hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10673.1

Complex Portal: CPX-18336

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
RALA	Ras-related protein Ral-A (EC 3.6.5.2)	5	UniProt NCBI
CALD1	Caldesmon (CDM)	5	UniProt NCBI
CORO1B	Coronin-1B (Coronin-2)	5	UniProt NCBI
API5	Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL)	5	UniProt NCBI
CTTN	Src substrate cortactin (Amplaxin) (Oncogene EMS1)	5	UniProt NCBI
TJP2	Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)	5	UniProt NCBI
APEX1	DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (REF-1) (Redox factor-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]	5	UniProt NCBI
EFHD2	EF-hand domain-containing protein D2 (Swiprosin-1)	4	UniProt NCBI
MAP4	Microtubule-associated protein 4 (MAP-4)	5	UniProt NCBI
UBAP2	Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2)	5	UniProt NCBI
PICALM	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)	5	UniProt NCBI
MYLK	Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]	5	UniProt NCBI
DAPK1	Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)	5	UniProt NCBI
TJP1	Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0045296	9.30400366286e-07	0.666666666667	CALD1 EFHD2 PICALM UBAP2 TJP1 TJP2 CTTN CORO1B	cadherin binding
HPA:0460201	4.21928393291e-06	0.666666666667	PICALM MYLK CTTN CORO1B TJP1 TJP2 MAP4 CALD1	skin 1; endothelial cells[>=Low]
HPA:0470201	6.3819592198e-06	0.666666666667	PICALM MYLK CTTN CORO1B TJP1 TJP2 MAP4 CALD1	skin 2; endothelial cells[>=Low]
HPA:0470202	1.8103064362e-05	0.583333333333	PICALM MYLK MAP4 CORO1B TJP1 CTTN CALD1	skin 2; endothelial cells[>=Medium]
GO:0050839	1.94102253799e-05	0.666666666667	CALD1 EFHD2 PICALM UBAP2 TJP1 TJP2 CTTN CORO1B	cell adhesion molecule binding
CORUM:6076	0.000112726824524	0.166666666667	CTTN MYLK	c-Abl-cortactin-nmMLCK complex
MIRNA:hsa-miR-34a-5p	0.000309999792075	0.666666666667	CALD1 EFHD2 CTTN CORO1B DAPK1 TJP2 MAP4 UBAP2	hsa-miR-34a-5p
HPA:0460202	0.000340384820682	0.5	PICALM MAP4 CORO1B TJP1 CTTN CALD1	skin 1; endothelial cells[>=Medium]
HPA:0470000	0.00526588106599	1.0	API5 CALD1 EFHD2 MYLK MAP4 PICALM CORO1B DAPK1 TJP2 TJP1 CTTN UBAP2	skin 2
HPA:0050000	0.00707023341495	1.0	API5 CALD1 EFHD2 MYLK MAP4 PICALM CORO1B DAPK1 TJP2 TJP1 CTTN UBAP2	breast
HPA:0460000	0.00717717895216	1.0	API5 CALD1 EFHD2 MYLK MAP4 PICALM CORO1B DAPK1 TJP2 TJP1 CTTN UBAP2	skin 1
KEGG:04530	0.00904045358884	0.25	TJP2 CTTN TJP1	Tight junction
REAC:R-HSA-351906	0.00919893032747	0.166666666667	TJP2 TJP1	Apoptotic cleavage of cell adhesion proteins
WP:WP4560	0.00975211067197	0.166666666667	TJP1 MYLK	MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement
HPA:0470203	0.0110399884324	0.333333333333	MAP4 CALD1 MYLK CTTN	skin 2; endothelial cells[High]
HPA:0570802	0.0157433148414	0.583333333333	PICALM EFHD2 CTTN TJP1 TJP2 MAP4 CALD1	testis; sertoli cells[>=Medium]
HPA:0461442	0.0159648317469	0.416666666667	EFHD2 PICALM MAP4 CORO1B CTTN	skin 1; fibrohistiocytic cells[>=Medium]
WP:WP4905	0.0165265007402	0.166666666667	TJP2 TJP1	1q21 1 copy number variation syndrome
HPA:0470181	0.0173932409188	0.416666666667	TJP2 PICALM TJP1 CTTN MAP4	skin 2; cells in granular layer[>=Low]
