hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10666.1
Complex Portal: CPX-13904
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PSPC1 | Paraspeckle component 1 (Paraspeckle protein 1) | 5 | UniProt NCBI |
| ORC6 | Origin recognition complex subunit 6 | 5 | UniProt NCBI |
| NONO | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | 5 | UniProt NCBI |
| IFI27L1 | Interferon alpha-inducible protein 27-like protein 1 (Interferon-stimulated gene 12c protein) (ISG12(c)) (ISG12C) | 3 | UniProt NCBI |
| SFPQ | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | 5 | UniProt NCBI |
| EWSR1 | RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7285 | 0.000204640425412 | 0.4 | PSPC1 NONO | HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex |
| HPA:0570783 | 0.00159410664141 | 0.8 | PSPC1 EWSR1 ORC6 NONO | testis; preleptotene spermatocytes[High] |
| HPA:0050013 | 0.00605918446772 | 0.6 | PSPC1 EWSR1 NONO | breast; adipocytes[High] |
| HPA:0570782 | 0.0222315456663 | 0.8 | PSPC1 EWSR1 ORC6 NONO | testis; preleptotene spermatocytes[>=Medium] |
| HPA:0301363 | 0.02767916363 | 0.6 | PSPC1 EWSR1 NONO | lung; alveolar cells type I[High] |
| HPA:0460643 | 0.0349961850173 | 0.6 | PSPC1 EWSR1 NONO | skin 1; Langerhans[High] |
| CORUM:330 | 0.0498708842806 | 0.2 | NONO | PSF-p54(nrb) complex |
| CORUM:1760 | 0.0498708842806 | 0.2 | NONO | TOP1-PSF-P54 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NONO | SFPQ | 1.0 | 0.992 |
mutually_exclusive (Q8WXF1)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PSPC1 | NONO | 1.0 | 0.62 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PSPC1 | SFPQ | 0.999 | 0.674 |
mutually_exclusive (Q15233)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| IFI27L1 | ORC6 | 0.979 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ORC6 | NONO | 0.972 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SFPQ | EWSR1 | 0.963 | 0.632 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction treiber_WMM | |
| ORC6 | SFPQ | 0.959 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ORC6 | PSPC1 | 0.957 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ORC6 | EWSR1 | 0.773 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NONO | EWSR1 | 0.54 | 0.446 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM treiber_WMM | |
| IFI27L1 | EWSR1 | 0.256 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| IFI27L1 | SFPQ | 0.203 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| IFI27L1 | NONO | 0.167 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PSPC1 | EWSR1 | 0.123 | 0.434 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| IFI27L1 | PSPC1 | 0.096 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes