hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10751.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OPTN | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | 5 | UniProt NCBI |
| NSF | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | 5 | UniProt NCBI |
| TBC1D17 | TBC1 domain family member 17 | 5 | UniProt NCBI |
| STX12 | Syntaxin-12 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8854214 | 0.007571530532 | 0.5 | OPTN TBC1D17 | TBC/RABGAPs |
| KEGG:04137 | 0.0118173906169 | 0.5 | OPTN TBC1D17 | Mitophagy - animal |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | OPTN NSF TBC1D17 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | OPTN NSF TBC1D17 | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NSF | STX12 | 0.979 | 0.37 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| OPTN | STX12 | 0.974 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TBC1D17 | STX12 | 0.973 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TBC1D17 | OPTN | 0.262 | 0.118 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NSF | OPTN | 0.07 | 0.116 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NSF | TBC1D17 | 0.057 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes