hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10767.1
Complex Portal: CPX-21565
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RFLNB | Refilin-B (Regulator of filamin protein B) (RefilinB) | 3 | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | 5 | UniProt NCBI |
| PYCR3 | Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein) | 5 | UniProt NCBI |
| NUDT5 | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | 5 | UniProt NCBI |
| PPAT | Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) | 5 | UniProt NCBI |
| NSUN5 | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | 5 | UniProt NCBI |
| AGBL2 | Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2) | 5 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 3.77160472982e-06 | 0.375 | PYCR2 PYCR1 PYCR3 | Glutamate and glutamine metabolism |
| GO:0004735 | 2.15253635486e-05 | 0.375 | PYCR2 PYCR1 PYCR3 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 2.15253635486e-05 | 0.375 | PYCR2 PYCR1 PYCR3 | L-proline biosynthetic process |
| GO:0006561 | 5.37995977657e-05 | 0.375 | PYCR2 PYCR1 PYCR3 | proline biosynthetic process |
| KEGG:00330 | 6.50981793488e-05 | 0.375 | PYCR2 PYCR1 PYCR3 | Arginine and proline metabolism |
| WP:WP4290 | 8.89415095278e-05 | 0.375 | PYCR2 PPAT PYCR1 | Metabolic reprogramming in colon cancer |
| KEGG:01230 | 0.000251141708404 | 0.375 | PYCR2 PYCR1 PYCR3 | Biosynthesis of amino acids |
| GO:0006560 | 0.00045145282213 | 0.375 | PYCR2 PYCR1 PYCR3 | proline metabolic process |
| GO:0016646 | 0.00195378579303 | 0.375 | PYCR2 PYCR1 PYCR3 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| GO:0009084 | 0.00244160521127 | 0.375 | PYCR2 PYCR1 PYCR3 | glutamine family amino acid biosynthetic process |
| WP:WP497 | 0.00499769201238 | 0.25 | PYCR3 PYCR1 | Urea cycle and metabolism of amino groups |
| GO:0016645 | 0.00519447563198 | 0.375 | PYCR2 PYCR1 PYCR3 | oxidoreductase activity, acting on the CH-NH group of donors |
| KEGG:01100 | 0.0120498549077 | 0.625 | PYCR2 PYCR1 PPAT NUDT5 PYCR3 | Metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.416 |
mutually_exclusive (Q53H96)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| PYCR2 | NUDT5 | 0.999 | 0.1 |
structurally_consistent (P32322)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| AGBL2 | NUDT5 | 0.999 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| PYCR1 | NUDT5 | 0.999 | 0.152 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| PYCR2 | PYCR3 | 0.999 | 0.032 |
mutually_exclusive (P32322)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PYCR1 | PYCR3 | 0.992 | 0.094 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| NUDT5 | PPAT | 0.991 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| RFLNB | NUDT5 | 0.988 | 0.048 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| NSUN5 | PYCR2 | 0.958 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| RFLNB | AGBL2 | 0.939 | bioplex3_WMM WMM_only | ||
| NSUN5 | PYCR1 | 0.934 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| AGBL2 | PPAT | 0.624 | bioplex3_WMM WMM_only | ||
| NUDT5 | PYCR3 | 0.336 | 0.06 |
structurally_consistent (P32322)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PPAT | PYCR3 | 0.17 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| RFLNB | PPAT | 0.151 | 0.028 | bioplex3_WMM youn_WMM WMM_only | |
| PYCR2 | PPAT | 0.075 | 0.078 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NSUN5 | PPAT | 0.074 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| NSUN5 | PYCR3 | 0.054 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only | |
| PYCR1 | PPAT | 0.023 | 0.136 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RFLNB | PYCR3 | 0.006 | 0.044 | youn_WMM WMM_only | |
| RFLNB | PYCR1 | 0.005 | 0.056 | youn_WMM WMM_only | |
| RFLNB | PYCR2 | 0.005 | 0.068 | youn_WMM WMM_only |
Related Complexes