hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10680.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TXNRD2 | Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3) | 5 | UniProt NCBI |
| PDIA6 | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | 5 | UniProt NCBI |
| TXNRD1 | Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00450 | 5.95130368674e-05 | 0.666666666667 | TXNRD2 TXNRD1 | Selenocompound metabolism |
| GO:0015035 | 0.000351222630093 | 1.0 | TXNRD2 PDIA6 TXNRD1 | protein-disulfide reductase activity |
| WP:WP408 | 0.000427669224246 | 0.666666666667 | TXNRD2 TXNRD1 | Oxidative stress response |
| GO:0015036 | 0.000629105668845 | 1.0 | TXNRD2 PDIA6 TXNRD1 | disulfide oxidoreductase activity |
| GO:0016667 | 0.00177091563679 | 1.0 | TXNRD2 PDIA6 TXNRD1 | oxidoreductase activity, acting on a sulfur group of donors |
| WP:WP15 | 0.00257262049766 | 0.666666666667 | TXNRD2 TXNRD1 | Selenium micronutrient network |
| REAC:R-HSA-3299685 | 0.00257431960226 | 0.666666666667 | TXNRD2 TXNRD1 | Detoxification of Reactive Oxygen Species |
| KEGG:05225 | 0.00952002010149 | 0.666666666667 | TXNRD2 TXNRD1 | Hepatocellular carcinoma |
| REAC:R-HSA-2262752 | 0.0292688889279 | 1.0 | TXNRD2 PDIA6 TXNRD1 | Cellular responses to stress |
| GO:0004791 | 0.0294899169624 | 0.666666666667 | TXNRD2 TXNRD1 | thioredoxin-disulfide reductase (NADP) activity |
| REAC:R-HSA-8953897 | 0.0301284815898 | 1.0 | TXNRD2 PDIA6 TXNRD1 | Cellular responses to stimuli |
| REAC:R-HSA-5263617 | 0.0498224659464 | 0.333333333333 | TXNRD1 | Metabolism of ingested MeSeO2H into MeSeH |
| CORUM:6078 | 0.0499402709677 | 0.333333333333 | PDIA6 | HSPA2-ACR-PDIA6 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TXNRD2 | TXNRD1 | 0.995 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TXNRD1 | PDIA6 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| TXNRD2 | PDIA6 | 0.005 | bioplex3_HEK293 bioplex () |
Related Complexes