hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10727.1
Complex Portal: CPX-11028
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF31 | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | 5 | UniProt NCBI |
| SHARPIN | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | 5 | UniProt NCBI |
| RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | 5 | UniProt NCBI |
| LIPN | Lipase member N (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 4) | 5 | UniProt NCBI |
| LIPF | Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6178 | 2.80233355908e-09 | 0.6 | RBCK1 RNF31 SHARPIN | LUBAC complex |
| GO:0071797 | 9.61200410764e-07 | 0.6 | RBCK1 RNF31 SHARPIN | LUBAC complex |
| REAC:R-HSA-5357786 | 6.30285051125e-06 | 0.6 | RBCK1 RNF31 SHARPIN | TNFR1-induced proapoptotic signaling |
| GO:0097039 | 9.61003071434e-06 | 0.6 | RBCK1 RNF31 SHARPIN | protein linear polyubiquitination |
| REAC:R-HSA-5357956 | 1.54330255969e-05 | 0.6 | RBCK1 RNF31 SHARPIN | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-5357905 | 4.1157848778e-05 | 0.6 | RBCK1 RNF31 SHARPIN | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 7.27326653199e-05 | 0.6 | RBCK1 RNF31 SHARPIN | TNF signaling |
| KEGG:04217 | 0.00038585597196 | 0.6 | RBCK1 RNF31 SHARPIN | Necroptosis |
| KEGG:04621 | 0.000467209213785 | 0.6 | RBCK1 RNF31 SHARPIN | NOD-like receptor signaling pathway |
| REAC:R-HSA-73887 | 0.00102719141084 | 0.6 | RBCK1 RNF31 SHARPIN | Death Receptor Signaling |
| CORUM:6344 | 0.00124012622854 | 0.4 | RBCK1 RNF31 | TNF-R1-associated signaling complex |
| KEGG:05131 | 0.00175429069912 | 0.6 | RBCK1 RNF31 SHARPIN | Shigellosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RBCK1 | RNF31 | 1.0 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RNF31 | SHARPIN | 1.0 | 0.288 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RBCK1 | SHARPIN | 0.999 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LIPN | LIPF | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RNF31 | LIPF | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIPF | SHARPIN | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIPN | SHARPIN | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RNF31 | LIPN | 0.143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes