hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10697.1

Complex Portal: CPX-24156

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
TSEN54	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	5	UniProt NCBI
TSEN15	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	5	UniProt NCBI
PHLDA2	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	5	UniProt NCBI
AMMECR1	Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein)	5	UniProt NCBI
CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	5	UniProt NCBI
PCF11	Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	9.2015673155e-16	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	tRNA splicing endonuclease
HP:0006850	4.76140718857e-10	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Hypoplasia of the ventral pons
HP:0012765	4.76140718857e-10	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Widened cerebellar subarachnoid space
HP:0200049	2.22101672164e-09	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Upper limb hypertonia
REAC:R-HSA-6784531	7.40079107594e-09	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	tRNA processing in the nucleus
CORUM:5284	9.82248594942e-09	0.375	CLP1 TSEN54 TSEN2	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
HP:0003558	1.04636277272e-08	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Viral infection-induced rhabdomyolysis
HP:0031162	1.56920029308e-08	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Impaired oropharyngeal swallow response
HP:0002268	7.53657938041e-08	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Paroxysmal dystonia
REAC:R-HSA-72306	1.51014067495e-07	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	tRNA processing
HP:0011171	1.89356712338e-07	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Simple febrile seizure
HP:0000253	2.49068095398e-07	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Progressive microcephaly
GO:0006388	6.06890408176e-07	0.5	TSEN34 CLP1 TSEN54 TSEN2	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	9.10136169988e-07	0.5	TSEN34 CLP1 TSEN54 TSEN2	RNA splicing, via endonucleolytic cleavage and ligation
HP:0006895	1.29124729367e-06	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Lower limb hypertonia
HP:0003201	2.59204993656e-06	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Rhabdomyolysis
HP:0012704	2.59204993656e-06	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Widened subarachnoid space
HP:0200136	2.59204993656e-06	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Oral-pharyngeal dysphagia
HP:0025190	2.87942365626e-06	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Bilateral tonic-clonic seizure with generalized onset
HP:0006989	3.19001268559e-06	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Dysplastic corpus callosum
HP:0009062	3.52502992691e-06	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Infantile axial hypotonia
HP:0002509	3.80489896045e-06	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Limb hypertonia
HP:0100704	3.94207794606e-06	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Cerebral visual impairment
GO:0000214	5.38272230028e-06	0.375	CLP1 TSEN54 TSEN2	tRNA-intron endonuclease complex
GO:0000379	5.38272230028e-06	0.375	TSEN34 TSEN54 TSEN2	tRNA-type intron splice site recognition and cleavage
HP:0007598	1.07102958771e-05	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Bilateral single transverse palmar creases
HP:0005484	1.18743275108e-05	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Secondary microcephaly
HP:0012703	4.01043730517e-05	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal subarachnoid space morphology
HP:0007362	4.45688638949e-05	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Aplasia/Hypoplasia of the brainstem
HP:0002365	4.45688638949e-05	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Hypoplasia of the brainstem
HP:0012110	4.45688638949e-05	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Hypoplasia of the pons
REAC:R-HSA-8953854	5.65270307937e-05	0.75	TSEN15 TSEN34 CLP1 TSEN2 PCF11 TSEN54	Metabolism of RNA
HP:0002363	6.01060110342e-05	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormal brainstem morphology
HP:0011471	6.94109434739e-05	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Gastrostomy tube feeding in infancy
HP:0007361	0.000112370900578	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal pons morphology
HP:0008936	0.000120981974268	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Axial hypotonia
HP:0001266	0.000142849891475	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Choreoathetosis
HP:0032892	0.000214257131294	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Infection-related seizure
HP:0032894	0.000214257131294	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Seizure precipitated by febrile infection
HP:0002373	0.000214257131294	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Febrile seizure (within the age range of 3 months to 6 years)
HP:0002123	0.000271794082941	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Generalized myoclonic seizure
HP:0002033	0.00029969273526	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Poor suck
HP:0002536	0.0003105516977	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormal cortical gyration
HP:0012469	0.00037306800449	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Infantile spasms
HP:0002305	0.000559098986096	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Athetosis
HP:0002350	0.000606596843349	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Cerebellar cyst
HP:0002079	0.000791717067198	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Hypoplasia of the corpus callosum
HP:0002269	0.000860420496842	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormality of neuronal migration
HP:0032677	0.000934924157869	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Generalized-onset motor seizure
HP:0000340	0.000957655658581	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Sloping forehead
HP:0002020	0.00105899494705	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Gastroesophageal reflux
HP:0011097	0.0011028115252	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Epileptic spasm
HP:0008947	0.00126376173768	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Infantile muscular hypotonia
HP:0033454	0.00135049795746	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Tube feeding
HP:0000954	0.00141073492194	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Single transverse palmar crease
HP:0010576	0.00150481382461	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Intracranial cystic lesion
HP:0030724	0.00157007694718	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Central nervous system cyst
HP:0011344	0.00163742493148	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Severe global developmental delay
CORUM:1141	0.00186035657619	0.25	CLP1 PCF11	CF IIAm complex (Cleavage factor IIAm complex)
HP:0002104	0.00221340968364	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Apnea
HP:0002072	0.00238962380257	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Chorea
HP:0000290	0.00257784647921	0.75	TSEN15 TSEN34 AMMECR1 CLP1 TSEN2 TSEN54	Abnormality of the forehead
HP:0032794	0.00262432466374	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Myoclonic seizure
HP:0010490	0.00287575816709	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormality of the palmar creases
HP:0001018	0.00314468443624	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal palmar dermatoglyphics
HP:0009127	0.00334538353549	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormality of the musculature of the limbs
HP:0007308	0.00338670821406	0.25	TSEN54 TSEN2	Extrapyramidal dyskinesia
HP:0002438	0.00361329276868	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Cerebellar malformation
HP:0001446	0.00367531861328	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormality of the musculature of the upper limbs
HP:0001320	0.00509011027841	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Cerebellar vermis hypoplasia
HP:0031828	0.00525098184782	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal superficial reflex
HP:0003487	0.00525098184782	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Babinski sign
HP:0007477	0.00677537357422	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal dermatoglyphics
HP:0006817	0.00717720349197	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Aplasia/Hypoplasia of the cerebellar vermis
HP:0002197	0.0084891557618	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Generalized-onset seizure
HP:0002119	0.00870807850572	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Ventriculomegaly
HP:0007370	0.00916119500335	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Aplasia/Hypoplasia of the corpus callosum
REAC:R-HSA-77595	0.00949504138694	0.25	CLP1 PCF11	Processing of Intronless Pre-mRNAs
HP:0002538	0.0101232347273	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormal cerebral cortex morphology
GO:0008033	0.011578905434	0.5	TSEN34 CLP1 TSEN54 TSEN2	tRNA processing
HP:0002334	0.0128561426599	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal cerebellar vermis morphology
HP:0001155	0.0129824874938	0.75	TSEN15 TSEN34 AMMECR1 CLP1 TSEN2 TSEN54	Abnormality of the hand
GO:0000213	0.0131096201623	0.25	TSEN2 TSEN34	tRNA-intron endonuclease activity
HP:0002069	0.0141677251894	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Bilateral tonic-clonic seizure
HP:0033725	0.0152863524979	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Thin corpus callosum
HP:0025270	0.0163010330287	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormal esophagus physiology
HP:0040211	0.0166980348851	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal skin morphology of the palm
REAC:R-HSA-75067	0.0194471683576	0.25	CLP1 PCF11	Processing of Capped Intronless Pre-mRNA
HP:0001257	0.0206511160314	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Spasticity
HP:0002817	0.0209431957013	0.75	TSEN15 TSEN34 AMMECR1 CLP1 TSEN2 TSEN54	Abnormality of the upper limb
HP:0001273	0.0221994338924	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormal corpus callosum morphology
GO:1902555	0.0240219853832	0.375	CLP1 TSEN54 TSEN2	endoribonuclease complex
HP:0020219	0.0244780673068	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Motor seizure
HP:0001270	0.0251278036488	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Motor delay
HP:0007256	0.025775746302	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal pyramidal sign
HP:0002118	0.0263200792391	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Abnormal cerebral ventricle morphology
HP:0001252	0.0318330382783	0.75	TSEN15 TSEN34 AMMECR1 CLP1 TSEN2 TSEN54	Hypotonia
HP:0001321	0.0330409706332	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Cerebellar hypoplasia
GO:1905348	0.0349415747767	0.375	CLP1 TSEN54 TSEN2	endonuclease complex
HP:0002360	0.0370193302555	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Sleep abnormality
HP:0100871	0.0377152211096	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Abnormal palm morphology
HP:0001999	0.0458043395768	0.625	TSEN34 TSEN15 TSEN2 TSEN54 AMMECR1	Abnormal facial shape
HP:0002015	0.0476665887161	0.5	TSEN34 TSEN15 TSEN54 TSEN2	Dysphagia
HP:0000505	0.0477116648657	0.625	TSEN34 TSEN15 TSEN2 TSEN54 CLP1	Visual impairment

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TSEN15	TSEN34	1.0	0.22		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
TSEN15	TSEN2	0.999	0.084	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN2	0.999	0.166		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN34	0.999	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN54	0.999	0.116	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN54	0.999	0.124	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN15	CLP1	0.998	0.07		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN34	0.998	0.12		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CLP1	PCF11	0.997	0.27	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction
TSEN15	TSEN54	0.994	0.098	structurally_consistent (Q8NCE0)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CLP1	AMMECR1	0.981	0.11		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN34	TSEN54	0.971	0.156		bioplex_WMM bioplex3_WMM WMM_only
PHLDA2	CLP1	0.952	0.062		hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN54	AMMECR1	0.907	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN15	PCF11	0.796	0.05		bioplex3_WMM youn_WMM WMM_only
PCF11	TSEN54	0.287	0.134	mutually_exclusive (Q92989)	bioplex3_WMM WMM_only
PCF11	TSEN34	0.215	0.056		bioplex3_WMM youn_WMM WMM_only
PCF11	TSEN2	0.209	0.09		bioplex3_WMM WMM_only
PHLDA2	PCF11	0.135	0.058		bioplex3_WMM WMM_only
PHLDA2	TSEN2	0.122	0.062		bioplex3_WMM WMM_only
TSEN15	PHLDA2	0.086	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN54	0.069	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN34	0.063	0.064		bioplex3_WMM WMM_only
TSEN2	AMMECR1	0.061	0.152		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
TSEN54	huMAP3_04582.1 huMAP3_06042.1 huMAP3_07243.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN15	huMAP3_02940.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_15245.1
PHLDA2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_11956.1 huMAP3_13483.1 huMAP3_13693.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_14984.1
AMMECR1	huMAP3_04582.1 huMAP3_08573.1 huMAP3_08812.1 huMAP3_10697.1 huMAP3_11762.1 huMAP3_13483.1 huMAP3_13511.1 huMAP3_14586.1 huMAP3_14839.1
CLP1	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
PCF11	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_12111.1 huMAP3_13730.1 huMAP3_14483.1 huMAP3_14586.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10697.1

Complex Portal: CPX-24156