hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10657.1
Complex Portal: CPX-22352
Confidence: Medium High
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
ABHD15 | Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) | 4 | UniProt NCBI |
AKT1 | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) | 5 | UniProt NCBI |
AKT2 | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta) | 5 | UniProt NCBI |
AKT3 | RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) | 5 | UniProt NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
REAC:R-HSA-211163 | 5.61256101945e-09 | 0.75 | AKT1 AKT3 AKT2 | AKT-mediated inactivation of FOXO1A |
REAC:R-HSA-8941332 | 1.40306823124e-08 | 0.75 | AKT1 AKT3 AKT2 | RUNX2 regulates genes involved in cell migration |
REAC:R-HSA-198693 | 1.68324973574e-07 | 0.75 | AKT1 AKT3 AKT2 | AKT phosphorylates targets in the nucleus |
WP:WP5372 | 1.95604750042e-07 | 0.75 | AKT1 AKT3 AKT2 | Involvement of secretase in neurodegenerative diseases |
REAC:R-HSA-6804759 | 2.31434954766e-07 | 0.75 | AKT1 AKT3 AKT2 | Regulation of TP53 Activity through Association with Co-factors |
REAC:R-HSA-9614399 | 3.0856409449e-07 | 0.75 | AKT1 AKT3 AKT2 | Regulation of localization of FOXO transcription factors |
REAC:R-HSA-1358803 | 3.0856409449e-07 | 0.75 | AKT1 AKT3 AKT2 | Downregulation of ERBB2:ERBB3 signaling |
REAC:R-HSA-210745 | 3.0856409449e-07 | 0.75 | AKT1 AKT3 AKT2 | Regulation of gene expression in beta cells |
REAC:R-HSA-9755779 | 3.0856409449e-07 | 0.75 | AKT1 AKT3 AKT2 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways |
WP:WP5294 | 3.38413923581e-07 | 0.75 | AKT1 AKT3 AKT2 | Sildenafil treatment |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
---|---|---|---|---|---|
AKT1 | AKT2 | 0.999 | 0.376 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
AKT1 | AKT3 | 0.999 | 0.278 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
AKT1 | ABHD15 | 0.982 | 0.195829959514 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
ABHD15 | AKT3 | 0.982 | 0.198 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
AKT3 | AKT2 | 0.897 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | |
ABHD15 | AKT2 | 0.401 | 0.13 | bioplex3_WMM WMM_only |
Related Complexes
Genename | Complexes |
---|---|
AKT1 | huMAP3_02055.1 huMAP3_10657.1 |
AKT3 | huMAP3_02055.1 huMAP3_10657.1 huMAP3_13837.1 huMAP3_14477.1 |
ABHD15 | huMAP3_02055.1 huMAP3_10657.1 huMAP3_13774.1 huMAP3_14723.1 |
AKT2 | huMAP3_04364.1 huMAP3_10657.1 huMAP3_13151.1 |