hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10768.1
Complex Portal: CPX-21484
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLAUR | Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87) | 5 | UniProt NCBI |
| NUBPL | Iron-sulfur cluster transfer protein NUBPL (IND1 homolog) (Nucleotide-binding protein-like) (huInd1) | 5 | UniProt NCBI |
| LAMB3 | Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta) | 5 | UniProt NCBI |
| PXDN | Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] | 5 | UniProt NCBI |
| LARGE1 | Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2022090 | 0.0163316506439 | 0.4 | LAMB3 PXDN | Assembly of collagen fibrils and other multimeric structures |
| HP:0000557 | 0.0176485923371 | 0.4 | LARGE1 PXDN | Buphthalmos |
| HP:0007833 | 0.0191806250585 | 0.4 | LARGE1 PXDN | Anterior chamber synechiae |
| REAC:R-HSA-1474290 | 0.0384836492499 | 0.4 | LAMB3 PXDN | Collagen formation |
| HP:0001090 | 0.0472853555832 | 0.4 | LARGE1 PXDN | Abnormally large globe |
| CORUM:7108 | 0.0498708842806 | 0.2 | PLAUR | IGF2R-PLAUR complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PLAUR | LARGE1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PLAUR | PXDN | 0.978 | 0.202 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LAMB3 | PLAUR | 0.97 | 0.048 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NUBPL | PLAUR | 0.966 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LARGE1 | PXDN | 0.325 | bioplex_WMM bioplex3_WMM WMM_only | ||
| LAMB3 | PXDN | 0.206 | 0.346 | bioplex3_WMM WMM_only | |
| NUBPL | LARGE1 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | ||
| LAMB3 | NUBPL | 0.077 | 0.046 | bioplex3_WMM WMM_only | |
| NUBPL | PXDN | 0.046 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| LAMB3 | LARGE1 | 0.038 | bioplex3_WMM WMM_only |
Related Complexes