hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10772.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMG6 | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | 5 | UniProt NCBI |
| ATG101 | Autophagy-related protein 101 | 5 | UniProt NCBI |
| ULK2 | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | 5 | UniProt NCBI |
| ULK1 | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | 5 | UniProt NCBI |
| FAM221B | Protein FAM221B | 5 | UniProt NCBI |
| RB1CC1 | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | 5 | UniProt NCBI |
| ATG13 | Autophagy-related protein 13 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7091 | 1.92263483365e-12 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | FIP200-ULK1-ATG13-ATG101 complex |
| CORUM:6232 | 1.92263483365e-12 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | ULK1-ATG13-RB1CC1-ATG101 complex |
| CORUM:7065 | 6.72590627404e-11 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | WDR41-(C9orf72-SMCR8)-(FIP200-ULK1-ATG13-ATG101) complex |
| WP:WP5412 | 1.66729991706e-09 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | 8q11 23 RB1CC1 copy number variation |
| WP:WP4863 | 5.09349097308e-09 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | Host pathogen interaction of human coronaviruses autophagy |
| CORUM:6230 | 7.02338504734e-09 | 0.428571428571 | RB1CC1 ULK2 ATG13 | ULK2-ATG13-RB1CC1 complex |
| CORUM:6229 | 7.02338504734e-09 | 0.428571428571 | ULK1 ATG13 RB1CC1 | ULK1-ATG13-RB1CC1 complex |
| WP:WP4923 | 3.40254542507e-08 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Autophagy |
| GO:0000407 | 3.79614366876e-08 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | phagophore assembly site |
| KEGG:05017 | 4.56608189276e-08 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Spinocerebellar ataxia |
| GO:1990316 | 1.1594342202e-07 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Atg1/ULK1 kinase complex |
| KEGG:04140 | 1.39999416482e-07 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Autophagy - animal |
| WP:WP4577 | 1.5157281404e-07 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:0034727 | 1.93207287326e-07 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | piecemeal microautophagy of the nucleus |
| GO:1903059 | 1.93207287326e-07 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | regulation of protein lipidation |
| GO:0050746 | 6.57500588447e-07 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | regulation of lipoprotein metabolic process |
| GO:0016237 | 1.25481586619e-06 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | microautophagy |
| GO:0034045 | 1.25481586619e-06 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | phagophore assembly site membrane |
| WP:WP5205 | 1.3444660011e-06 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Clock controlled autophagy in bone metabolism |
| KEGG:04211 | 1.57924080729e-06 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Longevity regulating pathway |
| WP:WP5124 | 1.75154609698e-06 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Alzheimer 39 s disease |
| WP:WP2059 | 1.75154609698e-06 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Alzheimer 39 s disease and miRNA effects |
| GO:0044804 | 2.1871649556e-06 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | nucleophagy |
| KEGG:05016 | 2.24688772699e-06 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Huntington disease |
| KEGG:05014 | 5.48831839723e-06 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 6.98132804135e-06 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Alzheimer disease |
| GO:0000045 | 1.14384163582e-05 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | autophagosome assembly |
| GO:1905037 | 1.40824256227e-05 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | autophagosome organization |
| KEGG:04136 | 1.41786055432e-05 | 0.428571428571 | ATG101 ULK2 ATG13 | Autophagy - other |
| KEGG:05022 | 1.86253065411e-05 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | Pathways of neurodegeneration - multiple diseases |
| WP:WP3844 | 2.46070726638e-05 | 0.428571428571 | ULK1 ATG13 RB1CC1 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| WP:WP5381 | 2.500856884e-05 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-1632852 | 3.5016953291e-05 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Macroautophagy |
| GO:0010508 | 4.37430645327e-05 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | positive regulation of autophagy |
| REAC:R-HSA-9612973 | 5.50598372696e-05 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | Autophagy |
| CORUM:6816 | 0.000123103089524 | 0.285714285714 | ULK1 ATG13 | ULK1-ATG13-ATG14-PIK3C3 complex |
| GO:0007033 | 0.000283744299021 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | vacuole organization |
| WP:WP5420 | 0.000302107483407 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0006497 | 0.000617288463902 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | protein lipidation |
| GO:0042158 | 0.000657005257405 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | lipoprotein biosynthetic process |
| WP:WP5087 | 0.00123233352092 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | Pleural mesothelioma |
| GO:0000422 | 0.00136674157899 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | autophagy of mitochondrion |
| GO:0042157 | 0.00143843813729 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | lipoprotein metabolic process |
| GO:0031331 | 0.00211304872099 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | positive regulation of cellular catabolic process |
| GO:0016236 | 0.00223322150095 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | macroautophagy |
| GO:0061709 | 0.00228108846854 | 0.428571428571 | ULK1 ULK2 RB1CC1 | reticulophagy |
| GO:0010506 | 0.003180883993 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | regulation of autophagy |
| WP:WP2509 | 0.00409583359214 | 0.285714285714 | ULK1 ULK2 | Nanoparticle triggered autophagic cell death |
| GO:1902554 | 0.00903437394907 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | serine/threonine protein kinase complex |
| WP:WP1471 | 0.00991981492579 | 0.285714285714 | ULK1 ULK2 | Target of rapamycin signaling |
| GO:1902911 | 0.0150328542879 | 0.571428571429 | ATG101 RB1CC1 ATG13 ULK1 | protein kinase complex |
| GO:1903008 | 0.0154598067374 | 0.571428571429 | ULK1 ULK2 ATG13 RB1CC1 | organelle disassembly |
| GO:0009896 | 0.0196256550357 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | positive regulation of catabolic process |
| GO:0006914 | 0.0261282499937 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | autophagy |
| GO:0061919 | 0.0261282499937 | 0.714285714286 | ATG101 RB1CC1 ULK2 ATG13 ULK1 | process utilizing autophagic mechanism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG101 | ATG13 | 0.998 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | RB1CC1 | 0.998 | 0.212 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | ULK1 | 0.996 | 0.104482142857 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RB1CC1 | FAM221B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMG6 | FAM221B | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG101 | FAM221B | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG13 | FAM221B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RB1CC1 | ATG13 | 0.982 | 0.222 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | FAM221B | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG101 | ULK2 | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ULK1 | ATG13 | 0.871 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | RB1CC1 | 0.868 | 0.312 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK2 | ATG13 | 0.415 | bioplex3_WMM WMM_only | |
| ULK2 | ULK1 | 0.415 | bioplex3_WMM WMM_only | |
| ULK2 | RB1CC1 | 0.25 | bioplex3_WMM WMM_only | |
| SMG6 | RB1CC1 | 0.187 | 0.198 | bioplex_WMM bioplex3_WMM WMM_only |
| SMG6 | ULK1 | 0.164 | 0.278 | bioplex_WMM bioplex3_WMM WMM_only |
| SMG6 | ATG101 | 0.164 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only |
| SMG6 | ATG13 | 0.143 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes