hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10664.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASP3 | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | 5 | UniProt NCBI |
| CASP7 | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | 5 | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | 5 | UniProt NCBI |
| LRRN2 | Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) | 4 | UniProt NCBI |
| LRIG3 | Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) | 4 | UniProt NCBI |
| MORN3 | MORN repeat-containing protein 3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111459 | 7.06547360201e-08 | 0.5 | CASP3 CASP7 XIAP | Activation of caspases through apoptosome-mediated cleavage |
| REAC:R-HSA-111469 | 1.41287710844e-07 | 0.5 | CASP3 CASP7 XIAP | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111464 | 1.41287710844e-07 | 0.5 | CASP3 CASP7 XIAP | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| REAC:R-HSA-111463 | 1.41287710844e-07 | 0.5 | CASP3 CASP7 XIAP | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-111461 | 1.55272913081e-06 | 0.5 | CASP3 CASP7 XIAP | Cytochrome c-mediated apoptotic response |
| REAC:R-HSA-111471 | 4.79564882828e-06 | 0.5 | CASP3 CASP7 XIAP | Apoptotic factor-mediated response |
| KEGG:04215 | 7.24261725801e-06 | 0.5 | CASP3 CASP7 XIAP | Apoptosis - multiple species |
| REAC:R-HSA-109606 | 0.000155019643237 | 0.5 | CASP3 CASP7 XIAP | Intrinsic Pathway for Apoptosis |
| WP:WP254 | 0.000169701188809 | 0.5 | CASP3 CASP7 XIAP | Apoptosis |
| WP:WP1772 | 0.000207412358637 | 0.5 | CASP3 CASP7 XIAP | Apoptosis modulation and signaling |
| KEGG:04668 | 0.000271571764431 | 0.5 | CASP3 CASP7 XIAP | TNF signaling pathway |
| WP:WP5090 | 0.0003090931252 | 0.5 | CASP3 CASP7 XIAP | Complement system in neuronal development and plasticity |
| WP:WP3853 | 0.00045276091601 | 0.333333333333 | CASP3 CASP7 | ERK pathway in Huntington 39 s disease |
| KEGG:04210 | 0.000548884136987 | 0.5 | CASP3 CASP7 XIAP | Apoptosis |
| WP:WP5182 | 0.000914914863609 | 0.333333333333 | CASP3 CASP7 | Pro survival signaling of neuroprotectin D1 |
| WP:WP384 | 0.00136659658622 | 0.333333333333 | CASP3 CASP7 | Apoptosis modulation by HSP70 |
| REAC:R-HSA-264870 | 0.0014177632075 | 0.333333333333 | CASP3 CASP7 | Caspase-mediated cleavage of cytoskeletal proteins |
| WP:WP2507 | 0.00171766688832 | 0.333333333333 | CASP3 CASP7 | Nanomaterial induced apoptosis |
| WP:WP4864 | 0.00190817031826 | 0.333333333333 | CASP3 CASP7 | Host pathogen interaction of human coronaviruses apoptosis |
| WP:WP1433 | 0.00326040131097 | 0.333333333333 | CASP7 XIAP | Nucleotide binding oligomerization domain NOD pathway |
| REAC:R-HSA-109581 | 0.00515963455837 | 0.5 | CASP3 CASP7 XIAP | Apoptosis |
| WP:WP2371 | 0.00561973689916 | 0.333333333333 | CASP3 CASP7 | Parkinson 39 s disease pathway |
| WP:WP2036 | 0.00630862924989 | 0.333333333333 | CASP3 CASP7 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| WP:WP314 | 0.00703705758996 | 0.333333333333 | CASP3 CASP7 | Fas ligand pathway and stress induction of heat shock proteins |
| KEGG:05134 | 0.00813218066336 | 0.333333333333 | CASP3 CASP7 | Legionellosis |
| REAC:R-HSA-5357801 | 0.00822159200532 | 0.5 | CASP3 CASP7 XIAP | Programmed Cell Death |
| WP:WP3646 | 0.00861234767009 | 0.333333333333 | CASP3 CASP7 | Hepatitis C and hepatocellular carcinoma |
| WP:WP3286 | 0.00945912219359 | 0.333333333333 | CASP3 XIAP | Copper homeostasis |
| KEGG:05133 | 0.0123104747863 | 0.333333333333 | CASP3 CASP7 | Pertussis |
| WP:WP2374 | 0.0137560784303 | 0.333333333333 | CASP3 CASP7 | Oncostatin M signaling pathway |
| REAC:R-HSA-111465 | 0.0152705482636 | 0.333333333333 | CASP3 CASP7 | Apoptotic cleavage of cellular proteins |
| KEGG:04623 | 0.0173407760832 | 0.333333333333 | CASP3 CASP7 | Cytosolic DNA-sensing pathway |
| KEGG:01524 | 0.0173407760832 | 0.333333333333 | CASP3 XIAP | Platinum drug resistance |
| GO:0072733 | 0.0210651876021 | 0.333333333333 | CASP3 CASP7 | response to staurosporine |
| GO:0072734 | 0.0210651876021 | 0.333333333333 | CASP3 CASP7 | cellular response to staurosporine |
| WP:WP2328 | 0.0220152039288 | 0.333333333333 | CASP3 CASP7 | Allograft rejection |
| WP:WP4298 | 0.0247253656736 | 0.333333333333 | CASP3 CASP7 | Acute viral myocarditis |
| KEGG:05222 | 0.0261678409889 | 0.333333333333 | CASP3 XIAP | Small cell lung cancer |
| KEGG:05200 | 0.0272817161758 | 0.5 | CASP3 CASP7 XIAP | Pathways in cancer |
| KEGG:05145 | 0.029291198851 | 0.333333333333 | CASP3 XIAP | Toxoplasmosis |
| REAC:R-HSA-75153 | 0.0301046858112 | 0.333333333333 | CASP3 CASP7 | Apoptotic execution phase |
| WP:WP231 | 0.0346027913493 | 0.333333333333 | CASP3 CASP7 | TNF alpha signaling pathway |
| REAC:R-HSA-5218859 | 0.0352499509777 | 0.333333333333 | CASP3 XIAP | Regulated Necrosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CASP7 | XIAP | 0.987 | 0.21 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| CASP3 | XIAP | 0.979 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LRRN2 | LRIG3 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRN2 | XIAP | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MORN3 | XIAP | 0.975 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| XIAP | LRIG3 | 0.004 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes