hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10717.1
Complex Portal: CPX-14115
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C16orf96 | Uncharacterized protein C16orf96 | 2 | UniProt NCBI |
| OR6Q1 | Olfactory receptor 6Q1 (Olfactory receptor OR11-226) | 3 | UniProt NCBI |
| SOS2 | Son of sevenless homolog 2 (SOS-2) | 5 | UniProt NCBI |
| ERRFI1 | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | 5 | UniProt NCBI |
| ARHGEF35 | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | 2 | UniProt NCBI |
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | 5 | UniProt NCBI |
| ARHGEF5 | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | 5 | UniProt NCBI |
| GLS2 | Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase) | 5 | UniProt NCBI |
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 5 | UniProt NCBI |
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | 3 | UniProt NCBI |
| SHC1 | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | 5 | UniProt NCBI |
| GAREM1 | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-193648 | 0.000997590822835 | 0.272727272727 | ARHGEF35 SOS2 ARHGEF5 | NRAGE signals death through JNK |
| REAC:R-HSA-204998 | 0.00235166852176 | 0.272727272727 | ARHGEF35 SOS2 ARHGEF5 | Cell death signalling via NRAGE, NRIF and NADE |
| REAC:R-HSA-416482 | 0.00303340299354 | 0.272727272727 | ARHGEF35 SOS2 ARHGEF5 | G alpha (12/13) signalling events |
| WP:WP4928 | 0.00486811003538 | 0.181818181818 | SOS2 GAREM2 | MAPK pathway in congenital thyroid cancer |
| REAC:R-HSA-193704 | 0.00517368811151 | 0.272727272727 | ARHGEF35 SOS2 ARHGEF5 | p75 NTR receptor-mediated signalling |
| KEGG:05206 | 0.00806298167438 | 0.272727272727 | GLS2 SOS2 GRB2 | MicroRNAs in cancer |
| REAC:R-HSA-8983432 | 0.0103602481019 | 0.181818181818 | GRB2 SOS2 | Interleukin-15 signaling |
| WP:WP437 | 0.0152265095116 | 0.272727272727 | ERRFI1 SOS2 GRB2 | EGF EGFR signaling pathway |
| WP:WP422 | 0.0186770164082 | 0.181818181818 | GRB2 SOS2 | MAPK cascade |
| REAC:R-HSA-73887 | 0.0260326909568 | 0.272727272727 | ARHGEF35 SOS2 ARHGEF5 | Death Receptor Signaling |
| KEGG:05213 | 0.0340997800558 | 0.181818181818 | GRB2 SOS2 | Endometrial cancer |
| KEGG:04664 | 0.0354224763485 | 0.181818181818 | GRB2 SOS2 | Fc epsilon RI signaling pathway |
| WP:WP4535 | 0.0372386402869 | 0.181818181818 | GRB2 SOS2 | Envelope proteins and their potential roles in EDMD physiopathology |
| KEGG:05221 | 0.0438742392764 | 0.181818181818 | GRB2 SOS2 | Acute myeloid leukemia |
| KEGG:04917 | 0.0484301779192 | 0.181818181818 | GRB2 SOS2 | Prolactin signaling pathway |
| CORUM:2540 | 0.049976851631 | 0.0909090909091 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| CORUM:2892 | 0.049976851631 | 0.0909090909091 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:2895 | 0.049976851631 | 0.0909090909091 | GRB2 | SHC-GRB2 complex |
| CORUM:3096 | 0.049976851631 | 0.0909090909091 | GRB2 | ITGA6-ITGB4-SHC1-GRB2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| SOS2 | GRB2 | 1.0 | 0.192 | |
| GRB2 | GAREM1 | 0.999 | ||
| GAREM2 | GAREM1 | 0.998 | ||
| RFFL | SHC1 | 0.998 | ||
| ERRFI1 | GRB2 | 0.998 | 0.202 |
structurally_consistent (dimer)
|
| GAREM1 | OR6Q1 | 0.997 | ||
| ARHGEF35 | ARHGEF5 | 0.994 | ||
| SHC1 | GAREM1 | 0.988 | ||
| GRB2 | GAREM2 | 0.985 | ||
| SHC1 | GRB2 | 0.976 | ||
| GLS2 | GRB2 | 0.974 | 0.2 | |
| C16orf96 | GRB2 | 0.968 | ||
| ARHGEF35 | GRB2 | 0.965 | ||
| ARHGEF5 | GRB2 | 0.954 | 0.134 | |
| SOS2 | ARHGEF35 | 0.904 | ||
| ERRFI1 | ARHGEF35 | 0.904 | ||
| GAREM2 | OR6Q1 | 0.902 | ||
| SHC1 | OR6Q1 | 0.892 | ||
| SOS2 | ARHGEF5 | 0.869 | 0.092 | |
| SOS2 | ERRFI1 | 0.844 | 0.09 | |
| SHC1 | GAREM2 | 0.796 | ||
| SHC1 | ARHGEF35 | 0.715 | ||
| SHC1 | SOS2 | 0.675 | ||
| ERRFI1 | ARHGEF5 | 0.626 | 0.15 | |
| C16orf96 | SOS2 | 0.557 | ||
| C16orf96 | GAREM2 | 0.557 | ||
| C16orf96 | ERRFI1 | 0.557 | ||
| C16orf96 | GAREM1 | 0.543 | ||
| SOS2 | GAREM2 | 0.487 | ||
| ERRFI1 | GAREM2 | 0.487 | ||
| GRB2 | OR6Q1 | 0.377 | ||
| SHC1 | ERRFI1 | 0.343 | ||
| SHC1 | ARHGEF5 | 0.331 | ||
| ERRFI1 | GAREM1 | 0.33 | ||
| SOS2 | GAREM1 | 0.303 | ||
| C16orf96 | ARHGEF35 | 0.214 | ||
| ARHGEF35 | GAREM2 | 0.214 | ||
| ARHGEF5 | GAREM2 | 0.214 | ||
| C16orf96 | ARHGEF5 | 0.214 | ||
| ARHGEF35 | GAREM1 | 0.131 | ||
| SHC1 | C16orf96 | 0.131 | ||
| C16orf96 | GLS2 | 0.122 | ||
| GLS2 | GAREM2 | 0.122 | ||
| SOS2 | GLS2 | 0.11 | 0.154 | |
| GLS2 | GAREM1 | 0.11 | ||
| ERRFI1 | GLS2 | 0.11 | 0.066 | |
| ARHGEF5 | GAREM1 | 0.1 | ||
| RFFL | GRB2 | 0.059 | 0.126 | |
| ARHGEF35 | GLS2 | 0.015 | ||
| ARHGEF5 | GLS2 | 0.015 | 0.104 | |
| SHC1 | GLS2 | 0.013 |
Related Complexes