hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10687.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FRY | Protein furry homolog | 5 | UniProt NCBI |
| HOMER1 | Homer protein homolog 1 (Homer-1) | 5 | UniProt NCBI |
| HOMER2 | Homer protein homolog 2 (Homer-2) (Cupidin) | 5 | UniProt NCBI |
| HOMER3 | Homer protein homolog 3 (Homer-3) | 5 | UniProt NCBI |
| TRAF5 | TNF receptor-associated factor 5 (RING finger protein 84) | 5 | UniProt NCBI |
| FRYL | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0007216 | 3.84302573496e-05 | 0.5 | HOMER1 HOMER2 HOMER3 | G protein-coupled glutamate receptor signaling pathway |
| GO:2001256 | 3.84302573496e-05 | 0.5 | HOMER1 HOMER2 HOMER3 | regulation of store-operated calcium entry |
| GO:0035256 | 6.72425931667e-05 | 0.5 | HOMER1 HOMER2 HOMER3 | G protein-coupled glutamate receptor binding |
| REAC:R-HSA-6794361 | 0.000106578184795 | 0.5 | HOMER1 HOMER2 HOMER3 | Neurexins and neuroligins |
| KEGG:04724 | 0.000167761438495 | 0.5 | HOMER1 HOMER2 HOMER3 | Glutamatergic synapse |
| GO:0002115 | 0.0002304395259 | 0.5 | HOMER1 HOMER2 HOMER3 | store-operated calcium entry |
| WP:WP5417 | 0.000278673368084 | 0.5 | HOMER1 HOMER2 HOMER3 | Cell lineage map for neuronal differentiation |
| REAC:R-HSA-6794362 | 0.00038290615081 | 0.5 | HOMER1 HOMER2 HOMER3 | Protein-protein interactions at synapses |
| KEGG:04068 | 0.0004581001419 | 0.5 | HOMER1 HOMER2 HOMER3 | FoxO signaling pathway |
| GO:0035254 | 0.00130441648129 | 0.5 | HOMER1 HOMER2 HOMER3 | glutamate receptor binding |
| GO:0007215 | 0.00498056162807 | 0.5 | HOMER1 HOMER2 HOMER3 | glutamate receptor signaling pathway |
| WP:WP5420 | 0.00776281964385 | 0.5 | HOMER1 HOMER2 HOMER3 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-112316 | 0.0294801014222 | 0.5 | HOMER1 HOMER2 HOMER3 | Neuronal System |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HOMER3 | HOMER1 | 1.0 | 0.048 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| HOMER2 | HOMER1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HOMER3 | HOMER2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FRYL | HOMER3 | 0.997 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FRY | FRYL | 0.99 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TRAF5 | HOMER1 | 0.973 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FRYL | HOMER1 | 0.96 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| TRAF5 | HOMER3 | 0.358 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
| TRAF5 | HOMER2 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | |
| FRYL | HOMER2 | 0.193 | bioplex_WMM bioplex3_WMM WMM_only | |
| FRY | HOMER3 | 0.178 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| FRY | HOMER1 | 0.164 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes