hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10730.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | 5 | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | 5 | UniProt NCBI |
| HLTF | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | 5 | UniProt NCBI |
| CHD1L | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | 5 | UniProt NCBI |
| XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 5 | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | 5 | UniProt NCBI |
| MACROD1 | ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-) | 5 | UniProt NCBI |
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | 5 | UniProt NCBI |
| APLF | Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | 5 | UniProt NCBI |
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | 5 | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5696399 | 6.14721256727e-08 | 0.625 | PARP2 XPC CHD1L LIG3 PARP1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 2.34992048859e-07 | 0.625 | PARP2 XPC CHD1L LIG3 PARP1 | Nucleotide Excision Repair |
| REAC:R-HSA-5696395 | 8.70007386216e-07 | 0.5 | PARP2 XPC CHD1L PARP1 | Formation of Incision Complex in GG-NER |
| GO:0006974 | 1.63460050162e-06 | 1.0 | PARP2 LIG3 MACROD1 HLTF XPC PARP1 APLF CHD1L | DNA damage response |
| WP:WP5114 | 3.60336134753e-06 | 0.5 | XPC CHD1L LIG3 PARP1 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-5685939 | 3.77160472982e-06 | 0.375 | PARP1 LIG3 PARP2 | HDR through MMEJ (alt-NHEJ) |
| GO:0006281 | 1.62739280972e-05 | 0.875 | PARP2 LIG3 PARP1 HLTF XPC APLF CHD1L | DNA repair |
| WP:WP4946 | 2.11293894781e-05 | 0.5 | PARP2 XPC LIG3 PARP1 | DNA repair pathways full network |
| CORUM:7352 | 2.39226645298e-05 | 0.25 | PARP1 LIG3 | PARP1-LIG3 complex |
| WP:WP4752 | 3.96037455585e-05 | 0.375 | PARP1 LIG3 PARP2 | Base excision repair |
| REAC:R-HSA-73894 | 4.40742349863e-05 | 0.625 | PARP2 XPC CHD1L LIG3 PARP1 | DNA Repair |
| KEGG:03410 | 6.50981793488e-05 | 0.375 | PARP1 LIG3 PARP2 | Base excision repair |
| GO:0160002 | 0.00010757157937 | 0.375 | CHD1L APLF PARP2 | ADP-D-ribose modification-dependent protein binding |
| REAC:R-HSA-73933 | 0.000148687552241 | 0.375 | PARP1 LIG3 PARP2 | Resolution of Abasic Sites (AP sites) |
| GO:0033554 | 0.000180586151088 | 1.0 | PARP2 LIG3 MACROD1 HLTF XPC PARP1 APLF CHD1L | cellular response to stress |
| REAC:R-HSA-5696394 | 0.000191499085287 | 0.375 | PARP2 XPC PARP1 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696400 | 0.000241797870321 | 0.375 | PARP2 PARP1 CHD1L | Dual Incision in GG-NER |
| GO:0006259 | 0.000396845715691 | 0.875 | PARP2 LIG3 PARP1 HLTF XPC APLF CHD1L | DNA metabolic process |
| REAC:R-HSA-110362 | 0.00155943355885 | 0.25 | PARP1 PARP2 | POLB-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-73884 | 0.00158030541683 | 0.375 | PARP1 LIG3 PARP2 | Base Excision Repair |
| WP:WP3645 | 0.00364416819939 | 0.25 | PARP1 PARP2 | NAD biosynthetic pathways |
| GO:0090734 | 0.00766061600114 | 0.5 | PARP2 PARP1 APLF CHD1L | site of DNA damage |
| REAC:R-HSA-5693538 | 0.00775010993696 | 0.375 | PARP1 LIG3 PARP2 | Homology Directed Repair |
| GO:0140805 | 0.0131096201623 | 0.25 | PARP1 PARP2 | NAD+-protein-serine ADP-ribosyltransferase activity |
| REAC:R-HSA-5693532 | 0.0141950226766 | 0.375 | PARP1 LIG3 PARP2 | DNA Double-Strand Break Repair |
| REAC:R-HSA-110373 | 0.0166306183768 | 0.25 | PARP1 PARP2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| GO:0006950 | 0.0341601246885 | 1.0 | PARP2 LIG3 MACROD1 HLTF XPC PARP1 APLF CHD1L | response to stress |
| GO:0030592 | 0.0393180950424 | 0.25 | PARP1 PARP2 | DNA ADP-ribosylation |
| GO:0140294 | 0.0393180950424 | 0.25 | PARP1 PARP2 | NAD DNA ADP-ribosyltransferase activity |
| HPA:0301371 | 0.0444980725937 | 0.625 | PARP2 XPC CHD1L LIG3 PARP1 | lung; alveolar cells type II[>=Low] |
| CORUM:212 | 0.0499436884912 | 0.125 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:363 | 0.0499436884912 | 0.125 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 0.0499436884912 | 0.125 | LIG3 | DNA ligase III-XRCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| XRCC6 | XRCC5 | 1.0 | 0.96 |
| XRCC5 | APLF | 0.998 | |
| XRCC6 | APLF | 0.998 | |
| XRCC6 | RPA2 | 0.997 | 0.456 |
| APLF | XPC | 0.997 | |
| APLF | PARP1 | 0.997 | |
| APLF | PARP2 | 0.997 | |
| APLF | LIG3 | 0.996 | |
| XPC | RPA2 | 0.995 | 0.14 |
| XRCC6 | PARP1 | 0.995 | 0.55 |
| APLF | RPA2 | 0.995 | |
| APLF | HLTF | 0.994 | |
| XPC | PARP2 | 0.993 | 0.032 |
| HLTF | CHD1L | 0.993 | 0.09 |
| XPC | PARP1 | 0.992 | 0.363073394495 |
| LIG3 | PARP2 | 0.991 | 0.076 |
| MACROD1 | PARP1 | 0.991 | 0.166 |
| XRCC5 | RPA2 | 0.99 | 0.424 |
| LIG3 | RPA2 | 0.989 | 0.106 |
| XPC | CHD1L | 0.988 | 0.024 |
| RPA2 | PARP1 | 0.985 | 0.424 |
| HLTF | XPC | 0.984 | 0.032 |
| RPA2 | PARP2 | 0.983 | 0.048 |
| LIG3 | PARP1 | 0.982 | 0.53 |
| LIG3 | XPC | 0.981 | 0.164 |
| MACROD1 | RPA2 | 0.978 | 0.026 |
| HLTF | RPA2 | 0.977 | 0.07 |
| LIG3 | HLTF | 0.973 | 0.1 |
| XRCC6 | PARP2 | 0.97 | 0.206 |
| PARP2 | CHD1L | 0.966 | 0.054 |
| XRCC6 | CHD1L | 0.966 | 0.198 |
| XRCC5 | CHD1L | 0.965 | 0.264 |
| MACROD1 | XPC | 0.964 | 0.022 |
| HLTF | PARP1 | 0.963 | 0.482857142857 |
| XRCC6 | LIG3 | 0.96 | 0.338 |
| CHD1L | PARP1 | 0.958 | 0.470310125952 |
| XRCC5 | LIG3 | 0.955 | 0.306 |
| MACROD1 | PARP2 | 0.95 | 0.034 |
| XRCC6 | XPC | 0.932 | 0.314 |
| LIG3 | CHD1L | 0.92 | 0.094 |
| XRCC5 | PARP1 | 0.905 | 0.672 |
| RPA2 | CHD1L | 0.9 | 0.082 |
| XRCC5 | XPC | 0.853 | 0.292 |
| XRCC5 | HLTF | 0.823 | 0.114 |
| APLF | CHD1L | 0.818 | |
| XRCC5 | MACROD1 | 0.779 | 0.186 |
| HLTF | PARP2 | 0.654 | 0.086 |
| XRCC6 | MACROD1 | 0.63 | 0.2 |
| XRCC6 | HLTF | 0.561 | 0.106 |
| XRCC5 | PARP2 | 0.538 | 0.198 |
| PARP2 | PARP1 | 0.423 | 0.307277777778 |
| LIG3 | MACROD1 | 0.304 | 0.036 |
| HLTF | MACROD1 | 0.067 | 0.036 |
Related Complexes