hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10769.1
Complex Portal: CPX-14200
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | 5 | UniProt NCBI |
| DOCK5 | Dedicator of cytokinesis protein 5 | 5 | UniProt NCBI |
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | 5 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | 5 | UniProt NCBI |
| DOCK2 | Dedicator of cytokinesis protein 2 | 5 | UniProt NCBI |
| AHI1 | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | 5 | UniProt NCBI |
| ELMO3 | Engulfment and cell motility protein 3 | 3 | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | 5 | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | 5 | UniProt NCBI |
| DOCK1 | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013408 | 1.45342522155e-10 | 0.666666666667 | DOCK5 ELMO2 DOCK2 DOCK3 DOCK4 DOCK1 | RHOG GTPase cycle |
| REAC:R-HSA-983231 | 3.87085489485e-06 | 0.555555555556 | DOCK5 DOCK1 DOCK2 DOCK4 DOCK3 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-9013149 | 3.99643412879e-06 | 0.555555555556 | DOCK5 DOCK1 DOCK2 DOCK4 DOCK3 | RAC1 GTPase cycle |
| KEGG:05100 | 4.21678256715e-06 | 0.444444444444 | ELMO2 DOCK1 ELMO1 ELMO3 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-9012999 | 6.87061664629e-06 | 0.666666666667 | DOCK5 ELMO2 DOCK2 DOCK3 DOCK4 DOCK1 | RHO GTPase cycle |
| GO:0005085 | 7.7209120656e-06 | 0.666666666667 | DOCK5 DOCK3 DOCK2 DOCK4 DOCK1 ELMO1 | guanyl-nucleotide exchange factor activity |
| REAC:R-HSA-8849471 | 1.09103559608e-05 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| CORUM:5341 | 2.73623797451e-05 | 0.222222222222 | ELMO1 DOCK2 | ELMO1-DOCK2 complex |
| CORUM:5337 | 2.73623797451e-05 | 0.222222222222 | DOCK1 ELMO1 | ELMO1-DOCK1 complex |
| REAC:R-HSA-9013404 | 2.82551309181e-05 | 0.444444444444 | DOCK3 DOCK1 DOCK2 DOCK4 | RAC2 GTPase cycle |
| CORUM:5342 | 8.20609246787e-05 | 0.222222222222 | DOCK1 ELMO1 | ELMO1-DOCK1-RAC1 complex |
| CORUM:5343 | 8.20609246787e-05 | 0.222222222222 | DOCK1 ELMO1 | ELMO1-DOCK1-CRKII complex |
| REAC:R-HSA-194315 | 0.000111617729477 | 0.666666666667 | DOCK5 ELMO2 DOCK2 DOCK3 DOCK4 DOCK1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00012709299758 | 0.666666666667 | DOCK5 ELMO2 DOCK2 DOCK3 DOCK4 DOCK1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-8848021 | 0.000573226646465 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Signaling by PTK6 |
| REAC:R-HSA-9006927 | 0.000573226646465 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Signaling by Non-Receptor Tyrosine Kinases |
| GO:0060589 | 0.0007519864016 | 0.666666666667 | DOCK5 DOCK3 DOCK2 DOCK4 DOCK1 ELMO1 | nucleoside-triphosphatase regulator activity |
| GO:0030695 | 0.0007519864016 | 0.666666666667 | DOCK5 DOCK3 DOCK2 DOCK4 DOCK1 ELMO1 | GTPase regulator activity |
| REAC:R-HSA-9664422 | 0.000882703573715 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664417 | 0.000882703573715 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Leishmania phagocytosis |
| REAC:R-HSA-9664407 | 0.000882703573715 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Parasite infection |
| REAC:R-HSA-2029482 | 0.00104353727432 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-109582 | 0.0015546138994 | 0.555555555556 | DOCK5 DOCK1 DOCK2 DOCK4 DOCK3 | Hemostasis |
| GO:0031267 | 0.00157804544333 | 0.555555555556 | DOCK5 DOCK1 DOCK2 DOCK4 DOCK3 | small GTPase binding |
| REAC:R-HSA-164944 | 0.00167485737707 | 0.222222222222 | ELMO1 DOCK2 | Nef and signal transduction |
| KEGG:05135 | 0.00194722583522 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Yersinia infection |
| REAC:R-HSA-2029480 | 0.00284454699146 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:0051020 | 0.00311277819429 | 0.555555555556 | DOCK5 DOCK1 DOCK2 DOCK4 DOCK3 | GTPase binding |
| REAC:R-HSA-4420097 | 0.00395224313584 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.00514835022343 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Signaling by VEGF |
| REAC:R-HSA-162582 | 0.0063866282108 | 0.777777777778 | DOCK5 ELMO2 DOCK2 DOCK3 DOCK1 DOCK4 ELMO1 | Signal Transduction |
| GO:0007520 | 0.0106791414882 | 0.333333333333 | DOCK5 DOCK2 DOCK1 | myoblast fusion |
| KEGG:05131 | 0.0146549467572 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Shigellosis |
| REAC:R-HSA-9658195 | 0.0150593300182 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Leishmania infection |
| REAC:R-HSA-9824443 | 0.0150593300182 | 0.333333333333 | ELMO2 ELMO1 DOCK1 | Parasitic Infection Pathways |
| GO:0048870 | 0.0153433897249 | 0.777777777778 | DOCK5 ELMO2 ELMO3 DOCK2 DOCK1 DOCK4 ELMO1 | cell motility |
| GO:1904694 | 0.016855225923 | 0.222222222222 | DOCK5 DOCK4 | negative regulation of vascular associated smooth muscle contraction |
| REAC:R-HSA-9006934 | 0.0199771648526 | 0.444444444444 | DOCK3 DOCK1 ELMO1 ELMO2 | Signaling by Receptor Tyrosine Kinases |
| GO:0000768 | 0.0234426873659 | 0.333333333333 | DOCK5 DOCK2 DOCK1 | syncytium formation by plasma membrane fusion |
| GO:0140253 | 0.0262477173145 | 0.333333333333 | DOCK5 DOCK2 DOCK1 | cell-cell fusion |
| GO:0006949 | 0.0262477173145 | 0.333333333333 | DOCK5 DOCK2 DOCK1 | syncytium formation |
| REAC:R-HSA-164952 | 0.0278157587689 | 0.222222222222 | ELMO1 DOCK2 | The role of Nef in HIV-1 replication and disease pathogenesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ELMO2 | DOCK5 | 1.0 | 0.064 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELMO1 | DOCK5 | 1.0 | 0.114 |
structurally_consistent (Q96JJ3)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELMO1 | ELMO2 | 1.0 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELMO1 | DOCK4 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO1 | DOCK1 | 0.999 | 0.138 |
structurally_consistent (Q96JJ3)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELMO3 | DOCK5 | 0.999 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK1 | 0.999 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ELMO1 | DOCK3 | 0.999 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK3 | 0.999 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOCK4 | ELMO2 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| ELMO2 | DOCK1 | 0.997 | 0.23 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ELMO2 | DOCK3 | 0.997 | 0.156 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| DOCK2 | ELMO3 | 0.993 | 0.112 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ELMO3 | ELMO2 | 0.991 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOCK4 | DOCK3 | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| DOCK1 | DOCK5 | 0.988 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOCK5 | AHI1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ELMO1 | ELMO3 | 0.982 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAC2 | DOCK1 | 0.978 | 0.3 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOCK4 | DOCK1 | 0.976 |
mutually_exclusive (Q92556)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RAC2 | ELMO3 | 0.966 | 0.180711111111 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAC2 | ELMO2 | 0.952 | 0.208 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAC2 | DOCK4 | 0.952 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RAC2 | DOCK5 | 0.942 | 0.21 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOCK4 | DOCK5 | 0.918 |
mutually_exclusive (Q92556)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RAC2 | ELMO1 | 0.916 | 0.24 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOCK3 | DOCK5 | 0.911 | 0.194 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOCK2 | DOCK3 | 0.902 | 0.1 | bioplex3_WMM WMM_only | |
| DOCK1 | DOCK3 | 0.9 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOCK2 | DOCK5 | 0.883 | 0.168 | bioplex3_WMM WMM_only | |
| DOCK2 | DOCK4 | 0.869 |
mutually_exclusive (Q92556)
|
bioplex3_WMM WMM_only | |
| DOCK2 | DOCK1 | 0.869 | 0.188 | bioplex3_WMM WMM_only | |
| DOCK2 | ELMO2 | 0.768 | 0.062 | bioplex3_WMM WMM_only | |
| RAC2 | DOCK3 | 0.587 | 0.256 | bioplex3_WMM WMM_only | |
| ELMO1 | AHI1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ELMO2 | AHI1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RAC2 | DOCK2 | 0.133 | 0.262 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| ELMO1 | DOCK2 | 0.055 | 0.328 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| ELMO3 | AHI1 | 0.051 | bioplex3_WMM WMM_only | ||
| DOCK1 | AHI1 | 0.014 | youn_WMM WMM_only | ||
| DOCK4 | AHI1 | 0.006 | youn_WMM WMM_only |
Related Complexes