hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10779.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLEKHN1 | Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein) | 5 | UniProt NCBI |
| KPTN | KICSTOR complex protein kaptin (Actin-associated protein 2E4) | 5 | UniProt NCBI |
| ELP2 | Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1) | 5 | UniProt NCBI |
| ELP3 | Elongator complex protein 3 (hELP3) (EC 2.3.1.-) (tRNA uridine(34) acetyltransferase) | 5 | UniProt NCBI |
| DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | 5 | UniProt NCBI |
| ELP1 | Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) | 5 | UniProt NCBI |
| DPH1 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1) | 5 | UniProt NCBI |
| FAM219B | Protein FAM219B | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2716 | 9.82248594942e-09 | 0.375 | ELP2 ELP3 ELP1 | Elongator core complex |
| CORUM:1380 | 3.92798604902e-08 | 0.375 | ELP2 ELP3 ELP1 | Elongator holo complex |
| CORUM:6332 | 1.962985025e-07 | 0.375 | ELP2 ELP3 ELP1 | Elongator complex (ELP1, ELP2, ELP3, ELP4, ELP5, ELP6) |
| GO:0033588 | 0.00010757157937 | 0.375 | ELP2 ELP3 ELP1 | elongator holoenzyme complex |
| HP:0030799 | 0.000714829774892 | 0.375 | KPTN DPH2 DPH1 | Scaphocephaly |
| REAC:R-HSA-5358493 | 0.00116989543065 | 0.25 | DPH2 DPH1 | Synthesis of diphthamide-EEF2 |
| GO:0002098 | 0.00364711882004 | 0.375 | ELP2 ELP3 ELP1 | tRNA wobble uridine modification |
| HP:0012712 | 0.00474009355523 | 0.25 | DPH2 DPH1 | Mild hearing impairment |
| GO:0002097 | 0.00610957850275 | 0.375 | ELP2 ELP3 ELP1 | tRNA wobble base modification |
| REAC:R-HSA-3214847 | 0.00775010993696 | 0.375 | ELP2 ELP3 ELP1 | HATs acetylate histones |
| GO:0090560 | 0.0131096201623 | 0.25 | DPH2 DPH1 | 2-(3-amino-3-carboxypropyl)histidine synthase activity |
| HP:0007291 | 0.0270195830756 | 0.25 | DPH2 DPH1 | Posterior fossa cyst |
| REAC:R-HSA-163841 | 0.0367988237757 | 0.25 | DPH2 DPH1 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| GO:0002926 | 0.0393180950424 | 0.25 | ELP3 ELP1 | tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation |
| HP:0004442 | 0.0427341718023 | 0.25 | DPH2 DPH1 | Sagittal craniosynostosis |
| HP:0001970 | 0.0472195728067 | 0.25 | DPH2 DPH1 | Tubulointerstitial nephritis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ELP2 | ELP3 | 1.0 | 0.576 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| ELP1 | ELP3 | 1.0 | 0.592 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| ELP2 | ELP1 | 0.999 | 0.608 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| ELP2 | FAM219B | 0.998 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELP1 | KPTN | 0.997 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DPH2 | FAM219B | 0.995 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELP3 | FAM219B | 0.993 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELP3 | KPTN | 0.992 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DPH2 | DPH1 | 0.99 | 0.382 | bioplex_WMM Guru bioplex3_WMM fraction |
| FAM219B | DPH1 | 0.99 | 0.082 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PLEKHN1 | ELP3 | 0.984 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ELP2 | KPTN | 0.98 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELP1 | FAM219B | 0.972 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELP3 | DPH1 | 0.885 | 0.216 | bioplex_WMM bioplex3_WMM WMM_only |
| ELP1 | PLEKHN1 | 0.806 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ELP2 | DPH2 | 0.722 | 0.184 | bioplex_WMM bioplex3_WMM WMM_only |
| ELP2 | DPH1 | 0.602 | 0.262 | bioplex_WMM bioplex3_WMM WMM_only |
| ELP1 | DPH1 | 0.464 | 0.33 | bioplex_WMM bioplex3_WMM WMM_only |
| ELP2 | PLEKHN1 | 0.392 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ELP3 | DPH2 | 0.244 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only |
| ELP1 | DPH2 | 0.208 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only |
| KPTN | DPH1 | 0.075 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes