hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10735.1
Complex Portal: CPX-12243
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CSTB | Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B) | 5 | UniProt NCBI |
| CTSH | Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] | 5 | UniProt NCBI |
| CTSB | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | 5 | UniProt NCBI |
| CST3 | Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin) | 5 | UniProt NCBI |
| CTSL | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097067 | 3.362820138e-05 | 0.6 | CTSB CTSH CTSL | cellular response to thyroid hormone stimulus |
| HPA:0271143 | 3.99934974131e-05 | 0.8 | CTSB CTSL CTSH CST3 | kidney; proximal tubules (cell body)[High] |
| GO:0097066 | 5.37995977657e-05 | 0.6 | CTSB CTSH CTSL | response to thyroid hormone |
| HPA:0461451 | 0.00013002085323 | 0.8 | CTSB CST3 CSTB CTSH | skin 1; hair follicles[>=Low] |
| REAC:R-HSA-168249 | 0.0001330112025 | 1.0 | CTSB CTSL CST3 CSTB CTSH | Innate Immune System |
| KEGG:04210 | 0.000258943315877 | 0.6 | CTSB CTSH CTSL | Apoptosis |
| KEGG:04142 | 0.000278939673238 | 0.6 | CTSB CTSH CTSL | Lysosome |
| HPA:0271142 | 0.000562683947642 | 0.8 | CTSB CTSL CTSH CST3 | kidney; proximal tubules (cell body)[>=Medium] |
| REAC:R-HSA-6798695 | 0.000580611083989 | 0.8 | CTSB CST3 CSTB CTSH | Neutrophil degranulation |
| REAC:R-HSA-2132295 | 0.000802337674321 | 0.6 | CTSB CTSH CTSL | MHC class II antigen presentation |
| REAC:R-HSA-1679131 | 0.000835043279679 | 0.4 | CTSB CTSL | Trafficking and processing of endosomal TLR |
| GO:1904813 | 0.000969335687232 | 0.8 | CTSB CST3 CSTB CTSH | ficolin-1-rich granule lumen |
| HPA:0271141 | 0.0014706004202 | 0.8 | CTSB CTSL CTSH CST3 | kidney; proximal tubules (cell body)[>=Low] |
| GO:0061134 | 0.00206012733421 | 0.8 | CST3 CTSL CSTB CTSH | peptidase regulator activity |
| GO:0031904 | 0.00249322401434 | 0.6 | CTSB CTSH CTSL | endosome lumen |
| GO:0030574 | 0.00280458876292 | 0.6 | CTSB CTSL CST3 | collagen catabolic process |
| REAC:R-HSA-168256 | 0.0033091856911 | 1.0 | CTSB CTSL CST3 CSTB CTSH | Immune System |
| GO:0101002 | 0.00378855826806 | 0.8 | CTSB CST3 CSTB CTSH | ficolin-1-rich granule |
| KEGG:04612 | 0.00825154536734 | 0.4 | CTSB CTSL | Antigen processing and presentation |
| GO:0030141 | 0.00857319991583 | 1.0 | CTSB CTSL CST3 CSTB CTSH | secretory granule |
| GO:0060309 | 0.0140440992017 | 0.4 | CST3 CTSL | elastin catabolic process |
| HP:0007550 | 0.0147628051395 | 0.6 | CTSB CSTB CTSH | Hypohidrosis or hyperhidrosis |
| REAC:R-HSA-2022090 | 0.0163316506439 | 0.4 | CTSB CTSL | Assembly of collagen fibrils and other multimeric structures |
| HP:0025276 | 0.0164434381168 | 0.6 | CTSB CSTB CTSH | Abnormality of skin adnexa physiology |
| GO:0099503 | 0.0172206898247 | 1.0 | CTSB CTSL CST3 CSTB CTSH | secretory vesicle |
| REAC:R-HSA-1442490 | 0.0177620315324 | 0.4 | CTSB CTSL | Collagen degradation |
| GO:1904724 | 0.0224016609185 | 0.6 | CST3 CSTB CTSH | tertiary granule lumen |
| GO:0032963 | 0.0237169649094 | 0.6 | CTSB CTSL CST3 | collagen metabolic process |
| REAC:R-HSA-1474290 | 0.0384836492499 | 0.4 | CTSB CTSL | Collagen formation |
| WP:WP4217 | 0.0386238148414 | 0.4 | CTSB CTSL | Ebola virus infection in host |
| HPA:0271121 | 0.0396313993381 | 0.6 | CTSB CTSH CST3 | kidney; collecting ducts[>=Low] |
| GO:0062023 | 0.043388817269 | 0.8 | CTSB CTSL CSTB CTSH | collagen-containing extracellular matrix |
| GO:0036021 | 0.0468008499735 | 0.4 | CTSB CTSL | endolysosome lumen |
| GO:0051541 | 0.0468008499735 | 0.4 | CST3 CTSL | elastin metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CTSL | CST3 | 0.998 | 0.104 |
mutually_exclusive (P04080)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction |
| CTSB | CST3 | 0.994 | 0.330580645161 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| CST3 | CTSH | 0.989 | 0.224 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CTSL | CTSH | 0.969 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CSTB | CTSH | 0.951 | 0.134 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CST3 | CSTB | 0.903 | 0.192 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CTSL | CTSB | 0.726 | 0.172424242424 |
mutually_exclusive (P04080)
structurally_consistent (dimer) |
Guru bioplex3_WMM fraction |
| CTSL | CSTB | 0.355 | 0.086 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex3_WMM |
| CTSB | CTSH | 0.14 | 0.21425 |
structurally_consistent (P01034)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CTSB | CSTB | 0.068 | 0.088 |
mutually_exclusive (P07711)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
Related Complexes