hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10776.1
Complex Portal: CPX-24148
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC2A8 | Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1) | 5 | UniProt NCBI |
| TRAK1 | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | 5 | UniProt NCBI |
| SAMM50 | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | 5 | UniProt NCBI |
| IMMT | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | 5 | UniProt NCBI |
| MTX3 | Metaxin-3 | 4 | UniProt NCBI |
| MTX2 | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | 5 | UniProt NCBI |
| APOOL | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | 5 | UniProt NCBI |
| CRACR2B | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | 5 | UniProt NCBI |
| CARD19 | Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD) | 5 | UniProt NCBI |
| TMEM263 | Transmembrane protein 263 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6249 | 1.69065897579e-09 | 0.4 | MTX2 APOOL SAMM50 IMMT | MIB complex |
| GO:0001401 | 1.79354716891e-09 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | SAM complex |
| GO:0140275 | 1.79354716891e-09 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | MIB complex |
| GO:0005742 | 3.50299770166e-08 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial outer membrane translocase complex |
| GO:0098799 | 4.59637226279e-08 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | outer mitochondrial membrane protein complex |
| REAC:R-HSA-8949613 | 7.25322049724e-07 | 0.4 | MTX2 APOOL SAMM50 IMMT | Cristae formation |
| GO:0007007 | 1.47824592381e-06 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | inner mitochondrial membrane organization |
| REAC:R-HSA-1592230 | 5.5176603535e-05 | 0.4 | MTX2 APOOL SAMM50 IMMT | Mitochondrial biogenesis |
| GO:0007006 | 7.27476492791e-05 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial membrane organization |
| CORUM:6255 | 0.000460692494101 | 0.2 | APOOL IMMT | MICOS complex |
| GO:0098800 | 0.00116347530131 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | inner mitochondrial membrane protein complex |
| GO:0005741 | 0.00167178873394 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial outer membrane |
| KEGG:04137 | 0.00170732395933 | 0.3 | MTX2 SAMM50 MTX3 | Mitophagy - animal |
| GO:0031968 | 0.00271155417988 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | organelle outer membrane |
| HPA:0241103 | 0.00277191770745 | 0.6 | IMMT APOOL CRACR2B MTX2 TRAK1 SAMM50 | heart muscle; cardiomyocytes[High] |
| GO:0019867 | 0.00279050287078 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | outer membrane |
| GO:0007005 | 0.00318379965526 | 0.6 | IMMT APOOL MTX3 MTX2 TRAK1 SAMM50 | mitochondrion organization |
| REAC:R-HSA-1852241 | 0.00569008336058 | 0.4 | MTX2 APOOL SAMM50 IMMT | Organelle biogenesis and maintenance |
| GO:0042407 | 0.00642915610421 | 0.3 | APOOL SAMM50 IMMT | cristae formation |
| HPA:0360053 | 0.0153776251203 | 0.6 | IMMT CRACR2B MTX3 MTX2 TRAK1 SAMM50 | parathyroid gland; glandular cells[High] |
| GO:0098798 | 0.0316699453157 | 0.5 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial protein-containing complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SAMM50 | MTX2 | 1.0 | 0.958 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| IMMT | MTX2 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM | ||
| MTX2 | CARD19 | 1.0 | 0.27 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| TRAK1 | CARD19 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTX3 | MTX2 | 0.998 | 0.32 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| IMMT | CARD19 | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| SAMM50 | CARD19 | 0.998 | 0.26 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SAMM50 | IMMT | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| TRAK1 | SAMM50 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTX3 | CARD19 | 0.995 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TRAK1 | IMMT | 0.993 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTX3 | TMEM263 | 0.989 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SLC2A8 | TMEM263 | 0.986 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SAMM50 | MTX3 | 0.985 | 0.404 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| IMMT | MTX3 | 0.983 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| TRAK1 | MTX2 | 0.982 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| APOOL | CARD19 | 0.978 | 0.196 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MTX2 | TMEM263 | 0.977 | 0.026 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CRACR2B | CARD19 | 0.971 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MTX2 | SLC2A8 | 0.97 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SAMM50 | SLC2A8 | 0.97 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| IMMT | TMEM263 | 0.955 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | ||
| MTX3 | APOOL | 0.95 | 0.104 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IMMT | SLC2A8 | 0.948 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | ||
| SAMM50 | APOOL | 0.948 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MTX2 | APOOL | 0.948 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IMMT | APOOL | 0.94 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| SAMM50 | TMEM263 | 0.904 | 0.028 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only | |
| TRAK1 | MTX3 | 0.855 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| APOOL | SLC2A8 | 0.713 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MTX3 | SLC2A8 | 0.683 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TRAK1 | APOOL | 0.41 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| APOOL | TMEM263 | 0.161 | 0.01 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CARD19 | TMEM263 | 0.066 | 0.068 | hein_WMM bioplex3_WMM WMM_only | |
| CARD19 | SLC2A8 | 0.06 | bioplex3_WMM WMM_only | ||
| IMMT | CRACR2B | 0.033 | bioplex3_HEK293 bioplex () |
Related Complexes