hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10753.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZRANB2 | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| NOS1AP | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | 5 | UniProt NCBI |
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4971 | 1.3807096837e-05 | 0.6 | PLCD3 PIP4K2B PIP4K2C | Phosphoinositides metabolism |
| WP:WP5411 | 1.3807096837e-05 | 0.6 | PLCD3 PIP4K2B PIP4K2C | Phosphatidyl inositol phosphate pathway |
| KEGG:00562 | 4.05033588721e-05 | 0.6 | PLCD3 PIP4K2B PIP4K2C | Inositol phosphate metabolism |
| REAC:R-HSA-8847453 | 9.11829675208e-05 | 0.4 | PIP4K2B PIP4K2C | Synthesis of PIPs in the nucleus |
| KEGG:04070 | 9.13984227268e-05 | 0.6 | PLCD3 PIP4K2B PIP4K2C | Phosphatidylinositol signaling system |
| REAC:R-HSA-6811555 | 0.000546723465219 | 0.4 | PIP4K2B PIP4K2C | PI5P Regulates TP53 Acetylation |
| REAC:R-HSA-6804758 | 0.0065872694687 | 0.4 | PIP4K2B PIP4K2C | Regulation of TP53 Activity through Acetylation |
| GO:0016309 | 0.0140440992017 | 0.4 | PIP4K2B PIP4K2C | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 0.0140440992017 | 0.4 | PIP4K2B PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 0.0140440992017 | 0.4 | PIP4K2B PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| REAC:R-HSA-1660499 | 0.0163316506439 | 0.4 | PIP4K2B PIP4K2C | Synthesis of PIPs at the plasma membrane |
| REAC:R-HSA-1483255 | 0.0384836492499 | 0.4 | PIP4K2B PIP4K2C | PI Metabolism |
| REAC:R-HSA-6811558 | 0.0406556405791 | 0.4 | PIP4K2B PIP4K2C | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| WP:WP51 | 0.046989062869 | 0.4 | PIP4K2B PIP4K2C | Regulation of actin cytoskeleton |
| REAC:R-HSA-199418 | 0.0487218825663 | 0.4 | PIP4K2B PIP4K2C | Negative regulation of the PI3K/AKT network |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PLCD3 | PIP4K2C | 0.994 | 0.15 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ZRANB2 | PIP4K2C | 0.99 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| PIP4K2C | NOS1AP | 0.982 | 0.098 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| PIP4K2B | NOS1AP | 0.971 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PIP4K2B | PLCD3 | 0.95 | 0.068 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PLCD3 | NOS1AP | 0.948 | 0.18 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ZRANB2 | PIP4K2B | 0.907 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| ZRANB2 | NOS1AP | 0.306 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| ZRANB2 | PLCD3 | 0.097 | 0.044 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes