hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10660.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNF253 | Zinc finger protein 253 (Bone marrow zinc finger 1) (BMZF-1) (Zinc finger protein 411) | 4 | UniProt NCBI |
| PGBD2 | PiggyBac transposable element-derived protein 2 | 2 | UniProt NCBI |
| FAXC | Failed axon connections homolog | 3 | UniProt NCBI |
| APOOL | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | 5 | UniProt NCBI |
| TRAK1 | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | 5 | UniProt NCBI |
| SAMM50 | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | 5 | UniProt NCBI |
| IMMT | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | 5 | UniProt NCBI |
| MTX3 | Metaxin-3 | 4 | UniProt NCBI |
| MTX2 | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | 5 | UniProt NCBI |
| USP9Y | Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y) | 5 | UniProt NCBI |
| CRACR2B | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | 5 | UniProt NCBI |
| CARD19 | Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD) | 5 | UniProt NCBI |
| NIPBL | Nipped-B-like protein (Delangin) (SCC2 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6249 | 4.4260376452e-09 | 0.307692307692 | MTX2 IMMT APOOL SAMM50 | MIB complex |
| GO:0001401 | 9.14893106478e-09 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | SAM complex |
| GO:0140275 | 9.14893106478e-09 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | MIB complex |
| GO:0005742 | 1.7844419879e-07 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | mitochondrial outer membrane translocase complex |
| GO:0098799 | 2.34101066656e-07 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | outer mitochondrial membrane protein complex |
| REAC:R-HSA-8949613 | 2.78151129819e-06 | 0.307692307692 | MTX2 IMMT APOOL SAMM50 | Cristae formation |
| GO:0007007 | 7.5044879348e-06 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | inner mitochondrial membrane organization |
| REAC:R-HSA-1592230 | 0.000209654199233 | 0.307692307692 | MTX2 IMMT APOOL SAMM50 | Mitochondrial biogenesis |
| GO:0007006 | 0.000366472005037 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | mitochondrial membrane organization |
| CORUM:6255 | 0.000614265253436 | 0.153846153846 | IMMT APOOL | MICOS complex |
| KEGG:04137 | 0.00455600237314 | 0.230769230769 | MTX3 SAMM50 MTX2 | Mitophagy - animal |
| GO:0098800 | 0.00579896864669 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | inner mitochondrial membrane protein complex |
| GO:0005741 | 0.00831673252973 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | mitochondrial outer membrane |
| GO:0031968 | 0.0134521910719 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | organelle outer membrane |
| GO:0019867 | 0.0138414759818 | 0.384615384615 | MTX2 IMMT MTX3 APOOL SAMM50 | outer membrane |
| GO:0042407 | 0.0152921671063 | 0.230769230769 | IMMT APOOL SAMM50 | cristae formation |
| REAC:R-HSA-1852241 | 0.0209568848266 | 0.307692307692 | MTX2 IMMT APOOL SAMM50 | Organelle biogenesis and maintenance |
| HPA:0241103 | 0.0227264022378 | 0.461538461538 | CRACR2B APOOL SAMM50 IMMT TRAK1 MTX2 | heart muscle; cardiomyocytes[High] |
| GO:0007005 | 0.0243137063548 | 0.461538461538 | MTX3 APOOL SAMM50 IMMT TRAK1 MTX2 | mitochondrion organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| SAMM50 | MTX2 | 1.0 | 0.958 |
| IMMT | MTX2 | 1.0 | |
| MTX2 | CARD19 | 1.0 | 0.27 |
| TRAK1 | CARD19 | 0.999 | |
| FAXC | PGBD2 | 0.999 | |
| MTX3 | MTX2 | 0.998 | 0.32 |
| FAXC | CARD19 | 0.998 | |
| IMMT | CARD19 | 0.998 | |
| SAMM50 | CARD19 | 0.998 | 0.26 |
| SAMM50 | IMMT | 0.998 | |
| TRAK1 | SAMM50 | 0.997 | |
| MTX3 | CARD19 | 0.995 | 0.116 |
| FAXC | USP9Y | 0.993 | |
| TRAK1 | IMMT | 0.993 | |
| SAMM50 | MTX3 | 0.985 | 0.404 |
| IMMT | MTX3 | 0.983 | |
| TRAK1 | MTX2 | 0.982 | |
| APOOL | CARD19 | 0.978 | 0.196 |
| FAXC | SAMM50 | 0.975 | |
| FAXC | ZNF253 | 0.972 | |
| CRACR2B | CARD19 | 0.971 | |
| FAXC | NIPBL | 0.969 | |
| FAXC | IMMT | 0.968 | |
| FAXC | MTX3 | 0.965 | |
| FAXC | MTX2 | 0.96 | |
| MTX3 | APOOL | 0.95 | 0.104 |
| SAMM50 | APOOL | 0.948 | 0.144 |
| MTX2 | APOOL | 0.948 | 0.172 |
| IMMT | APOOL | 0.94 | |
| TRAK1 | MTX3 | 0.855 | |
| PGBD2 | APOOL | 0.469 | |
| TRAK1 | APOOL | 0.41 | |
| PGBD2 | CARD19 | 0.389 | |
| PGBD2 | MTX3 | 0.363 | |
| PGBD2 | USP9Y | 0.343 | |
| USP9Y | CARD19 | 0.261 | 0.048 |
| PGBD2 | NIPBL | 0.25 | |
| PGBD2 | MTX2 | 0.246 | |
| PGBD2 | SAMM50 | 0.138 | |
| USP9Y | MTX3 | 0.117 | 0.048 |
| PGBD2 | IMMT | 0.116 | |
| NIPBL | CARD19 | 0.102 | 0.06 |
| PGBD2 | ZNF253 | 0.095 | |
| ZNF253 | NIPBL | 0.093 | |
| NIPBL | MTX3 | 0.084 | 0.046 |
| ZNF253 | CARD19 | 0.076 | |
| USP9Y | MTX2 | 0.072 | 0.05 |
| ZNF253 | MTX3 | 0.058 | |
| NIPBL | MTX2 | 0.047 | 0.09 |
| ZNF253 | USP9Y | 0.041 | |
| ZNF253 | MTX2 | 0.04 | |
| NIPBL | SAMM50 | 0.037 | 0.072 |
| ZNF253 | IMMT | 0.035 | |
| USP9Y | NIPBL | 0.035 | 0.082 |
| IMMT | CRACR2B | 0.033 | |
| ZNF253 | SAMM50 | 0.027 | |
| USP9Y | IMMT | 0.012 | |
| USP9Y | SAMM50 | 0.012 | 0.034 |
| USP9Y | APOOL | 0.011 | 0.04 |
| NIPBL | IMMT | 0.011 |
Related Complexes