hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10672.1

Complex Portal: CPX-20245

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PBX4	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	5	UniProt NCBI
MEIS3	Homeobox protein Meis3 (Meis1-related protein 2)	5	UniProt NCBI
PBX3	Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)	5	UniProt NCBI
MEIS1	Homeobox protein Meis1	5	UniProt NCBI
PBX1	Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)	5	UniProt NCBI
MEIS2	Homeobox protein Meis2 (Meis1-related protein 1)	5	UniProt NCBI
FAM222A	Protein FAM222A	2	UniProt NCBI
PKNOX2	Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)	5	UniProt NCBI
PBX2	Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17)	5	UniProt NCBI
PKNOX1	Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)	5	UniProt NCBI
MAB21L1	Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0001654	1.0717474033e-09	0.727272727273	PBX3 PBX1 MAB21L1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	eye development
GO:0150063	1.25312545097e-09	0.727272727273	PBX3 PBX1 MAB21L1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	visual system development
GO:0048880	1.46078244224e-09	0.727272727273	PBX3 PBX1 MAB21L1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	sensory system development
GO:0007423	1.2645289925e-08	0.727272727273	PBX3 PBX1 MAB21L1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	sensory organ development
GO:0000978	6.96856840347e-06	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987	8.38840719558e-06	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	cis-regulatory region sequence-specific DNA binding
GO:0007420	2.20289712491e-05	0.636363636364	PBX3 PBX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	brain development
GO:0000981	2.31903061672e-05	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0060322	2.96387759332e-05	0.636363636364	PBX3 PBX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	head development
GO:0000977	2.98282503854e-05	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003700	4.03612182402e-05	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	DNA-binding transcription factor activity
GO:0000976	6.37860034593e-05	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	transcription cis-regulatory region binding
GO:0001067	6.4368790623e-05	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	transcription regulatory region nucleic acid binding
GO:1990837	9.68423690508e-05	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	sequence-specific double-stranded DNA binding
GO:0009887	0.000169712293062	0.636363636364	PBX3 PBX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	animal organ morphogenesis
GO:0043565	0.000182844865374	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	sequence-specific DNA binding
GO:0009790	0.000184944385335	0.636363636364	PBX3 PBX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	embryo development
GO:0003690	0.00018731630899	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	double-stranded DNA binding
GO:0007417	0.000445864001487	0.636363636364	PBX3 PBX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	central nervous system development
GO:0140110	0.0010492984696	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	transcription regulator activity
GO:0009653	0.00167600353569	0.818181818182	PBX3 PBX1 PKNOX1 MAB21L1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	anatomical structure morphogenesis
GO:0000785	0.00256434752378	0.727272727273	PBX3 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	chromatin
GO:0003677	0.00282149950693	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	DNA binding
HP:0011230	0.00285887750413	0.181818181818	MEIS2 MAB21L1	Laterally extended eyebrow
GO:0032993	0.0040687875558	0.727272727273	PBX3 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	protein-DNA complex
KEGG:05202	0.00924387452157	0.272727272727	PBX3 MEIS1 PBX1	Transcriptional misregulation in cancer
GO:0006357	0.00930963969897	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	regulation of transcription by RNA polymerase II
WP:WP2857	0.0104891635797	0.272727272727	PBX3 MEIS1 PBX1	Mesodermal commitment pathway
GO:0006366	0.0148548770213	0.818181818182	PBX3 PBX2 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PKNOX2	transcription by RNA polymerase II
REAC:R-HSA-5619507	0.0151956922991	0.272727272727	PKNOX1 MEIS1 PBX1	Activation of HOX genes during differentiation
REAC:R-HSA-5617472	0.0151956922991	0.272727272727	PKNOX1 MEIS1 PBX1	Activation of anterior HOX genes in hindbrain development during early embryogenesis
GO:0048513	0.0290928610634	0.727272727273	PBX3 PBX1 MAB21L1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	animal organ development
GO:0005694	0.0433328582986	0.727272727273	PBX3 PBX1 PKNOX1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	chromosome
GO:0048731	0.0446462031113	0.818181818182	PBX3 PBX1 PKNOX1 MAB21L1 MEIS1 MEIS2 MEIS3 PBX4 PBX2	system development
GO:0009880	0.0459347760023	0.272727272727	MEIS2 MEIS3 MEIS1	embryonic pattern specification

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PBX2	MEIS2	1.0	0.13	structurally_consistent (dimer)
MEIS2	MAB21L1	1.0	0.096
PBX2	MAB21L1	1.0	0.06
PBX3	MEIS2	1.0	0.206
PBX1	MEIS2	1.0	0.174	structurally_consistent (dimer)
MEIS1	MEIS2	0.999
MEIS2	PBX4	0.999		structurally_consistent (dimer)
PKNOX1	PBX4	0.999		structurally_consistent (dimer)
MEIS3	PBX4	0.999		structurally_consistent (dimer)
MEIS1	PBX4	0.997
MEIS1	MAB21L1	0.997
PKNOX1	PBX1	0.996	0.222	structurally_consistent (dimer)
PKNOX1	PBX2	0.995	0.242
PBX3	MAB21L1	0.995	0.084
PBX1	MAB21L1	0.994	0.098
PBX2	PKNOX2	0.992		mutually_exclusive (Q9BYU1)
MEIS2	MEIS3	0.99
PBX3	PKNOX2	0.988
MEIS2	FAM222A	0.983
PBX1	PBX2	0.982	0.246
PBX3	PBX2	0.977	0.182
PBX1	PBX3	0.976	0.142
FAM222A	MAB21L1	0.974
MEIS1	FAM222A	0.973
PBX1	PKNOX2	0.971
PBX2	PBX4	0.959		mutually_exclusive (O14770) structurally_consistent (dimer)
MEIS1	MEIS3	0.959
PBX2	MEIS1	0.953
PBX1	PBX4	0.952
PBX1	MEIS1	0.946
PBX3	MEIS1	0.946
PKNOX1	MEIS3	0.946		mutually_exclusive (Q9BYU1)
PKNOX2	PBX4	0.938		structurally_consistent (dimer)
PBX1	FAM222A	0.934
PBX3	FAM222A	0.912
PBX2	FAM222A	0.896
PBX3	PBX4	0.862
MEIS1	PKNOX2	0.801
PKNOX1	MEIS1	0.77
PKNOX1	MEIS2	0.726	0.164	mutually_exclusive (P40424)
PKNOX1	PKNOX2	0.558
MEIS2	PKNOX2	0.552
MEIS3	PKNOX2	0.415		mutually_exclusive (Q9BYU1)
PBX2	MEIS3	0.35		mutually_exclusive (Q9BYU1)
PKNOX1	PBX3	0.226	0.14
MAB21L1	PBX4	0.224
MAB21L1	PKNOX2	0.188
PBX3	MEIS3	0.058
MAB21L1	MEIS3	0.058
PBX1	MEIS3	0.042

Related Complexes

Genename	Complexes
PBX4	huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
MEIS3	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
PBX3	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
MEIS1	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
PBX1	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
MEIS2	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
FAM222A	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1 huMAP3_14247.1
PKNOX2	huMAP3_06535.1 huMAP3_07040.1 huMAP3_10521.1 huMAP3_10672.1 huMAP3_11161.1
PBX2	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
PKNOX1	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
MAB21L1	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10672.1

Complex Portal: CPX-20245