	MLL1/2 complex
CORUM:1254	1.67576636352e-12	0.263157894737	RBBP5 ASH2L DPY30 WDR5 KMT2B	Menin-associated histone methyltransferase complex
CORUM:1256	1.67576636352e-12	0.263157894737	HCFC1 ASH2L KMT2A WDR5 RBBP5	MLL-HCF complex
CORUM:1400	1.67576636352e-12	0.263157894737	KMT2D ASH2L NCOA6 KMT2C RBBP5	ASCOM complex
REAC:R-HSA-8878171	7.84783093052e-12	0.526315789474	ASH2L KMT2A SETD1B KMT2C WDR5 RBBP5 KMT2B KMT2D SETD1A DPY30	Transcriptional regulation by RUNX1
CORUM:1401	2.00610556699e-11	0.263157894737	KMT2D RBBP5 SETD1A WDR5 KMT2A	MOF complex
GO:0042800	4.61766170172e-11	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	histone H3K4 methyltransferase activity
CORUM:6849	7.78532502225e-11	0.210526315789	RBBP5 ASH2L DPY30 WDR5	WRAD complex (WDR5, RBBP5, ASH2L, DPY30)
CORUM:1399	7.78532502225e-11	0.210526315789	KMT2D ASH2L WDR5 RBBP5	WDR5-ASH2L-RBBP5-MLL2 complex
CORUM:6457	7.78532502225e-11	0.210526315789	RBBP5 ASH2L KMT2A WDR5	MLL1 core complex
REAC:R-HSA-5617472	1.24011759032e-10	0.421052631579	ASH2L DPY30 KMT2D KDM6A RBBP5 KMT2C WDR5 NCOA6	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-5619507	1.24011759032e-10	0.421052631579	ASH2L DPY30 KMT2D KDM6A RBBP5 KMT2C WDR5 NCOA6	Activation of HOX genes during differentiation
GO:1902494	1.36896248665e-10	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	catalytic complex
GO:0071339	2.30752658711e-10	0.368421052632	HCFC1 KMT2A ASH2L HCFC2 RBBP5 WDR5 DPY30	MLL1 complex
KEGG:00310	4.54342778966e-09	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	Lysine degradation
CORUM:5386	5.17003622911e-09	0.263157894737	HCFC1 ASH2L KMT2A WDR5 RBBP5	MLL1-WDR5 complex
WP:WP2369	1.48108402954e-08	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	Histone modifications
CORUM:7367	7.10994807657e-08	0.157894736842	RBBP5 WDR5 ASH2L	ASH2L-KDM6B-KDM6B-WDR5 complex
CORUM:6850	7.10994807657e-08	0.157894736842	RBBP5 WDR5 ASH2L	WRA complex (WDR5, RBBP5, ASH2L)
CORUM:2721	1.40302566044e-07	0.210526315789	HCFC1 ASH2L SETD1A WDR5	HCF-1 complex
GO:0005654	1.44854000919e-07	1.0	HCFC1 ATN1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B ZNF318 KMT2D CXXC1 SETD1A NCOA6	nucleoplasm
GO:0140938	1.59287823564e-07	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	histone H3 methyltransferase activity
CORUM:6845	2.84164363312e-07	0.157894736842	RBBP5 WDR5 ASH2L	NIF1-ASH2L-RBBP5-WDR5 complex
GO:0031981	4.94854940784e-07	1.0	HCFC1 ATN1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B ZNF318 KMT2D CXXC1 SETD1A NCOA6	nuclear lumen
CORUM:6340	7.0982748846e-07	0.157894736842	KMT2D ASH2L RBBP5	PITX2-MLL4-ASH2L-RBBP5-PTIP complex
GO:0042054	9.11512739878e-07	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	histone methyltransferase activity
GO:0016279	1.04410645596e-06	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	protein-lysine N-methyltransferase activity
GO:0016278	1.19235273002e-06	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	lysine N-methyltransferase activity
GO:0006325	2.78633042066e-06	0.526315789474	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A HCFC2 RBBP5 SETD1A KMT2A	chromatin organization
GO:0071824	1.17746128653e-05	0.526315789474	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A HCFC2 RBBP5 SETD1A KMT2A	protein-DNA complex organization
GO:0008170	1.9165051771e-05	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	N-methyltransferase activity
GO:0045815	2.06345656599e-05	0.263157894737	RBBP5 ASH2L DPY30 WDR5 KMT2A	transcription initiation-coupled chromatin remodeling
GO:0141137	2.42998708294e-05	0.263157894737	RBBP5 ASH2L DPY30 WDR5 KMT2A	positive regulation of gene expression, epigenetic
GO:0008276	2.4390619444e-05	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	protein methyltransferase activity
KEGG:04934	2.5968432905e-05	0.263157894737	KMT2D ASH2L KMT2A WDR5 RBBP5	Cushing syndrome
GO:0006338	2.67217762483e-05	0.473684210526	HCFC1 DPY30 ASH2L KMT2D KDM6A HCFC2 RBBP5 WDR5 KMT2A	chromatin remodeling
GO:0043233	2.96235023043e-05	1.0	HCFC1 ATN1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B ZNF318 KMT2D CXXC1 SETD1A NCOA6	organelle lumen
GO:0070013	2.96235023043e-05	1.0	HCFC1 ATN1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B ZNF318 KMT2D CXXC1 SETD1A NCOA6	intracellular organelle lumen
GO:0031974	2.96235023043e-05	1.0	HCFC1 ATN1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B ZNF318 KMT2D CXXC1 SETD1A NCOA6	membrane-enclosed lumen
HP:0007655	4.12937936726e-05	0.157894736842	KMT2D KDM6A KMT2A	Eversion of lateral third of lower eyelids
GO:0140993	4.24648525163e-05	0.368421052632	KMT2A SETD1B KDM6A KMT2C KMT2B KMT2D SETD1A	histone modifying activity
REAC:R-HSA-212436	4.25338503829e-05	0.526315789474	ASH2L KMT2A SETD1B KMT2C WDR5 RBBP5 KMT2B KMT2D SETD1A DPY30	Generic Transcription Pathway
REAC:R-HSA-73857	0.000119365906763	0.526315789474	ASH2L KMT2A SETD1B KMT2C WDR5 RBBP5 KMT2B KMT2D SETD1A DPY30	RNA Polymerase II Transcription
REAC:R-HSA-1266738	0.00012381440549	0.473684210526	ASH2L KMT2A KMT2D KDM6A RBBP5 KMT2C NCOA6 WDR5 DPY30	Developmental Biology
CORUM:1257	0.000228186606522	0.157894736842	RBBP5 KMT2A WDR5	ALL-1 supercomplex
HP:0011298	0.000245876330483	0.210526315789	KMT2D KDM6A ATN1 KMT2A	Prominent digit pad
GO:0008757	0.000495666729151	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	S-adenosylmethionine-dependent methyltransferase activity
GO:0005634	0.000568177747297	1.0	HCFC1 ATN1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B ZNF318 KMT2D CXXC1 SETD1A NCOA6	nucleus
GO:0006352	0.00100597053208	0.315789473684	ASH2L KMT2A NCOA6 RBBP5 WDR5 DPY30	DNA-templated transcription initiation
GO:0008168	0.00118549907552	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	methyltransferase activity
GO:0016741	0.00168776856918	0.315789473684	KMT2A SETD1B KMT2B KMT2C KMT2D SETD1A	transferase activity, transferring one-carbon groups
GO:0040029	0.00211155398403	0.315789473684	ASH2L DPY30 KMT2D RBBP5 WDR5 KMT2A	epigenetic regulation of gene expression
CORUM:7221	0.00218827065477	0.105263157895	HCFC1 WDR5	NSL complex
GO:0006351	0.00288226605872	0.736842105263	HCFC1 DPY30 WDR5 ASH2L KMT2D HCFC2 ATN1 KMT2A RBBP5 KMT2B ZNF318 KMT2C CXXC1 NCOA6	DNA-templated transcription
GO:0032774	0.00331570979635	0.736842105263	HCFC1 DPY30 WDR5 ASH2L KMT2D HCFC2 ATN1 KMT2A RBBP5 KMT2B ZNF318 KMT2C CXXC1 NCOA6	RNA biosynthetic process
HP:0009929	0.0037177755523	0.210526315789	KMT2D KDM6A ATN1 KMT2A	Abnormal columella morphology
REAC:R-HSA-3769402	0.00387565273623	0.157894736842	KMT2D ASH2L RBBP5	Deactivation of the beta-catenin transactivating complex
HP:0002000	0.00411758686114	0.157894736842	KMT2D KDM6A KMT2A	Short columella
HP:0000437	0.00467523334077	0.157894736842	KMT2D KDM6A KMT2A	Depressed nasal tip
GO:0045322	0.00519447563198	0.157894736842	CXXC1 KMT2B KMT2A	unmethylated CpG binding
GO:0010557	0.00552419617439	0.631578947368	HCFC1 KMT2A ASH2L KMT2D NCOA6 WDR5 RBBP5 KMT2B ZNF318 KMT2C CXXC1 DPY30	positive regulation of macromolecule biosynthetic process
GO:0031328	0.00768961651133	0.631578947368	HCFC1 KMT2A ASH2L KMT2D NCOA6 WDR5 RBBP5 KMT2B ZNF318 KMT2C CXXC1 DPY30	positive regulation of cellular biosynthetic process
GO:0009891	0.00825838118567	0.631578947368	HCFC1 KMT2A ASH2L KMT2D NCOA6 WDR5 RBBP5 KMT2B ZNF318 KMT2C CXXC1 DPY30	positive regulation of biosynthetic process
KEGG:03083	0.00867690768028	0.157894736842	HCFC1 HCFC2 WDR5	Polycomb repressive complex
GO:0042393	0.00873520889345	0.315789473684	KMT2A KMT2D CXXC1 RBBP5 KMT2C WDR5	histone binding
HP:0004426	0.00877025081157	0.263157894737	SETD1B KDM6A KMT2B SETD1A KMT2D	Abnormal cheek morphology
HP:0005218	0.010658424938	0.105263157895	KMT2D KDM6A	Anoperineal fistula
HP:0010447	0.010658424938	0.105263157895	KMT2D KDM6A	Anal fistula
HP:0000695	0.0131952328072	0.157894736842	KMT2D KDM6A KMT2C	Natal tooth
GO:0006367	0.0153655919446	0.263157894737	RBBP5 ASH2L DPY30 WDR5 KMT2A	transcription initiation at RNA polymerase II promoter
GO:0034654	0.0170063017355	0.736842105263	HCFC1 DPY30 WDR5 ASH2L KMT2D HCFC2 ATN1 KMT2A RBBP5 KMT2B ZNF318 KMT2C CXXC1 NCOA6	nucleobase-containing compound biosynthetic process
GO:0010468	0.0191632060658	0.789473684211	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A ATN1 HCFC2 RBBP5 KMT2A KMT2B ZNF318 KMT2C CXXC1 NCOA6	regulation of gene expression
HP:0001212	0.0198371982787	0.157894736842	KMT2D KDM6A ATN1	Prominent fingertip pads
GO:0018130	0.0215289803313	0.736842105263	HCFC1 DPY30 WDR5 ASH2L KMT2D HCFC2 ATN1 KMT2A RBBP5 KMT2B ZNF318 KMT2C CXXC1 NCOA6	heterocycle biosynthetic process
GO:0019438	0.0218264999669	0.736842105263	HCFC1 DPY30 WDR5 ASH2L KMT2D HCFC2 ATN1 KMT2A RBBP5 KMT2B ZNF318 KMT2C CXXC1 NCOA6	aromatic compound biosynthetic process
HP:0006288	0.023011857337	0.157894736842	KMT2D KDM6A KMT2C	Advanced eruption of teeth
HP:0005819	0.0247174312692	0.157894736842	KMT2D KDM6A KMT2A	Short middle phalanx of finger
MIRNA:hsa-miR-4758-3p	0.0265423485334	0.210526315789	KMT2D BOD1 SETD1A WDR5	hsa-miR-4758-3p
GO:0032991	0.0284728210672	0.894736842105	HCFC1 DPY30 WDR5 ASH2L SETD1B HCFC2 KMT2C KDM6A RBBP5 BOD1 BOD1L1 KMT2A KMT2B KMT2D CXXC1 SETD1A NCOA6	protein-containing complex
GO:0010556	0.0295190390686	0.789473684211	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A ATN1 HCFC2 RBBP5 KMT2A KMT2B ZNF318 KMT2C CXXC1 NCOA6	regulation of macromolecule biosynthetic process
GO:1901362	0.0317085262439	0.736842105263	HCFC1 DPY30 WDR5 ASH2L KMT2D HCFC2 ATN1 KMT2A RBBP5 KMT2B ZNF318 KMT2C CXXC1 NCOA6	organic cyclic compound biosynthetic process
HP:0000826	0.0319451547695	0.210526315789	KMT2D KDM6A KMT2C KMT2B	Precocious puberty
HP:0100000	0.0328440224599	0.210526315789	KMT2D KDM6A KMT2C KMT2B	Early onset of sexual maturation
HP:0009843	0.0367194444717	0.157894736842	KMT2D KDM6A KMT2A	Aplasia/Hypoplasia of the middle phalanges of the hand
REAC:R-HSA-201722	0.0383912543433	0.157894736842	KMT2D ASH2L RBBP5	Formation of the beta-catenin:TCF transactivating complex
HP:0009237	0.0390311591055	0.157894736842	KMT2D KDM6A KMT2A	Short 5th finger
GO:0031326	0.0400373120464	0.789473684211	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A ATN1 HCFC2 RBBP5 KMT2A KMT2B ZNF318 KMT2C CXXC1 NCOA6	regulation of cellular biosynthetic process
GO:0009889	0.0434520554949	0.789473684211	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A ATN1 HCFC2 RBBP5 KMT2A KMT2B ZNF318 KMT2C CXXC1 NCOA6	regulation of biosynthetic process
HP:0006262	0.0439373694848	0.157894736842	KMT2D KDM6A KMT2A	Aplasia/Hypoplasia of the 5th finger
GO:0060255	0.0456546760771	0.842105263158	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A ATN1 HCFC2 RBBP5 BOD1 KMT2A KMT2B ZNF318 KMT2C CXXC1 NCOA6	regulation of macromolecule metabolic process
HP:0000286	0.0464411990393	0.315789473684	KMT2A KMT2D KDM6A ATN1 KMT2B SETD1A	Epicanthus
GO:0031323	0.0472873163382	0.842105263158	HCFC1 DPY30 WDR5 ASH2L KMT2D KDM6A ATN1 HCFC2 RBBP5 BOD1 KMT2A KMT2B ZNF318 KMT2C CXXC1 NCOA6	regulation of cellular metabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RBBP5	ASH2L	1.0	0.438	structurally_consistent (dimer)
CXXC1	RBBP5	1.0	0.27	structurally_consistent (dimer)
RBBP5	SETD1A	1.0	0.208	mutually_exclusive (P61964)
SETD1B	RBBP5	1.0	0.106
CXXC1	SETD1A	1.0	0.46
KMT2A	HCFC2	1.0	0.144
WDR5	RBBP5	1.0	0.574	structurally_consistent (dimer)
CXXC1	WDR5	1.0	0.464	structurally_consistent (dimer)
CXXC1	ASH2L	1.0	0.474	structurally_consistent (Q15291)
CXXC1	SETD1B	1.0	0.236
HCFC2	ASH2L	0.999	0.276
