hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10712.1
Complex Portal: CPX-24005
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GDF10 | Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP) | 5 | UniProt NCBI |
| FBN1 | Fibrillin-1 [Cleaved into: Asprosin] | 5 | UniProt NCBI |
| LRP1 | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] | 5 | UniProt NCBI |
| ZFP41 | Zinc finger protein 41 homolog (Zfp-41) | 4 | UniProt NCBI |
| LRP1B | Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) | 5 | UniProt NCBI |
| VLDLR | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | 5 | UniProt NCBI |
| LRPAP1 | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | 5 | UniProt NCBI |
| LRP2 | Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) | 5 | UniProt NCBI |
| ST8SIA2 | Alpha-2,8-sialyltransferase 8B (EC 2.4.3.-) (Sialyltransferase 8B) (SIAT8-B) (Sialyltransferase St8Sia II) (ST8SiaII) (Sialyltransferase X) (STX) | 5 | UniProt NCBI |
| LRP8 | Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) | 5 | UniProt NCBI |
| LDLR | Low-density lipoprotein receptor (LDL receptor) | 5 | UniProt NCBI |
| LRP4 | Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005041 | 1.02319673802e-11 | 0.5 | LRP1 LDLR VLDLR LRP2 LRP1B LRP8 | low-density lipoprotein particle receptor activity |
| GO:0030228 | 2.72660305059e-11 | 0.5 | LRP1 LDLR VLDLR LRP2 LRP1B LRP8 | lipoprotein particle receptor activity |
| GO:0038024 | 2.37989266664e-08 | 0.5 | LRP1 LDLR VLDLR LRP2 LRP1B LRP8 | cargo receptor activity |
| KEGG:04979 | 1.34905656577e-06 | 0.333333333333 | LRP2 LRP1 LDLR LRPAP1 | Cholesterol metabolism |
| GO:0097242 | 1.42069743999e-06 | 0.416666666667 | LRP2 LRP1 LRP4 LDLR LRPAP1 | amyloid-beta clearance |
| REAC:R-HSA-975634 | 6.36789385978e-06 | 0.333333333333 | LRP1 LDLR LRP8 LRP2 | Retinoid metabolism and transport |
| WP:WP5110 | 8.12215593207e-06 | 0.25 | LRP1 LDLR VLDLR | Familial hyperlipidemia type 3 |
| REAC:R-HSA-6806667 | 8.58767993835e-06 | 0.333333333333 | LRP1 LDLR LRP8 LRP2 | Metabolism of fat-soluble vitamins |
| GO:0030229 | 2.11464090368e-05 | 0.25 | VLDLR LDLR LRP8 | very-low-density lipoprotein particle receptor activity |
| GO:1905167 | 2.11464090368e-05 | 0.25 | LRP1 LDLR LRP2 | positive regulation of lysosomal protein catabolic process |
| REAC:R-HSA-2187338 | 9.77463142248e-05 | 0.333333333333 | LRP1 LDLR LRP8 LRP2 | Visual phototransduction |
| GO:0006898 | 0.000193162285739 | 0.5 | LRP1 LDLR VLDLR LRP2 LRP1B LRPAP1 | receptor-mediated endocytosis |
| GO:1904352 | 0.000211268761872 | 0.25 | LRP1 LDLR LRP2 | positive regulation of protein catabolic process in the vacuole |
| GO:1905165 | 0.000738757615619 | 0.25 | LRP1 LDLR LRP2 | regulation of lysosomal protein catabolic process |
| GO:0006897 | 0.000951109707155 | 0.583333333333 | LRP1 LDLR VLDLR LRP2 LRP1B LRP8 LRPAP1 | endocytosis |
| GO:0150094 | 0.00118146610329 | 0.25 | LRP1 LDLR LRP4 | amyloid-beta clearance by cellular catabolic process |
| REAC:R-HSA-196854 | 0.00161220178935 | 0.333333333333 | LRP1 LDLR LRP8 LRP2 | Metabolism of vitamins and cofactors |
| WP:WP5304 | 0.00173112344393 | 0.25 | LRP1 LDLR LRPAP1 | Cholesterol metabolism |
| GO:1904350 | 0.00177138039123 | 0.25 | LRP1 LDLR LRP2 | regulation of protein catabolic process in the vacuole |
| GO:0043235 | 0.00200835622949 | 0.5 | LRP1 LDLR VLDLR LRP2 LRP1B LRP8 | receptor complex |
| HP:0007800 | 0.00385913235323 | 0.166666666667 | LRPAP1 FBN1 | Increased axial length of the globe |
| GO:1905146 | 0.00463290208809 | 0.25 | LRP1 LDLR LRP2 | lysosomal protein catabolic process |
| GO:0034185 | 0.00463290208809 | 0.25 | LRP1 LRP8 VLDLR | apolipoprotein binding |
| WP:WP5112 | 0.00474345148572 | 0.166666666667 | LRP1 LDLR | Familial hyperlipidemia type 5 |
| REAC:R-HSA-9709957 | 0.00490260156577 | 0.333333333333 | LRP1 LDLR LRP8 LRP2 | Sensory Perception |
| GO:0098657 | 0.00606973590453 | 0.583333333333 | LRP1 LDLR VLDLR LRP2 LRP1B LRP8 LRPAP1 | import into cell |
| WP:WP5108 | 0.00753607712322 | 0.166666666667 | LRP1 LDLR | Familial hyperlipidemia type 1 |
| GO:0045056 | 0.00956840807496 | 0.25 | LRP2 LRP1 LRPAP1 | transcytosis |
| WP:WP5111 | 0.00975211067197 | 0.166666666667 | LRP1 LDLR | Familial hyperlipidemia type 4 |
| GO:0007039 | 0.0117710605412 | 0.25 | LRP1 LDLR LRP2 | protein catabolic process in the vacuole |
| WP:WP430 | 0.0165265007402 | 0.166666666667 | LRP1 LDLR | Statin inhibition of cholesterol production |
| WP:WP5323 | 0.0289539561012 | 0.166666666667 | LRP1 LDLR | Fatty Acids and Lipoproteins Transport in Hepatocytes |
| GO:0038025 | 0.0309012475255 | 0.166666666667 | VLDLR LRP8 | reelin receptor activity |
| HP:0011003 | 0.031142061866 | 0.25 | LRPAP1 FBN1 LRP2 | High myopia |
| CORUM:7535 | 0.0499436884912 | 0.0833333333333 | LRP1 | CD44-LRP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRP1B | LRPAP1 | 0.995 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRP2 | LRPAP1 | 0.99 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRPAP1 | LRP4 | 0.988 | 0.064 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZFP41 | FBN1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZFP41 | LRP4 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZFP41 | LRP1B | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRP8 | LRPAP1 | 0.979 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZFP41 | LDLR | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| VLDLR | LRPAP1 | 0.966 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRPAP1 | LRP1 | 0.96 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRP4 | LDLR | 0.96 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| GDF10 | LRP4 | 0.958 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRPAP1 | LDLR | 0.956 | 0.132 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ST8SIA2 | LDLR | 0.952 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZFP41 | LRP1 | 0.925 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZFP41 | LRP2 | 0.908 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRP8 | LDLR | 0.783 | 0.092 |
mutually_exclusive (P30533)
|
bioplex_WMM bioplex3_WMM WMM_only |
| LRP1B | LRP1 | 0.778 | 0.082 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZFP41 | LRPAP1 | 0.729 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FBN1 | LRP1B | 0.699 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP1B | LRP2 | 0.673 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBN1 | LRP1 | 0.662 | 0.242 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP1B | LDLR | 0.619 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBN1 | LRP4 | 0.581 | 0.33 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| LRP2 | LRP1 | 0.575 | 0.254 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBN1 | LDLR | 0.565 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBN1 | LRP2 | 0.556 | 0.266 | bioplex_WMM bioplex3_WMM WMM_only | |
| VLDLR | LDLR | 0.528 | 0.094 |
mutually_exclusive (P30533)
|
bioplex_WMM bioplex3_WMM WMM_only |
| LRP1 | LRP4 | 0.523 | 0.25 | bioplex_WMM bioplex3_WMM WMM_only | |
| VLDLR | LRP2 | 0.497 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP2 | LDLR | 0.481 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP1B | LRP4 | 0.461 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP2 | LRP4 | 0.254 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBN1 | VLDLR | 0.237 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP1 | LDLR | 0.216 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| VLDLR | LRP4 | 0.212 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | LRP4 | 0.196 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| VLDLR | LRP1B | 0.194 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | LRP1B | 0.19 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | VLDLR | 0.172 | 0.082 |
mutually_exclusive (P30533)
|
bioplex_WMM bioplex3_WMM WMM_only |
| VLDLR | LRP1 | 0.117 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | LRP1 | 0.111 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBN1 | LRPAP1 | 0.076 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | LRP2 | 0.066 | 0.086 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| LRP1 | GDF10 | 0.016 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRPAP1 | GDF10 | 0.006 |
mutually_exclusive (O75096)
|
bioplex3_HEK293 bioplex () |
Related Complexes