hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10741.1
Complex Portal: CPX-11247
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THNSL1 | Threonine synthase-like 1 (TSH1) | 2 | UniProt NCBI |
| ISCA2 | Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) | 5 | UniProt NCBI |
| NPPB | Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)] | 5 | UniProt NCBI |
| TEPSIN | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | 5 | UniProt NCBI |
| NUDT6 | Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG) | 5 | UniProt NCBI |
| RAB37 | Ras-related protein Rab-37 | 5 | UniProt NCBI |
| ISCA1 | Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1362409 | 0.000928329318648 | 0.333333333333 | ISCA2 ISCA1 | Mitochondrial iron-sulfur cluster biogenesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ISCA1 | ISCA2 | 0.996 | 0.064 |
structurally_consistent (Q8IYQ7)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ISCA1 | NPPB | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ISCA1 | TEPSIN | 0.988 | 0.078 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| THNSL1 | ISCA1 | 0.987 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| THNSL1 | NPPB | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ISCA1 | NUDT6 | 0.983 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ISCA2 | RAB37 | 0.97 | 0.112 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| THNSL1 | ISCA2 | 0.956 | 0.034 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TEPSIN | ISCA2 | 0.95 | 0.05 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NUDT6 | TEPSIN | 0.25 | 0.096 | bioplex3_WMM WMM_only | |
| THNSL1 | NUDT6 | 0.102 | 0.106 | bioplex3_WMM WMM_only | |
| THNSL1 | TEPSIN | 0.089 | 0.028 | bioplex3_WMM WMM_only | |
| NUDT6 | ISCA2 | 0.061 | 0.08 | bioplex3_WMM WMM_only | |
| NPPB | ISCA2 | 0.017 | bioplex3_HEK293 WMM_only |
Related Complexes