CXXC1	BOD1L1	0.999	0.256
HCFC2	HCFC1	0.999	0.196
HCFC2	SETD1A	0.999	0.462
SETD1B	ASH2L	0.999	0.22
BOD1L1	SETD1A	0.999	0.392
BOD1L1	HCFC2	0.999	0.188
CXXC1	HCFC2	0.999	0.306
SETD1A	ASH2L	0.999	0.566
CXXC1	BOD1	0.999	0.128
KMT2A	RBBP5	0.999	0.156
BOD1L1	RBBP5	0.999	0.324
WDR5	BOD1L1	0.999	0.198
BOD1	ASH2L	0.999	0.182
CXXC1	HCFC1	0.999	0.274
WDR5	ASH2L	0.998	0.236	structurally_consistent (Q15291)
RBBP5	KMT2D	0.998	0.11
WDR5	SETD1A	0.998	0.168	structurally_consistent (dimer)
RBBP5	BOD1	0.998	0.134
DPY30	RBBP5	0.998	0.466
BOD1L1	ASH2L	0.998	0.386
KMT2A	ASH2L	0.997	0.196
CXXC1	DPY30	0.997	0.234	structurally_consistent (P61964)
DPY30	ASH2L	0.997	0.414
SETD1B	BOD1	0.996	0.166
HCFC2	RBBP5	0.996	0.348
WDR5	KMT2B	0.996	0.338
WDR5	KMT2A	0.996	0.228
HCFC2	KMT2B	0.995	0.276
ATN1	WDR5	0.994	0.142	structurally_consistent (dimer)
HCFC1	SETD1A	0.994	0.448
BOD1L1	HCFC1	0.993	0.138
WDR5	SETD1B	0.993	0.172
KDM6A	RBBP5	0.993	0.316	mutually_exclusive (P61964)
WDR5	HCFC1	0.992	0.14
HCFC1	ASH2L	0.992	0.168
HCFC1	RBBP5	0.989	0.068
WDR5	HCFC2	0.988	0.192
NCOA6	WDR5	0.984	0.352
KMT2B	ZNF318	0.983	0.2
KDM6A	KMT2D	0.983	0.192
RBBP5	KMT2B	0.982	0.196
WDR5	KMT2D	0.982	0.0641691542289
WDR5	KDM6A	0.981	0.312	structurally_consistent (dimer)
BOD1L1	KDM6A	0.98	0.15
ASH2L	KMT2D	0.978	0.09203125
ASH2L	KMT2B	0.977	0.21
SETD1B	KDM6A	0.976	0.28
KMT2A	KDM6A	0.976	0.284
WDR5	DPY30	0.973	0.3825	structurally_consistent (dimer)
KDM6A	ASH2L	0.973	0.204
RBBP5	KMT2C	0.972	0.094
KMT2A	KMT2D	0.969	0.118
BOD1L1	KMT2D	0.968	0.098
SETD1B	KMT2D	0.966	0.124
ATN1	RBBP5	0.964	0.12	mutually_exclusive (P61964)
WDR5	BOD1	0.962	0.222
CXXC1	KMT2A	0.962	0.196
SETD1B	SETD1A	0.96	0.304
KMT2C	ASH2L	0.955	0.082
BOD1L1	BOD1	0.955	0.132
SETD1A	KMT2D	0.95	0.102
BOD1L1	KMT2A	0.947	0.18
SETD1B	KMT2A	0.946	0.222
HCFC2	DPY30	0.945	0.34
BOD1L1	SETD1B	0.945	0.196
CXXC1	KDM6A	0.943	0.208
KMT2A	SETD1A	0.941	0.204
BOD1	SETD1A	0.94	0.062
SETD1B	HCFC1	0.94	0.14
KDM6A	SETD1A	0.93	0.228
CXXC1	KMT2D	0.922	0.218
ATN1	SETD1A	0.92	0.15	mutually_exclusive (P61964)
CXXC1	ATN1	0.902	0.316
KDM6A	HCFC1	0.853	0.12
SETD1B	HCFC2	0.842	0.154
NCOA6	ASH2L	0.835	0.318
KMT2A	HCFC1	0.825	0.09
KDM6A	DPY30	0.824	0.212
ATN1	ASH2L	0.811	0.194
NCOA6	RBBP5	0.805	0.346
SETD1B	KMT2B	0.802	0.27
NCOA6	BOD1	0.798	0.134
KDM6A	BOD1	0.798	0.152
BOD1	KMT2D	0.798	0.134
BOD1	KMT2B	0.795	0.112
NCOA6	SETD1B	0.791	0.192
HCFC2	KDM6A	0.769	0.22
SETD1A	KMT2B	0.768	0.236
NCOA6	KMT2D	0.759	0.118
CXXC1	KMT2B	0.751	0.322
HCFC1	KMT2B	0.737	0.124
DPY30	KMT2B	0.717	0.242
ATN1	KMT2A	0.712	0.152
HCFC1	BOD1	0.705	0.226
DPY30	BOD1	0.673	0.104
ATN1	HCFC1	0.672	0.126
NCOA6	KDM6A	0.671	0.268
NCOA6	BOD1L1	0.641	0.242
DPY30	SETD1A	0.606	0.154
KMT2B	KMT2D	0.594	0.166
ATN1	HCFC2	0.592	0.218
DPY30	KMT2D	0.589	0.184
NCOA6	KMT2B	0.566	0.12
NCOA6	KMT2A	0.533	0.14
KDM6A	KMT2B	0.524	0.258
KMT2A	KMT2B	0.511	0.23
BOD1L1	KMT2B	0.505	0.186
BOD1L1	DPY30	0.499	0.362
CXXC1	NCOA6	0.469	0.216
SETD1B	DPY30	0.452	0.212
HCFC2	KMT2D	0.449	0.08
ATN1	KMT2B	0.446	0.168
ATN1	BOD1L1	0.431	0.186
NCOA6	ATN1	0.417	0.296
ATN1	SETD1B	0.401	0.318
ATN1	KMT2D	0.4	0.152
NCOA6	SETD1A	0.398	0.206
ATN1	KDM6A	0.389	0.226
HCFC1	KMT2D	0.381	0.088
KMT2A	BOD1	0.373	0.15
KMT2A	DPY30	0.362	0.078
ATN1	BOD1	0.357	0.098
NCOA6	HCFC2	0.293	0.212
NCOA6	KMT2C	0.288	0.126
HCFC2	BOD1	0.276	0.236
NCOA6	HCFC1	0.273	0.184
KDM6A	KMT2C	0.266	0.166
ATN1	KMT2C	0.21	0.128
HCFC1	DPY30	0.193	0.164
ATN1	DPY30	0.128	0.222	mutually_exclusive (P61964)
NCOA6	DPY30	0.117	0.366
KMT2C	KMT2D	0.099	0.046
KMT2C	SETD1A	0.095	0.144
CXXC1	KMT2C	0.095	0.144
HCFC2	KMT2C	0.082	0.112
WDR5	KMT2C	0.081	0.042
SETD1B	KMT2C	0.079	0.104
BOD1L1	KMT2C	0.079	0.096
KMT2C	KMT2B	0.079	0.092
KMT2C	BOD1	0.079	0.096
DPY30	KMT2C	0.078	0.1
KMT2A	KMT2C	0.071	0.07
KDM6A	ZNF318	0.041	0.128
CXXC1	ZNF318	0.028	0.15
HCFC1	KMT2C	0.024	0.19
HCFC1	ZNF318	0.019	0.096
SETD1A	ZNF318	0.015	0.14
ASH2L	ZNF318	0.014	0.108
SETD1B	ZNF318	0.014	0.072
NCOA6	ZNF318	0.012	0.178
BOD1L1	ZNF318	0.011	0.262
WDR5	ZNF318	0.011	0.144
ZNF318	KMT2D	0.01	0.126
KMT2A	ZNF318	0.009	0.182
DPY30	ZNF318	0.006	0.14
ATN1	ZNF318	0.006	0.126
RBBP5	ZNF318	0.004	0.13
KMT2C	ZNF318	0.004	0.04
HCFC2	ZNF318	0.001	0.1524

Related Complexes

Genename	Complexes
SETD1B	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2D	huMAP3_07585.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_12119.1 huMAP3_12373.1 huMAP3_14057.1 huMAP3_14367.1
HCFC2	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
HCFC1	huMAP3_00564.1 huMAP3_02029.1 huMAP3_07065.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09094.1 huMAP3_10106.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_13421.1
DPY30	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_13844.1
SETD1A	huMAP3_02698.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
NCOA6	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KDM6A	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2B	huMAP3_05393.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_15009.1
BOD1L1	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2A	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
CXXC1	huMAP3_00047.1 huMAP3_02698.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
ZNF318	huMAP3_05393.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_14935.1 huMAP3_15009.1
RBBP5	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2C	huMAP3_00564.1 huMAP3_05226.1 huMAP3_06804.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_12999.1
WDR5	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
BOD1	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_11792.1 huMAP3_15215.1
ASH2L	huMAP3_05226.1 huMAP3_06804.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
ATN1	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10650.1

Complex Portal: CPX-19425