HPA:0640693	0.0203842718064	0.166666666667	CALD1 MYLK	endometrium; smooth muscle cells[High]
REAC:R-HSA-194315	0.0244883645239	0.416666666667	TJP2 PICALM MYLK CTTN EFHD2	Signaling by Rho GTPases
HPA:0461411	0.0254188364135	0.416666666667	EFHD2 PICALM TJP1 CTTN MAP4	skin 1; cells in spinous layer[>=Low]
REAC:R-HSA-9716542	0.0271853644496	0.416666666667	TJP2 PICALM MYLK CTTN EFHD2	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
HPA:0270000	0.0273218581759	1.0	API5 CALD1 EFHD2 MYLK MAP4 PICALM CORO1B DAPK1 TJP2 TJP1 CTTN UBAP2	kidney
REAC:R-HSA-2028269	0.028496101667	0.166666666667	TJP2 TJP1	Signaling by Hippo
KEGG:05110	0.0311828348417	0.166666666667	TJP2 TJP1	Vibrio cholerae infection
REAC:R-HSA-5627123	0.0316478917957	0.166666666667	CTTN MYLK	RHO GTPases activate PAKs
HPA:0471442	0.0360473774303	0.416666666667	EFHD2 PICALM MAP4 CORO1B CTTN	skin 2; fibrohistiocytic cells[>=Medium]
HPA:0160052	0.0484016362547	0.833333333333	API5 CALD1 DAPK1 CTTN PICALM CORO1B TJP1 TJP2 MAP4 UBAP2	endometrium 1; glandular cells[>=Medium]
HPA:0461441	0.0484416204945	0.416666666667	EFHD2 PICALM MAP4 CORO1B CTTN	skin 1; fibrohistiocytic cells[>=Low]
HPA:0220052	0.0490709150621	0.916666666667	API5 CALD1 EFHD2 MAP4 PICALM CORO1B DAPK1 TJP2 TJP1 CTTN UBAP2	gallbladder; glandular cells[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD
TJP1	TJP2	0.998	0.11
CALD1	PICALM	0.997
CALD1	EFHD2	0.994
CALD1	CTTN	0.991
MAP4	CALD1	0.985
CORO1B	EFHD2	0.982	0.038
CALD1	TJP2	0.974
CALD1	TJP1	0.971
EFHD2	TJP2	0.971	0.038
CTTN	PICALM	0.967	0.244
PICALM	EFHD2	0.964	0.124
API5	CALD1	0.962
CALD1	APEX1	0.961
TJP1	CTTN	0.96	0.208
RALA	PICALM	0.955	0.164
CTTN	UBAP2	0.954	0.146
MYLK	TJP2	0.953	0.052
DAPK1	TJP1	0.951	0.086
CALD1	CORO1B	0.951
TJP1	MYLK	0.927	0.086
RALA	CTTN	0.925	0.27
PICALM	MYLK	0.918	0.09
CTTN	TJP2	0.915	0.22
MAP4	CTTN	0.915
TJP1	UBAP2	0.914	0.064
CTTN	MYLK	0.908	0.078
CORO1B	MYLK	0.819	0.072
RALA	CORO1B	0.8	0.092
PICALM	TJP2	0.738	0.066
UBAP2	TJP2	0.729	0.128
MAP4	APEX1	0.722
TJP1	PICALM	0.684	0.08
CTTN	EFHD2	0.623	0.14
CORO1B	TJP2	0.618	0.102
MAP4	UBAP2	0.569
TJP1	EFHD2	0.524	0.014
RALA	UBAP2	0.487	0.018
API5	APEX1	0.485	0.438
CORO1B	CTTN	0.468	0.326
UBAP2	PICALM	0.439	0.058
TJP1	CORO1B	0.421	0.156
APEX1	EFHD2	0.392	0.19
PICALM	APEX1	0.371	0.148
RALA	TJP2	0.279	0.066
DAPK1	TJP2	0.242	0.098
CALD1	RALA	0.236
API5	MAP4	0.23
MAP4	PICALM	0.229
CALD1	MYLK	0.226
MAP4	RALA	0.206
RALA	EFHD2	0.182	0.054
CORO1B	PICALM	0.146	0.098
RALA	TJP1	0.134	0.136
RALA	APEX1	0.111	0.078
UBAP2	EFHD2	0.1	0.02
EFHD2	MYLK	0.096	0.08
CALD1	UBAP2	0.076
RALA	MYLK	0.039	0.04
CTTN	APEX1	0.039	0.37
API5	CTTN	0.036	0.212
MAP4	TJP1	0.03
MAP4	EFHD2	0.029
DAPK1	PICALM	0.027	0.088
MAP4	CORO1B	0.019
API5	PICALM	0.019	0.102
API5	MYLK	0.014	0.068
DAPK1	CTTN	0.014	0.206
MAP4	TJP2	0.013
UBAP2	MYLK	0.013	0.044
CALD1	DAPK1	0.013
MAP4	MYLK	0.012
API5	RALA	0.011	0.078
MAP4	DAPK1	0.009
API5	UBAP2	0.008	0.12
APEX1	TJP2	0.008	0.392
API5	EFHD2	0.007	0.098
API5	CORO1B	0.006	0.14
TJP1	APEX1	0.005	0.23
UBAP2	APEX1	0.005	0.144
CORO1B	APEX1	0.002	0.166
CORO1B	UBAP2	0.002	0.04
API5	TJP1	0.001	0.184
API5	TJP2	0.001	0.202

Related Complexes

Genename	Complexes
RALA	huMAP3_00361.1 huMAP3_01181.1 huMAP3_01840.1 huMAP3_04177.1 huMAP3_06790.1 huMAP3_08151.1 huMAP3_09440.1 huMAP3_10673.1 huMAP3_13904.1 huMAP3_14624.1
CALD1	huMAP3_00227.1 huMAP3_02119.1 huMAP3_03762.1 huMAP3_06395.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_11653.1 huMAP3_12523.1
CORO1B	huMAP3_01075.1 huMAP3_02173.1 huMAP3_03762.1 huMAP3_04263.1 huMAP3_04826.1 huMAP3_05614.1 huMAP3_06395.1 huMAP3_07117.1 huMAP3_07351.1 huMAP3_07776.1 huMAP3_08255.1 huMAP3_09579.1 huMAP3_09596.1 huMAP3_09808.1 huMAP3_10673.1 huMAP3_10784.1 huMAP3_11076.1
API5	huMAP3_00227.1 huMAP3_02119.1 huMAP3_03762.1 huMAP3_06395.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_11293.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1 huMAP3_14618.1 huMAP3_14750.1 huMAP3_14982.1
CTTN	huMAP3_01553.1 huMAP3_06395.1 huMAP3_10673.1
TJP2	huMAP3_04980.1 huMAP3_05613.1 huMAP3_06395.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_13903.1
APEX1	huMAP3_02119.1 huMAP3_03126.1 huMAP3_03762.1 huMAP3_04783.1 huMAP3_10115.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_13998.1 huMAP3_14442.1
EFHD2	huMAP3_03533.1 huMAP3_03762.1 huMAP3_06395.1 huMAP3_07456.1 huMAP3_10281.1 huMAP3_10673.1 huMAP3_14442.1
MAP4	huMAP3_00227.1 huMAP3_02119.1 huMAP3_03762.1 huMAP3_06395.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_11653.1 huMAP3_11859.1 huMAP3_12523.1
UBAP2	huMAP3_01553.1 huMAP3_02979.1 huMAP3_03309.1 huMAP3_09898.1 huMAP3_10307.1 huMAP3_10523.1 huMAP3_10590.1 huMAP3_10631.1 huMAP3_10673.1 huMAP3_10841.1 huMAP3_10943.1 huMAP3_11111.1 huMAP3_13227.1
PICALM	huMAP3_01840.1 huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10673.1 huMAP3_10762.1 huMAP3_12394.1
MYLK	huMAP3_04980.1 huMAP3_10673.1 huMAP3_11074.1
DAPK1	huMAP3_00438.1 huMAP3_02245.1 huMAP3_03620.1 huMAP3_05773.1 huMAP3_06150.1 huMAP3_09990.1 huMAP3_10673.1 huMAP3_13475.1 huMAP3_14171.1 huMAP3_14231.1
TJP1	huMAP3_01052.1 huMAP3_02245.1 huMAP3_05773.1 huMAP3_06395.1 huMAP3_09990.1 huMAP3_10673.1 huMAP3_13475.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10673.1

Complex Portal: CPX-18336