hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10702.1
Complex Portal: CPX-20960
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | 5 | UniProt NCBI |
| KGD4 | Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) | 3 | UniProt NCBI |
| DBT | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) | 5 | UniProt NCBI |
| PAGE2B | Putative G antigen family E member 3 (Prostate-associated gene 2B protein) (PAGE-2B) | 2 | UniProt NCBI |
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | 5 | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | 5 | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 3.97003041564e-12 | 0.714285714286 | KGD4 DLST OGDH OGDHL DLD | oxoglutarate dehydrogenase complex |
| GO:0045240 | 8.73008139488e-11 | 0.714285714286 | KGD4 DLST OGDH OGDHL DLD | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 1.16850131892e-09 | 0.714285714286 | KGD4 DLST OGDH OGDHL DLD | tricarboxylic acid cycle enzyme complex |
| KEGG:00785 | 2.93487162541e-09 | 0.571428571429 | OGDH DLST OGDHL DLD | Lipoic acid metabolism |
| KEGG:01210 | 2.62325515445e-08 | 0.571428571429 | OGDH DLST OGDHL DLD | 2-Oxocarboxylic acid metabolism |
| KEGG:00020 | 2.62325515445e-08 | 0.571428571429 | OGDH DLST OGDHL DLD | Citrate cycle (TCA cycle) |
| CORUM:7267 | 2.80877722849e-08 | 0.428571428571 | OGDH DLD DLST | KAT2A-Oxoglutarate dehydrogenase complex |
| GO:0006103 | 6.57500588447e-07 | 0.571428571429 | KGD4 OGDH OGDHL DLST | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71064 | 2.1479923589e-06 | 0.428571428571 | OGDH DLD DLST | Lysine catabolism |
| GO:0004591 | 3.36420143768e-06 | 0.428571428571 | KGD4 OGDHL OGDH | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| WP:WP2453 | 3.40385763581e-06 | 0.428571428571 | OGDH DLD DLST | TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc |
| KEGG:01200 | 4.34806074029e-06 | 0.571428571429 | OGDH DLST OGDHL DLD | Carbon metabolism |
| WP:WP78 | 4.9578692769e-06 | 0.428571428571 | OGDH DLD DLST | TCA cycle aka Krebs or citric acid cycle |
| GO:0006099 | 9.75381672605e-06 | 0.571428571429 | KGD4 OGDH OGDHL DLST | tricarboxylic acid cycle |
| GO:0018335 | 1.34540429244e-05 | 0.428571428571 | OGDH DLD DLST | protein succinylation |
| GO:0106077 | 1.34540429244e-05 | 0.428571428571 | OGDH DLD DLST | histone succinylation |
| REAC:R-HSA-71403 | 1.72785870928e-05 | 0.428571428571 | OGDH DLD DLST | Citric acid cycle (TCA cycle) |
| GO:1990204 | 2.50587434005e-05 | 0.714285714286 | KGD4 DLST OGDH OGDHL DLD | oxidoreductase complex |
| REAC:R-HSA-389661 | 2.98557123546e-05 | 0.428571428571 | OGDH DLD DLST | Glyoxylate metabolism and glycine degradation |
| GO:0016903 | 8.36681933501e-05 | 0.571428571429 | KGD4 OGDH OGDHL DLD | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| WP:WP5352 | 9.79338267472e-05 | 0.428571428571 | DLST OGDHL DLD | 10q11 21q11 23 copy number variation syndrome |
| GO:0016624 | 0.0001882019462 | 0.428571428571 | KGD4 OGDHL OGDH | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| REAC:R-HSA-71406 | 0.000285286159018 | 0.428571428571 | OGDH DLD DLST | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP3925 | 0.000550836976424 | 0.428571428571 | OGDH DLD DLST | Amino acid metabolism |
| GO:0043648 | 0.000579396940492 | 0.571428571429 | KGD4 OGDH OGDHL DLST | dicarboxylic acid metabolic process |
| WP:WP4932 | 0.000854290239056 | 0.428571428571 | OGDH DLD DLST | 7q11 23 copy number variation syndrome |
| KEGG:00380 | 0.00538080615206 | 0.285714285714 | DLD DLST | Tryptophan metabolism |
| HPA:0570812 | 0.00711264659889 | 0.857142857143 | DLD OGDH PAGE2B KGD4 DLST OGDHL | testis; spermatogonia cells[>=Medium] |
| REAC:R-HSA-1428517 | 0.00995795730546 | 0.428571428571 | OGDH DLD DLST | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0012401 | 0.0129659395038 | 0.285714285714 | OGDH DLD | Abnormal urine alpha-ketoglutarate concentration |
| HPA:0090183 | 0.014905435517 | 0.571428571429 | KGD4 OGDH OGDHL DLD | cerebellum; cells in granular layer[High] |
| HPA:0090163 | 0.0150403731159 | 0.714285714286 | KGD4 DLST OGDH OGDHL DLD | cerebellum; Purkinje cells[High] |
| GO:0005759 | 0.0156049166687 | 0.714285714286 | KGD4 DLST OGDH OGDHL DLD | mitochondrial matrix |
| HPA:0360053 | 0.01605051393 | 0.714285714286 | KGD4 DLST OGDH OGDHL DLD | parathyroid gland; glandular cells[High] |
| KEGG:00310 | 0.0167496959508 | 0.285714285714 | DLD DLST | Lysine degradation |
| GO:0009060 | 0.0177319694674 | 0.571428571429 | KGD4 OGDH OGDHL DLST | aerobic respiration |
| HPA:0570811 | 0.0191101015746 | 0.857142857143 | DLD OGDH PAGE2B KGD4 DLST OGDHL | testis; spermatogonia cells[>=Low] |
| GO:0045333 | 0.0293914725345 | 0.571428571429 | KGD4 OGDH OGDHL DLST | cellular respiration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.658 |
mutually_exclusive (Q9ULD0)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| OGDHL | DLD | 1.0 | 0.332 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| OGDH | KGD4 | 0.999 | 0.512 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| KGD4 | DLST | 0.999 | 0.336 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| OGDHL | DLST | 0.999 | 0.74 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DLD | DLST | 0.998 | 0.736 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM treiber_WMM | |
| DLD | KGD4 | 0.998 | 0.346 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| OGDHL | OGDH | 0.998 | 0.966 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGDHL | KGD4 | 0.997 | 0.53 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DLD | OGDH | 0.995 | 0.478 |
mutually_exclusive (Q9ULD0)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| TCAIM | DLD | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| OGDHL | PAGE2B | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DBT | KGD4 | 0.979 | 0.152 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DBT | DLST | 0.977 | 0.27 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM | |
| DBT | DLD | 0.965 | 0.302 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| TCAIM | DLST | 0.965 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| OGDHL | TCAIM | 0.956 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TCAIM | KGD4 | 0.936 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TCAIM | OGDH | 0.934 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PAGE2B | DLST | 0.704 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DBT | OGDH | 0.477 | 0.288 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| PAGE2B | DLD | 0.319 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PAGE2B | KGD4 | 0.159 | bioplex3_WMM WMM_only | ||
| PAGE2B | OGDH | 0.11 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DBT | TCAIM | 0.095 | bioplex_WMM bioplex3_WMM WMM_only | ||
| OGDHL | DBT | 0.07 | 0.196 | bioplex_WMM bioplex3_WMM WMM_only | |
| PAGE2B | TCAIM | 0.055 | bioplex3_WMM WMM_only |
Related Complexes